JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS(英文缩写 J PHARMACOL EXP THER),ISSN 0022-3565,eISSN 1521-0103 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-21 至 2026-09-21，按本站收录文献的发表日期统计。
指标来源：jcr_cas_ifqb
期刊简介
暂无简介。
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 4.404 | Q2 |
| 2022 | 3.500 | Q2 |
| 2023 | 3.100 | Q2 |
| 2024 | 3.800 | Q2 |
| 2025 | 4.300 | Q2 |
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 最新收录文献
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2. Profiles of nonsteroidal anti-inflammatory drug-induced gastric antral ulcers: A comprehensive review of the preclinical data.
PMID:作者:日期:2026-08-29Nonsteroidal anti-inflammatory drugs (NSAIDs) frequently induce gastric ulcers in the prepyloric antrum in humans; however, the mechanisms underlying this antral specificity remain unclear. Moreover, although gastric antral ulcers (AUs) exhibit poor responsiveness to histamine H receptor antagonists…
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3. Calpeptin and protein kinase C inhibition suppress exosome-associated inflammatory signaling and epidermal dysregulation in a 3-dimensional psoriatic skin model.
PMID:作者:日期:2026-08-25Psoriasis is a chronic inflammatory skin disorder characterized by dysregulated cytokine signaling and keratinocyte hyperproliferation, in which extracellular vesicles, particularly exosomes, play key roles in mediating intercellular inflammatory communication. In this study, we evaluated the pharma…
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4. Shiheleucel, an allogeneic natural killer cell product expanded under chemically defined conditions, in combination with rituximab-based chemotherapy in relapsed/refractory diffuse large B-cell lymphoma: An exploratory clinical study.
PMID:作者:日期:2026-08-18Natural killer (NK) cell dysfunction contributes to tumor resistance, particularly in antibody-dependent cell-mediated cytotoxicity. This study evaluated a fully chemically defined system for expanding high-purity NK (hpNK) cells and their clinical application. In preclinical studies, hpNK demonstra…
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5. BE2012 a novel, REV-ERB antagonist that promotes regenerative myogenesis in vivo with substantially improved pharmacokinetics relative to SR8278.
PMID:作者:日期:2026-08-17Pharmacological inhibition of REV-ERBs has emerged as a potential therapeutic strategy for several diseases with unmet medical needs. Indeed, chronic treatment with SR8278, a synthetic REV-ERB antagonist, has mitigated pathology in various preclinical models of human musculoskeletal and neurological…
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6. Prior Toll-like receptor 3 stimulation abolishes the ability of a MAPK/ERK kinase inhibitor to increase lipopolysaccharide-induced nitric oxide production concomitant with tumor necrosis factor-α suppression.
PMID:作者:日期:2026-08-17Lipopolysaccharide (LPS) is an endotoxin that can trigger multiple types of acute organ failure by increasing the production of nitric oxide (NO), which is synthesized by inducible NO synthase (iNOS) in macrophages through increased production of tumor necrosis factor (TNF)-α, interferon gamma, and …
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7. {"_":"Δ-Tetrahydrocannabinol treatment impairs CD8 T cell differentiation into interferon gamma-competent CD45RO cells.","sup":["9","+","+"]}
PMID:作者:日期:2026-08-14Chronic human immunodeficiency virus (HIV) infection results in a persistent state of neuroinflammation, even with combined antiretroviral therapy. Neuroinflammation contributes to pathology termed HIV-associated neurocognitive disorder, which is exacerbated by interferon gamma (IFNγ)-producing CD8 …
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8. Mitochondrial proteomic signatures of postcardiac arrest brain injury reveal potential therapeutic targets.
PMID:作者:日期:2026-08-14Mitochondrial dysfunction is central to postcardiac arrest brain injury (PCABI); however, the underlying protein networks involved remain poorly defined. SRT1720, a silent information regulator 1 activator, exhibits potential mitochondrial protective effects, although its role and mechanisms in PCAB…
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9. {"_":"Impact of Δ-tetrahydrocannabinol and oxycodone coadministration on measures of antinociception, dependence, circadian activity, and reward in mice.","sup":["9"]}
PMID:作者:日期:2026-08-14Oxycodone is commonly prescribed for moderate-to-severe pain. While efficacious, long-term use can result in tolerance, physical dependence, and opioid use disorder. Cannabis and Δ-tetrahydrocannabinol (Δ-THC) have been reported to potentiate oxycodone-induced antinociception in animals and humans. …
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10. A novel drug sequestrant-based therapeutic candidate reverses methamphetamine-induced hyperthermia and hypermetabolism and abates multiorgan toxicity in rats.
PMID:作者:日期:2026-08-07Methamphetamine (meth) is a central nervous system stimulant associated with many fatalities. Meth can cause agitation and psychosis, hyperthermia, and multiple organ damage. Medical treatment of meth toxicity is challenged because of meth's prolonged clinical duration of action and the lack of targ…