EUROPEAN POLYMER JOURNAL欧洲聚合物杂志
EUROPEAN POLYMER JOURNAL(英文缩写 EUR POLYM J),ISSN 0014-3057,eISSN 1873-1945,中文译名:欧洲聚合物杂志 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 5.546 | Q1 |
| 2022 | 6.000 | Q1 |
| 2023 | 5.800 | Q1 |
| 2024 | 6.300 | Q1 |
| 2025 | 6.800 | Q1 |
EUROPEAN POLYMER JOURNAL 最新收录文献
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1. Siloxane-tethered poly(2-ethyl-2-oxazoline) as surface modifying additives for anti-fouling silicones.
1. 硅氧烷系聚(2-乙基-2-噁唑啉)作为防污硅酮的表面改性添加剂PMID:日期:2026-03-11While silicones are broadly utilized for medical devices, their hydrophobic nature renders them highly prone to biofouling, leading to reduced safety and efficacy. We have previously demonstrated that biofouling is reduced for silicones combined with amphiphilic surface modifying additives (SMAs) comprised of a poly(ethylene glycol) (PEG) segment and a siloxane tether (PEG-silane). However, there is a rising concern regarding the potential immunogenicity of PEG. Herein, SMAs were created wherein poly(2-ethyl-2-oxazoline) (PEtOx) was substituted for PEG. PEtOx-silane SMAs (H-Si-DMS --PEtOx; = 13 and 30) were synthesized, and each incorporated into unfilled (i.e., silica-free) silicones: dimethyl silicone [MED-6019; 0% Ph], dimethyl diphenyl silicone [MED-6010; 5.8% Ph], and dimethyl diphenyl silicone [MED-6020; 8.5% Ph] at increasing concentrations (5 - 25 μmol g). Analogous PEG-silane SMAs (H-Si-DMS --PEG; = 13 and 30) were likewise used to modify the silicones. The chemical crosslinking and subsequent retention of SMAs in modified silicones was confirmed. The resulting properties imparted by a particular SMA were impacted by the phenyl content of the silicone. However, PEtOx-based SMAs generally produced a greater plasticizing effect than PEG-based SMAs. Fouling against fibrinogen, a fungus, and four bacteria was assessed for silicones modified with each SMA (25 μmol g). In general, silicones modified with POx-based SMAs demonstrated greater anti-fouling behavior versus unmodified silicones. DMS-POx often achieved similar anti-fouling efficacy versus PEG-based SMAs. These results point to the potential of amphiphilic POx-based SMAs to produce anti-fouling silicones.
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2. {"_":"Mechanistic insights into the calcium-mediated gelation of poly(4--butylstyrene--maleic acid)--poly(-acryloylmorpholine) double hydrophilic block copolymers.","i":["tert","alt","block","N"]}
2. 钙介导的聚(4-叔丁基苯乙烯-交替-马来酸)-聚(N-丙烯酰吗啉)双亲水嵌段共聚物凝胶化的机理研究PMID:日期:2026-02Stimuli responsive double hydrophilic block copolymers (DHBCs) are ubiquitous in water-based applications, such as drug/gene delivery, nanoreactor and sensor development, photocatalysis, 3D inkjet printing, etc. DHBC-based gels, cross-linked with calcium ions, are particularly valuable for the development of biomedically relevant materials (such as wound dressings or injectable formulations), due to the benignity of Ca in biological systems. Therefore, gels formed the calcium-mediated crosslinking of poly(4--butylstyrene--maleic acid)--poly(-acryloylmorpholine) (PBuSMA--PNAM), which in itself constitutes polymers with established biomedical relevance, are promising candidates for the development of the aforementioned biomedical materials. To this end, PBuSMA--PNAM diblock copolymers were synthesized with different block ratios (1:1, 1:2 and 2:1) and treated with Ca, whereby the concentration of the two constituents, the pH or the block copolymer architecture was varied, in order to tune the mechanical properties of the PBuSMA--PNAM/Ca gels. PBuSMA--PNAM/Ca with the lowest PBuSMA composition (1:2 block ratio) could not form gels and rather formed micelles, whereas PBuSMA--PNAM/Ca with the highest PBuSMA composition (2:1 block ratio) exhibited enhanced mechanical properties compared to the 1:1 block ratio. The overall amphiphilic balance of the PBuSMA--PNAM/Ca complexes was therefore proven vital for the design and formation of gels with desirable mechanical properties. PBuSMA--PNAM/Ca gels exhibited shear thinning when subjected to high shear conditions and demonstrated some self-healing properties, suggesting these materials have value in the formulation of injectable gels.
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3. {"_":"Sulfonated polystyrenes: pH and Mg-insensitive amphiphilic copolymers for detergent-free membrane protein isolation.","sup":["2+"]}
PMID:日期:2023-09-09Amphiphilic polymers are increasingly applied in the detergent-free isolation and functional studies of membrane proteins. However, the carboxylate group present in the structure of many popular variants, such as styrene-maleic acid (SMA) copolymers, brings limitations in terms of polymer sensitivity to precipitation at acidic pH or in the presence of divalent metal cations. Herein, we addressed this problem by replacing carboxylate with the more acidic sulfonate groups. To this end, we synthesized a library of amphiphilic poly[styrene--(sodium 4-styrene sulfonate)] copolymers (termed SSS), differing in their molecular weight and overall polarity. Using model cell membranes (Jurkat), we identified two copolymer compositions (SSS-L30 and SSS-L36) that solubilized membranes to an extent similar to SMA. Interestingly, the density gradient ultracentrifugation/SDS-PAGE/Western blotting analysis of cell lysates revealed a distribution of studied membrane proteins in the gradient fractions that was different than for SMA-solubilized membranes. Importantly, unlike SMA, the SSS copolymers remained soluble at low pH and in the presence of Mg ions. Additionally, the solubilization of DMPC liposomes by the lead materials was studied by turbidimetry, DLS, SEC, and high-resolution NMR, revealing, for SSS-L36, the formation of stable particles (nanodiscs), facilitated by the direct hydrophobic interaction of the copolymer phenyls with lipid acyl chains.
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4. Polymer modification of SARS-CoV-2 spike protein impacts its ability to bind key receptor.
4. SARS-CoV-2刺突蛋白的聚合物修饰影响其与关键受体结合的能力PMID:日期:2022-12-14The global spread of SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) has caused the loss of many human lives and severe economic losses. SARS-CoV-2 mediates its infection in humans via the spike glycoprotein. The receptor binding domain of the SARS-CoV-2 spike protein binds to its cognate receptor, angiotensin converting enzyme-2 (ACE2) to initiate viral entry. In this study, we examine how polymer modification of the spike protein receptor binding domain impacts binding to ACE2. The horseradish peroxidase conjugated receptor binding domain was modified with a range of polymers including hydrophilic -dimethylacrylamide, hydrophobic -isopropylacrylamide, cationic 3-(-dimethylamino)propylacrylamide, and anionic 2-acrylamido-2-methylpropane sulfonic acid polymers. The effect of polymer chain length was observed using -dimethylacrylamide polymers with degrees of polymerization of 5, 10 and 25. Polymer conjugation of the receptor binding domain significantly reduced the interaction with ACE2 protein, as determined by an enzyme-linked immunosorbent assay. Stability analysis showed that these conjugates remained highly stable even after seven days incubation at physiological temperature. Hence, this study provides a detailed view of the effect specific type of modification using a library of polymers with different functionalities in interrupting RBD-ACE2 interaction.
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5. Controlling tosylation versus chlorination during end group modification of PCL.
5. 在PCL端基修饰过程中控制甲苯磺酰化与氯化的比较PMID:日期:2022-11Synthetic biodegradable materials are commonly used to create constructs for medical devices and tissue engineered constructs. However, many of the homopolymers used in FDA approved devices such as poly (ε-caprolactone) (PCL), poly(lactic acid), or poly(carbonates) lack biogically relevant functional groups to steer biological responses in a controlled fashion. Commonly, an interconversion of the end groups is required to insert addressable moieties for the attachment of biologically active groups. In this study, the activation of the hydroxyl groups of a low molecular weight PCL-diol to the corresponding p-toluene sulfonate ester using p-toluenesulfonyl chloride was performed in both dichloromethane (DCM) and dimethylformamide (DMF). To our initial surprise, we only yielded the chlorinated product in DMF, while in DCM the tosylate ester was obtained. In a small series of reactions, we studied the solvent dependent switchability between tosylation and chlorination on PCL. We concluded that in polar aprotic solvents (DMF and dimethylsulfoxide), we rapidly and efficiently converted the hydroxyl into the chloride group, whereas in inert solvents (DCM and chloroform) we yielded the tosylated product. The data suggested that solvation effects of the polar aprotic solvents led to a S2 reaction of the tosyl group by the chloride. Furthermore, we utilized a polyethylene glycol (PEG) polymer to show translatability of the chlorination reaction to other (biomedical) polymers. This work highlights a new reaction pathway during the tosylation of a polymer end group, and presents a new useful strategy to insert clickable groups on synthetic polymers that are only soluble in polar aprotic solvents.
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6. Molecular dynamics simulations of quinine encapsulation into biodegradable nanoparticles: A possible new strategy against Sars-CoV-2.
6. 奎宁封装入可生物降解纳米颗粒的分子动力学模拟：一种可能对抗Sars-CoV-2的新策略PMID:日期:2021-08-04A new coronavirus disease, SARS-CoV-2, has spread into a global pandemic in December 2019. Since no specific therapeutic drugs for treating COVID-19 have been approved by FDA, recent studies suggest that the known antimalarial quinine and its derivatives (chloroquine and hydroxychloroquine) inhibit receptor binding of the viral particles and inhibits the strong "cytokine storm", which is the main cause of death among infected patients. In particular, the natural alkaloid quinine has shown to possess a better safety profile and greater tolerability compared to its derivatives. Dosage optimization of quinine is still necessary as the currently available dosage forms have controversial pharmacokinetics and safety profiles. Therefore, repurposing quinine dosage forms to improve its pharmacokinetics and safety profile may be necessary to support its use against SARS-CoV-2. In this context, biodegradable/biocompatible polymeric nanoparticles may provide a safe site-specific and controlled quinine delivery, reducing the frequency of drug administration and the dose. In this study, a full atomistic molecular dynamics simulation approach has been used to investigate the use of poly-(glycolic acid) and poly-(lactic acid) and their copolymer poly-(lactic-co-glycolic acid) as potential delivery systems for lipophilic quinine to get insights into the mechanism of quinine encapsulation and release at the atomic/molecular level.
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7. Ice recrystallisation inhibiting polymers prevent irreversible protein aggregation during solvent-free cryopreservation as additives and as covalent polymer-protein conjugates.
PMID:日期:2020-11-05Protein storage and transport is essential to deliver therapies (biologics), enzymes for biotechnological applications, and underpins fundamental structural and molecular biology. To enable proteins to be stored and transported it is often essential to freeze them, requiring cryoprotectants such as glycerol or trehalose. Here we explore the mechanisms by which poly(vinyl alcohol), PVA, a potent ice recrystallisation inhibitor protects proteins during freeze/thaw to enable solvent-free cryopreservation with a focus on comparing mixing, verses polymer-protein conjugation. A panel of poly(vinyl alcohol)s are investigated including commercial, well-defined (from RAFT), and PVA-protein conjugates, to map out PVA's efficacy. Enzymatic activity recovery of lactate dehydrogenase was found to correlate with post-thaw aggregation state (less aggregated protein had greater activity), which was modulated by PVA's ice recrystallisation inhibition activity. This macromolecular cryoprotectant matched the performance of glycerol, but at lower additive concentrations (as low as 1 mg.mL). It was also demonstrated that storage at -20 °C, rather than -80 °C was possible using PVA as a cryoprotectant, which is not possible with glycerol storage. A second protein, green-fluorescent protein (GFP), was used to enable screening of molecular weight effects and to obtain PVA-GFP bioconjugates. It was observed that covalent attachment of RAFT-derived PVA showed superior cryoprotectant activity compared to simple mixing of the polymer and protein. These results show that PVA is a real alternative to solvent-based protein storage with potential in biotechnology, food and therapeutics. PVA is already approved for many biomedical applications, is low cost and available on a large scale, making it an ideal cryoprotectant formulation enhancer.
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8. {"_":"Tuning small molecule release from polymer micelles: Varying HS release through cross linking in the micelle core.","sub":["2"]}
PMID:日期:2020-10-06Polymer micelles, used extensively as vehicles in the delivery of active pharmaceutical ingredients, represent a versatile polymer architecture in drug delivery systems. We hypothesized that degree of crosslinking in the hydrophobic core of amphiphilic block copolymer micelles could be used to tune the rate of release of the biological signaling gas (gasotransmitter) hydrogen sulfide (HS), a potential therapeutic. To test this hypothesis, we first synthesized amphiphilic block copolymers of the structure PEG--P(FBEA) (PEG = poly(ethylene glycol), FBEA = 2-(4-formylbenzoyloxy)ethyl acrylate). Using a modified arm-first approach, we then varied the crosslinking percentage in the core-forming block addition of a alkanediyl bis(hydroxylamine) crosslinking agent. We followed incorporation of the crosslinker by H NMR spectroscopy, monitoring the appearance of the oxime signal resulting from reaction of pendant aryl aldehydes on the block copolymer with hydroxylamines on the crosslinker, which revealed crosslinking percentages of 5, 10, and 15%. We then installed HS-releasing -aroylthiooxime (SATO) groups on the crosslinked polymers, yielding micelles with SATO units in their hydrophobic cores after self-assembly in water. HS release studies in water, using cysteine (Cys) as a trigger to induce HS release from the SATO groups in the micelle core, revealed increasing half-lives of HS release, from 117 ± 6 min to 210 ± 30 min, with increasing crosslinking density in the micelle core. This result was consistent with our hypothesis, and we speculate that core crosslinking limits the rate of Cys diffusion into the micelle core, decreasing the release rate. This method for tuning the release of covalently linked small molecules through modulation of micelle core crosslinking density may extend beyond HS to other drug delivery systems where precise control of release rate is needed.
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9. Influence of the organic matrix composition on the polymerization behavior and bulk properties of resin composites containing thiourethane-functionalized fillers.
9. 有机基质组成对含硫氨酯功能化填料的树脂复合材料的聚合行为及本体性能的影响PMID:日期:2020-04-06The incorporation of thiourethane-based oligomeric additives into resin composite formulations leads to improvement in mechanical properties and reduction in polymerization stress, but may increase viscosity. The objective of this study was to functionalize filler particle surfaces with thiourethane silane molecules and determine the impact of the inorganic filler loading and surface treatment on the behavior of experimental resin composites with systematically-varied organic matrices. Thiourethane oligomer was synthesized , and grafted to the surface of 0.7um barium glass. BisGMA and TEGDMA (BT) were combined (at 30:70, 50:50 or 70:30 wt%) to 50 or 75 wt% of methacrylate (MA-Sil - control) or thiourethane-silanized (TU-Sil) particles. Composites were made polymerizable by the addition of 0.2 wt% BAPO and 0.05 wt% BHT was added as inhibitor. A mercury arc lamp (320-500 nm) at 800 mW/cm was used for all curing procedures. Kinetics of polymerization was assessed by near-IR spectroscopy in real time. Polymerization stress was determined with a cantilever system in real time (Bioman). Flexural modulus and strength were determined in 3-point bending (25x2x2 mm). Water sorption and solubility and film thickness were tested according to ISO 4049. Polymeric network characteristics were analyzed by dynamic mechanical analysis (DMA). Data was analyzed with two-way ANOVA/Tukey's test (95%). Viscosity increased with the increase in BisGMA and/or filler amounts. Overall, TU-Sil containing composites showed delayed vitrification and higher final DC. Filler concentration did not affect DC neither flexural strength. DC decreased with increasing BisGMA content. Polymerization stress reduced and flexural modulus increased for higher filler content, especially for formulations containing TU-Sil particles. The water stability was positively affected by the increase in amount of BisGMA and inorganic filler particles. In terms of polymeric network, the addition of TU-Sil particles increased the T and decreased the E' and cross-link density. With the exception of flexural modulus, all tested properties were significantly impacted by the matrix viscosity and/or the addition of TU-Sil filler particles. In general, the use of thiourethane oligomers as a silane coupling agent was able to reinforce the materials and reduce the polymerization stress without negatively affecting the viscosity of the system.
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10. Electrosprayed poly(lactic-co-glycolic acid) particles as a promising drug delivery system for the novel JNK inhibitor IQ-1.
10. 电喷雾聚乳酸-羟基乙酸共聚物颗粒作为一种有前景的药物递送系统，用于新型JNK抑制剂IQ-1PMID:日期:2020-03-04Mitogen-activated protein kinases (MAPKs), including c-Jun N-terminal kinase (JNK), play important role in the regulation of pro-inflammatory cytokine secretion and signaling cascades. Therefore, JNKs are key targets for the treatment of cytokine/JNK-driven diseases. Herein, we developed electrospray poly(lactic-co-glycolic acid) (PLGA) microparticles doped with novel JNK inhibitor 11-indeno[1,2-]quinoxalin-11-one oxime (IQ-1). Optimized electrospray parameters allowed us to produce IQ-1-doped microparticles with round shape, smooth and non-porous surface, and mean diameter of 0.9-1.3 μm. We have shown that IQ-1 was well integrated into the polymer matrix and had a prolonged release in two steps via non-Fickian release. The fabricated particles doped with IQ-1 exhibited anti-inflammatory effects, as indicated by inhibited neutrophil activation and cytokine secretion by human monocytic MonoMac-6 cells. Overall, our study demonstrates that PLGA microparticles doped with a novel JNK inhibitor (IQ-1) could be a promising delivery system for treatment of JNK-mediated diseases.