CHEMISTRY AND PHYSICS OF LIPIDS脂质化学与物理
CHEMISTRY AND PHYSICS OF LIPIDS(英文缩写 CHEM PHYS LIPIDS),ISSN 0009-3084,eISSN 1873-2941,中文译名:脂质化学与物理 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-09-27 至 2026-09-27，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 3.570 | Q2 |
| 2022 | 3.400 | Q2 |
| 2023 | 3.400 | Q1 |
| 2024 | 2.800 | Q2 |
| 2025 | 3.000 | Q2 |
CHEMISTRY AND PHYSICS OF LIPIDS 最新收录文献
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1. Understanding charged polymer-lipid interactions in model membranes revealed by EPR and solid-state NMR: Implications for membrane protein studies.
PMID:日期:2026-08-22Polymers such as Styrene Maleic Acid (SMA) have become valuable tools for studying membrane proteins within lipid bilayers due to their ability to solubilize membrane proteins in their native environments. However, limitations in the use of SMA copolymers have led to the development of SMA derivatives. In this study, we investigate the impact of the charge properties of several SMA derivatives on various lipid systems, which may also carry charges. We employed neutral, positively charged, and negatively charged SMA-derivative copolymers (SMA-Neut, SMA-Pos, SMA-AE, SMA Glu, and SMA-BZ30) to investigate their impact on bilayers composed of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol (POPG), and a 9:1 molar ratio mixture of POPC and POPG. No single technique, however, is effective across the wide array of different MPs, and there are often significant discrepancies between structures determined by different methods if the protein's environment is far from a native lipid bilayer. In this study, we utilized biophysical techniques, including dynamic light scattering (DLS), electron paramagnetic resonance (EPR) spectroscopy, and solid-state nuclear magnetic resonance (ssNMR) spectroscopy, to analyze the interactions between polymers and lipid bilayers. Our EPR findings indicate that all the polymers preserved the POPC/POPG lipid bilayer. Meanwhile, our ssNMR result analysis suggests that neutral polymers may disrupt the bilayer less than charged polymers do. This implies that the electrostatic interactions between charged polymers and lipids can significantly alter the native environment of the bilayer, potentially impacting the stability and dynamics of encapsulated membrane proteins. Although this work primarily focuses on lipid systems, our results underscore the importance of considering polymer-lipid electrostatic interactions when selecting SMA derivatives and polymers for biophysical studies of membrane proteins, as the choice of polymer can profoundly affect the integrity and behavior of the lipid bilayer system.
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2. Sodium-Induced Lipid Bilayer Phase Transition for an Ester Lipid and Phase Transition Resistance for an Ether Branched-Lipid.
PMID:日期:2026-08-13Environmental factors such as temperature and ion concentration can induce the phase transition from the liquid-crystalline to gel phase. In our work, we investigate the effect of temperatures and NaCl concentrations on phase transitions for two model lipids, i.e., an ether linked lipid with methyl branches (phosphatidyl glycerophosphate methyl ester, PGP-Me) and a more common ester phospholipid (dimyristoylphosphatidylcholine, DMPC). At 5.0M NaCl 30C, the temperature closest to DMPC's phase transition temperature (T) in pure water, DMPC experiences a phase transition, but PGP-Me does not. Since PGP-Me is a model lipid for those found in archaea, it suggests that salt resistance for archaea might be related to maintaining a fluid phase at high salt concentrations. This is supported as the lipid surface areas, membrane compressibility, chain order, and electron density profiles all show that at 30C between 0.1M and 5.0M NaCl, PGP-Me has smaller changes than DMPC, meaning that PGP-Me maintains membrane fluidity more effectively. The sn-1 phosphate/carbonyl electrostatic interactions are primarily responsible for the phase transition, while these electrostatic interactions are no longer chain specific in the gel phase. PGP-Me resists the phase transition better than DMPC because its methyl branches prevent tight lipid packing and its ether linkages decrease the interaction with Na ions. These quantitative measurements of the electrostatic interaction types formed during the liquid-crystalline, phase transition, gel phase, and by chain specificity uncover the mechanism of the phase transition induced by Na ions and is confirmed through our machine learning process.
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3. Cleavable Carbosilane Dendrimers Modulate the Thermodynamical Properties of DMPC/DPPG Lipid Membrane and Conformation of Human Serum Albumin.
3. 可切割的碳硅烷树枝状大分子调节DMPC/DPPG脂质膜的热力学性质和人血清白蛋白的构象PMID:日期:2026-08-11Cationic carbosilane dendrimers are promising nonviral vectors for the delivery of drugs and nucleic acids, however, their interaction with bloodstream molecules is incompletely understood. In this study, we investigated the interactions of a novel family of pH-tunable charge cationic carbosilane dendrimers of three generations G1: ArG₁(NMe₂HCl)₆, G2: ArG₂(NMe₂HCl)₁₂ and G3: ArG₃(NMe₂HCl)₂₄ with model 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and 1,2-dipalmitoyl-sn-glycero-3-phosphoglycerol (DPPG) lipid membranes and human serum albumin (HSA), using dynamic light scattering, transmission electron microscopy (TEM), differential scanning calorimetry (DSC), fluorescence spectroscopy, circular dichroism, and isothermal titration calorimetry (ITC). All three kinds of dendrimers formed stable complexes with negatively charged liposomes, inducing generation-dependent changes in hydrodynamic diameter and surface charge. DSC analysis demonstrated that G1 dendrimer destabilized the DMPC/DPPG bilayer in a concentration-dependent manner, perturbing both the polar headgroup region and the hydrophobic hydrocarbon chain region of the membrane. TEM imaging revealed generation-dependent differences in the extent of membrane disruption. Interactions with HSA were confirmed by tryptophan fluorescence quenching and circular dichroism, which showed a generation-dependent decrease in α-helix content indicative of partial protein unfolding. ITC analysis of the G1/HSA interaction demonstrated a spontaneous, exothermic binding process. In conclusion, studied dendrimers interact with both DMPC/DPPG lipid bilayers and HSA in a manner that is generation-dependent (DLS, zeta potential, TEM, CD, fluorescence) and concentration-dependent (DSC, ITC, characterized for the representative G1 dendrimer), suggesting that their generation and charge density are key determinants of their behavior toward biological membranes and plasma proteins.
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4. Analysis of glycosyldiacylglycerols produced by the zoonotic pathogen Streptococcus suis.
PMID:日期:2026-07-27Streptococcus suis is a major swine pathogen with zoonotic potential, responsible for substantial economic losses to the swine industry worldwide. The nature of its bacterial cell wall components and their role in virulence have not been fully elucidated yet. We herein report the isolation and structural characterization of the glycosyldiacylglycerols produced by S. suis. In four selected strains, we show the presence of 1,2-diacyl-3-O-(α-D-glucopyranosyl-(1→2)-α-D-glucopyranosyl)-sn-glycerol and 1,2-diacyl-3-O-(α-D-glucopyranosyl)-sn-glycerol, both frequently found in streptococci and some other bacteria. In addition, 1,2-diacyl-3-O-(β-D-galactofuranosyl)-sn-glycerol was identified in all investigated strains, a molecule only rarely described in other streptococci and so far not in other bacterial species. Enzymes putatively involved in the biosynthesis of these glycosyldiacylglycerols were identified by BLASTP homology search. Genes encoding these enzymes showed an important degree of conservation across a global S. suis strain collection, with BLASTN analysis revealing high nucleotide identity (mean 94.7-99.2%) and consistent near-complete query coverage. Together, these findings suggest that glycosyldiacylglycerol biosynthesis is broadly maintained across S. suis.
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5. The impact of avobenzone and oxybenzone on fibroblast and keratinocyte membranes. Searching for the role of lipids in the effect of UV filters on skin cells.
PMID:日期:2026-06-05In this work, the effects of two UV filters - avobenzone and oxybenzone - on the membranes of fibroblasts and keratinocytes in ex vivo model systems (Langmuir monolayers) and cell line experiments were examined. The goal of these studies was to analyze the significance of lipid structures in the mechanism of UV filter-induced toxicity to skin cells. Monolayers composed of lipids characteristic of mammalian cell membranes - namely phosphatidylcholine (SOPC), sphingomyelin (SM), cholesterol (Chol) and ceramides (Ceramide 22 and Ceramide 17) - were used as model systems. Both mixed monolayers mimicking fibroblast and keratinocyte membranes and one-component lipid films were investigated. The surface pressure/area measurements and penetration studies were done, and Brewster angle microscopy was applied to verify the morphology of the studied systems. It was found that avobenzone has a stronger impact on molecular organization of skin cell model membranes than oxybenzone; however, its effect is concentration-limited. Both UV filters exhibited stronger affinity to Chol, SM and SOPC monolayers than to ceramides, which are the lipids characteristic for skin cells. Therefore, it can be suggested that ceramides may hinder the penetration of UV filter molecules into the interior of skin cells. Cell line model studied with SEM microscopy suggested that UV filters alter the skin cell membrane. Finally, it was summarized that the mechanism of UV filter toxicity is complex, but one of its important elements is the impact on the organization of lipid structures.
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6. Emerging roles of dehydrogenase/reductase (DHRS) in cancer.
PMID:日期:2026-06-01As a member of short-chain dehydrogenase/reductase (SDR) superfamily, dehydrogenase/reductase (DHRS) is mainly involved in the metabolism of many substrates such as lipids, steroids and retinol. The DHRS family comprises more than 12 members, including DHRS1 - 4, DHRS6 - 13, among others. Several members have been extensively studied and implicated in tumorigenesis and cancer progression, such as DHRS2 involved in lipid metabolism, DHRS3/4/9/13 mediating all-trans retinoic acid biosynthesis, DHRS8/10/11 regulating steroid metabolism and DHRS6 maintaining intracellular iron homeostasis. Although the functions of other DHRS members remain poorly characterized, emerging evidence also suggests their association with cancer. Here, we provide an overview of the DHRS family members and highlight their roles in cancer progression.
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7. Molecular dynamics insights into lipid bilayer electroporation under constant versus pulsed DC electric fields.
PMID:日期:2026-06-01Electroporation refers to the formation of pores in the membranes of cells or vesicles induced by an electric field. This technique is widely applied in gene therapy, drug delivery, cancer treatment, and molecular biology to enhance the uptake of nucleic acids, proteins, or drugs into cells by temporarily permeabilizing their membranes using an electric field. In this report, we have investigated pore dynamics in charged, neutral, and cholesterol-containing membranes under constant and pulsating direct current (DC) electric fields of 0.3 V/nm using molecular dynamics (MD) simulations, and we have presented a comparative analysis of the resulting pore behaviors. Under a constant DC electric field, pore opening occurred faster than pore closing. In contrast, under a pulsating DC field, the pore opening time was longer than the pore closing time. Additionally, the cholesterol-containing bilayer required a longer time to initiate pore formation compared to charged and neutral membrane systems. Moreover, the pulsating DC electric field-induced poration time was longer compared to the constant DC field-induced poration time for charged, neutral, and cholesterol-containing membranes. At the moment of pore formation, the solvent accessible surface area, the number of hydrogen bonds, dipole moment, and dielectric constant for all the models rapidly increased, which helped to elucidate precisely the pore dynamics. These findings might be helpful in design a more effective membrane-based electroporation techniques that have significant biotechnological and biomedical applications.
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8. 7-ketocholesterol as a theranostic target: Potential applications and future perspectives.
PMID:日期:2026-06-017-Ketocholesterol (7KC) is mainly formed by cholesterol autoxidation and is a pro-oxidant and pro-inflammatory bioactive lipid that also induces different types of cell death, including oxiapoptophagy. It is frequently associated with major age-related diseases, such as cardiovascular diseases, age-related macular degeneration, and Alzheimer's disease. 7KC can therefore be considered a biomarker for these diseases, offering the possibility of developing theranostic strategies combining diagnosis and treatment. Currently, all the elements are in place to develop tools for the design of theranostic therapies targeting 7KC in diseased organs: antibodies, nanoparticles used as nanoplatforms, molecules that neutralize 7KC such as enzymes which degrade it, as well as natural or synthetic compounds that inhibit the cytotoxic signaling pathways associated with oxidative stress, inflammation and cell death activated by 7KC. Identifying and neutralizing 7KC biological activities using a theranostic approach could also be of interest for growing medical fields such as space medicine widely concerned by oxidative stress, aging and age-related diseases, driven by microgravity. This review supports that most of key tools are now available to develop theranostic treatments targeting 7KC in age-related pathologies, especially in cardiovascular diseases associated with atheroma, but also in age-related macular degeneration and Alzheimer's disease. Discovery of effective treatments for these diseases is a major challenge and will answer an important need for both patients and caregivers.
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10. Review of lipid bilayer structure.
PMID:日期:2026-06-01The structure of well-hydrated, single-component, lipid bilayers is reviewed. Definitions are provided for the parameters that describe structure at various levels of refinement. Comparisons in the structure are made for lipids with different head groups and hydrocarbon chains. Experimental methods include x-ray scattering, neutron scattering, NMR, and densimetry. Interpretation of the scattering experiments is reviewed in some detail and critically examined. Comparison is made to structural parameters obtained from simulations. Chain disordered fluid phase structure is compared to chain ordered gel phase structure, and other chain ordered structures are also briefly reviewed. Even for these simple lipid bilayers, some structural aspects remain unresolved and await further research.