COORDINATION CHEMISTRY REVIEWS配位化学评论
COORDINATION CHEMISTRY REVIEWS(英文缩写 COORDIN CHEM REV),ISSN 0010-8545,eISSN 1873-3840,中文译名:配位化学评论 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 24.833 | Q1 |
| 2022 | 20.600 | Q1 |
| 2023 | 20.300 | Q1 |
| 2024 | 23.500 | Q1 |
| 2025 | 25.600 | Q1 |
COORDINATION CHEMISTRY REVIEWS 最新收录文献
-
1. Bimetallic Chemistry by Design: Approaches to the Development of Multifunctional Ligands.
1. 设计双金属化学：多功能配体开发的方法PMID:日期:2026-04-01Bimetallic complexes enable cooperative function that is inaccessible at mononuclear sites, yet realizing such behavior in a predictable manner requires precise control over metal identity, metal/metal separation and bridging ligand environments. This review surveys synthetic strategies for constructing bimetallic architectures and highlights how these concepts inform the rational design of multifunctional ligand platforms. We focus on the development of a tripodal ligand with phosphinic amido groups [poat] which enables the site-directed assembly of heterobimetallic cores. This framework provides access to FeFe, FeMn and CoFe complexes spanning multiple oxidation and protonation states, allowing systematic interrogation of proton-coupled electron transfer, redox thermodynamics, and magnetic exchange. Comparative studies reveal how metal substitution modulates oxidizing power, PCET reactivity, and spin-state behavior, offering molecular-level insight into cooperative principles that underlie both metalloenzyme function and functional bimetallic materials.
-
2. Navigating the Copper Chelation Highway: Tuning Copper for Coordination Chemistry for Tumor Control.
PMID:日期:2026-03-17The diverse chemical properties of copper (Cu) make it an attractive target in oncology. Cu plays central roles in angiogenesis, metastasis, redox regulation, and the activation of metalloenzymes that sustain tumor proliferation, making its homeostasis critical for cancer growth. Inspired by the clinical success of chelation therapy for heavy-metal poisoning and iron overload, metal-binding ligands are now either repurposed or newly designed and then structurally finetuned to modulate tumor copper levels. Diverse Cu-modulating strategies have emerged to disrupt Cu-dependent biochemical pathways and control tumor progression. These approaches can be grouped into two main categories: (1) Cuand Cuchelators that directly induce copper-dependent cytotoxicity, and (2) Cuionophores that facilitate intracellular copper transport and reductive release of Cu to selectively target specific protein partners. Rather than providing an exhaustive catalog, this work highlights how modern ligand design can manipulate Cu-protein interactions to inhibit tumor growth. Additionally, select compounds containing Cu radioisotopes are assessed for their potential use in cancer diagnostics, therapy, and theragnostics by exploiting the radiometal's favorable decay characteristics and balancing crucial chelator requirements to suppress the metal's redox activity and ligand exchange lability amongst other desired properties and appending cell receptor recognizing structural motifs for optimal cell delivery. By combining structure-function and structure activity relationship studies with imaging-guided and combination therapies, this work collectively aims to examine the feasibility of Cu implementation in the next-generation therapeutics and diagnostics/theragnostics to precisely modulate tumor growth while improving clinical outcomes.
-
3. N-Heterocyclic Carbene (NHC) Catalysis in Enzymatic Organic Synthesis.
PMID:日期:2025-11-03该文献暂无摘要。
-
4. {"_":"The Chemistry of Dinuclear Silver -Heterocyclic Carbene Complexes.","i":["N"]}
4. {"_":"双核银-杂环卡宾配合物的化学。","i":["N"]}PMID:日期:2025-07-16Dinuclear silver -heterocyclic carbene (Ag-NHC) complexes are readily accessible either by reacting imidazolium salts (e.g., Cl, Br, PF, BPh) with AgO or by the direct formation of the carbene from 1,3-disubstituted imidazol-2-ylidenes with a suitable base (e.g., KHMDS) followed by addition of silver salts (e.g., AgPF). Many Ag-NHC complexes have shown considerable potential across various fields due to their versatile properties. Notably, the lability of silver-carbene bonds enables efficient ligand transfer to other transition metals, thereby enhancing catalytic, photophysical, antimicrobial, and anticancer activities -key topics discussed in this review. Complexes with square geometries are particularly effective as chemosensors, offering low detection limits, high sensitivity, and selectivity. In antimicrobial and anticancer research, complexes with lipophilic side chains, benzimidazole groups, and silver -silver interactions show encouraging results, in some cases surpassing standard drugs. Despite these advances, their catalytic potential remains underexplored, with current catalysts showing performance similar to mononuclear analogs. Future studies should focus on designing catalysts with cooperating silver centers and incorporating novel functionalities, such as halogenated imidazoles, to improve both biological activity and catalytic efficiency.
-
5. {"_":"The Chemistry of Polynuclear Silver -Heterocyclic Carbene Complexes.","i":["N"]}
5. {"_":"多核银-杂环卡宾配合物的化学。","i":["N"]}PMID:日期:2025-06-20Polynuclear (tri-, tetra-, penta-, hexa-, polymeric-) silver -heterocyclic carbene (Ag-NHC) complexes can be synthesized by reacting imidazolium salts (e.g., Cl, Br, PF) with AgO, followed by anionic exchanges in some cases. The first polynuclear (tetra-) Ag-NHC complex was reported in 2002. Since then, these complexes have been explored in the literature for a variety of applications, including transmetallation, sensing, antimicrobial agents, and anticancer treatments, owing to their versatile properties. The labile silver-carbene bonds facilitate efficient ligand exchange with other transition metals such as Au, Cu, and Pd providing an efficient route to a variety of transition metal-NHC complexes with diverse applications. Tetranuclear Ag-NHC complexes that exhibit substantial fluorescence intensity have been used as sensors to detect persistent pollutants like 2,6-dichloronitroaniline with high sensitivity. Additionally, some trinuclear Ag-NHC complexes have demonstrated better antiproliferative activity than known chemotherapeutic drugs like 5-fluorouracil and cisplatin, highlighting the potential of these complexes as more stable and selective therapeutic agents. Overall, this review underscores the versatility of polynuclear Ag-NHC complexes across diverse fields, while emphasizing the importance of structural modifications to optimize their efficacy and minimize toxicity.
-
6. Coordination Chemistry of Emerging Meitner-Auger Electron-Emitting Radiometals for Targeted Radionuclide Therapy.
6. 新兴的用于靶向放射性核素治疗的迈特纳-俄歇电子发射放射性金属的配位化学PMID:日期:2025-06-11Targeted radionuclide therapy (TRT) selectively delivers radionuclides to cancer cells, leveraging their radioactive emissions to treat primary and metastatic malignancies. Substantial fundamental research in this area has enabled the clinical development of a growing library of radiopharmaceuticals for this application, several of which have become blockbuster cancer drugs approved by the U.S. Food and Drug Administration. To date, these therapeutics have focused on radiometals emitting long-range β particles and shorter-ranged α particles. More recently, efforts to use a different type of cytotoxic radiation, Meitner-Auger electrons (MAEs), have been undertaken. MAEs are of interest for TRT because they travel very short distances-on the order of nanometers-that enable the possibility of single-cell and subcellular delivery of cytotoxic radiation. This high spatial precision is valuable for the treatment of diffuse malignancies such as lymphoma and leukemia, as well as for inducing unique cell death pathways with efficacy against conventional radiation resistance. As a number of emerging MAE-emitting radiometals are identified and produced, there is a need to develop suitable chelators that can form stable complexes with them so that they can be applied in targeted constructs. This review summarizes the coordination chemistry of emerging MAE-emitting radiometals, which span different regions of the Periodic Table, including the transition metals, main group elements, and lanthanides. In addition, approaches for their production and purification are also described. The major emphasis of this manuscript provides a summary of different chelators and chelation approaches for these novel MAE-emitting radiometals. This comprehensive summary of the coordination chemistry of these radiometals provides a guide for researchers in this area and emphasizes the chelator-design challenges that need to be overcome for their eventual clinical use.
-
7. Application of smart responsive nanomaterials in the theranostics of gastrointestinal malignancies: Current status and future perspectives.
7. 智能响应纳米材料在胃肠道恶性肿瘤诊断中的应用：现状和未来前景PMID:日期:2025-03-29Gastrointestinal (GI) malignancies remain to be one of the most prevalent malignancies that are often characterized by a dismal prognosis. Nanoplatforms present a groundbreaking avenue for enhancing targeting strategies and multifunctionality in cancer treatment. The emergence of nanotechnology, particularly the innovation of smart responsive nanomaterials, has revolutionized cancer diagnosis and therapy. This review begins by exploring the design principles of smart responsive nanomaterials, focusing on the various exogenous and endogenous stimuli that drive their functionality. Furthermore, we provide a comprehensive summary of the applications of smart responsive nanomaterials in the treatment of GI malignancies over the past five years. Our aim is to contribute to the growing body of knowledge on smart responsive nanomaterials in GI malignancies, spark innovative ideas, and encourage further advancements in this field. Finally, we discuss the prospects and challenges associated with the use of smart responsive nanomaterials in GI malignancies.
-
8. Harnessing the power of nanoagents in acute kidney injury: A versatile platform for imaging and treatment.
8. 在急性肾损伤中利用纳米药物的力量：一个用于成像和治疗的多功能平台PMID:日期:2025-02-27Acute kidney injury (AKI), a severe complication marked by a sudden decline in renal function, is a significant public health concern with high morbidity and mortality rates. The early diagnosis and effective treatment of AKI remain challenging due to the complex etiology and pathophysiology of the disease. Nanoagents have emerged as a promising strategy for improving AKI management by enabling early detection, monitoring disease progression and enhancing treatment efficacy. This review provides a comprehensive overview of the recent advances in nanoagent-based approaches for AKI imaging and treatment. We first discuss the pathophysiological characteristics of AKI and their influence on nanoparticle targeting, accumulation, and clearance in diseased renal tissues. Next, we present a variety of nanoagent-based imaging techniques for monitoring kidney function and diagnosing AKI. We also outline the therapeutic principles of AKI and summarize the broad array of nanotherapeutic agents developed for AKI treatment. Finally, the review discusses the challenges of bringing nanoagent research into clinical use and explores future directions, emphasizing key opportunities to drive progress in this field.
-
9. Coupled Binuclear Copper Sites in Biology: An Experimentally-Calibrated Computational Perspective.
9. 生物学中的偶联双核铜位点：一种经实验校准的计算视角PMID:日期:2024-11-23The broad class of O-activating coupled-binuclear copper (CBC) metalloenzymes contain a unique [CuO] catalytic core. This core is responsible for catalyzing challenging biochemical transformations, particularly the regioselective monooxygenations/oxidations of substituted phenols. Despite almost four decades of intense experimental and theoretical research, the factors governing the diverse reactivity of CBC enzymes had remained only partially understood. In this review, we highlight the recent synergy between spectroscopy, kinetic experiments, and state-of-the-art computations (including hybrid quantum and molecular mechanical, QM/MM, and advanced wave function theory, WFT, methods) that provided a conclusive mechanistic picture of the initial stages of the hydroxylation of phenolic substrates catalyzed by the CBC enzyme tyrosinase (Ty). We emphasize the power of calibrated theoretical calculations, supported by experimental spectroscopic and kinetic data on intermediates, in providing definitive insight into the catalytic reaction coordinate. We provide a critical review of previous efforts towards elucidating structure-function correlations over the four CBC protein classes (hemocyanins, catechol oxidases, tyrosinases, -aminophenol oxygenases). We outline how a systematic mechanistic understanding across the different CBC enzyme classes could uncover their elusive structure-function correlations, opening new possibilities for utilizing the [CuO] catalytic core outside its native biological context for applications in materials and biocatalysis.
-
10. Functional utility of gold complexes with phosphorus donor ligands in biological systems.
10. 含磷给体配体的金配合物在生物系统中的功能效用PMID:日期:2024-09-27Metallo-phosphines are ubiquitous in organometallic chemistry with widespread applications as catalysts in various chemical transformations, precursors for organic electronics, and chemotherapeutic agents or chemical probes. Here, we provide a comprehensive review of the exploration of the current biological applications of Au complexes bearing phosphine donor ligands. The goal is to deepen our understanding of the synthetic utility and reactivity of Au-phosphine complexes to provide insights that could lead to the design of new molecules and enhance the cross-application or repurposing of these complexes.