AMERICAN JOURNAL OF VETERINARY RESEARCH美国兽医研究杂志
AMERICAN JOURNAL OF VETERINARY RESEARCH(英文缩写 AM J VET RES),ISSN 0002-9645,eISSN 1943-5681,中文译名:美国兽医研究杂志 是一本学术期刊。本页汇总该期刊的最新影响因子、分区信息以及最新收录于 PubMed 的文献,帮助您快速了解期刊全貌。
发文量统计区间：2025-11-01 至 2026-10-31，按本站收录文献的发表日期统计。
期刊介绍
历年影响因子趋势
| JCR 数据年份 | 影响因子 | JCR 分区 |
|---|---|---|
| 2021 | 1.055 | Q3 |
| 2022 | 1.000 | Q3 |
| 2023 | 1.300 | Q2 |
| 2024 | 1.400 | Q2 |
| 2025 | 1.600 | Q2 |
AMERICAN JOURNAL OF VETERINARY RESEARCH 最新收录文献
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1. Computed tomography perfusion parameters may aid preoperative differentiation of canine pheochromocytomas from adrenocortical tumors.
1. 计算机断层扫描灌注参数可能有助于术前鉴别犬嗜铬细胞瘤与肾上腺皮质肿瘤PMID:日期:2026-09-30To characterize CT perfusion (CTP)-derived time to highest observed adrenal tissue enhancement (T-peak) and arterial blood flow (AF), evaluate associations with triple-phase CT findings, and assess the diagnostic performance of T-peak, AF, and the tumor-to-contralateral adrenal AF ratio for differentiating pheochromocytomas from adrenocortical tumors. Historical CTP data from 5 healthy Beagles served as controls. Client-owned dogs evaluated from November 21, 2024, through May 31, 2026, underwent triple-phase CT, CTP, adrenalectomy, and histopathology. Time to highest observed adrenal tissue enhancement was the interval from contrast administration to the greatest sampled adrenal attenuation; AF was calculated with a single-input maximum-slope model. 20 dogs with 22 tumors (8 adrenocortical adenomas, 7 adrenocortical carcinomas, and 7 pheochromocytomas [PHEOs]) were included. Time to highest observed adrenal tissue enhancement was longer in both adrenocortical tumor groups than in PHEOs; a post hoc cutoff < 36.0 seconds yielded apparent 100% sensitivity and specificity. Arterial blood flow was lower in both adrenocortical tumor groups than in controls and higher in PHEOs than in adrenocortical carcinomas. Arterial blood flow had an area under the curve of 0.923; a cutoff > 100.60 mL/min/100 mL yielded apparent 85.7% sensitivity and 100% specificity. Among 17 dogs with unilateral tumors, the tumor-to-contralateral AF ratio completely separated PHEOs from adrenocortical tumors. Arterial blood flow correlated positively with CT wash-in and washout indices, whereas T-peak correlated negatively with arterial- and venous-phase percentage enhancement washout. Time to highest observed adrenal tissue enhancement and AF differed among adrenal tumor types and were associated with CT enhancement characteristics. Computed tomography perfusion may provide adjunctive information for preoperative adrenal tumor characterization, but the proposed thresholds require validation in larger independent cohorts.
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2. Calf-related environments are reservoirs of Salmonella enterica on northeastern United States dairy farms with a history of endemic Salmonella Dublin infection.
2. 在美国东北部有地方性都柏林沙门氏菌感染史的奶牛场中，与犊牛相关的环境是肠道沙门氏菌的储存库PMID:日期:2026-09-30To identify calf-related environmental reservoirs of Salmonella Dublin on 25 dairy farms with a history of endemic infection in the northeastern US. We hypothesized that maternity pens and calf housing areas were reservoirs of S Dublin on such farms. We used real-time PCR to detect Salmonella enterica in samples collected from dairy farm environments and subsequently cultured PCR-positive samples. All confirmed S Dublin isolates were subjected to antimicrobial susceptibility testing and whole-genome sequencing. A mixed-effects logistic regression model was used to evaluate the association between farm location and PCR positivity. Of the 678 environmental samples collected, 50.1% were PCR positive for S enterica. A mixed-effects logistic regression model revealed calf-related equipment (OR, 2.7; 95% CI, 1.4 to 3.7) and maternity pen areas (OR, 6.2; 95% CI, 4.0 to 9.8) to have increased odds of testing Salmonella PCR positive in comparison to calf housing areas. Additionally, we isolated and antigenically confirmed S Dublin from maternity pens and calf housing areas. Core genome variation assessment of these isolates revealed high genetic similarity to human isolates. The results demonstrate that maternity pens and calf housing areas can harbor S Dublin. Additionally, phylogenetic analysis highlights the potential for this pathogen to spread among human, animal, and environmental reservoirs. Identifying maternity pens and calf housing areas as reservoirs of S Dublin can inform the development of targeted hygiene and biosecurity protocols for dairy herds with endemic infection.
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3. Portable blood glucose meters do not reliably detect hypoglycemia in ferrets (Mustela putorius furo) compared with a point-of-care chemistry analyzer.
PMID:日期:2026-09-30To compare blood glucose concentrations measured by a veterinary portable blood glucose meter (v-PBGM; AlphaTrak3; Zoetis Inc), a human portable blood glucose meter (h-PBGM; FreeStyle Precision Neo; Abbott Diabetes Care), and a point-of-care chemistry analyzer (reference analyzer; VetScan VS2; Zoetis Inc) in client-owned ferrets. Residual heparinized jugular venous blood samples from ferrets undergoing unrelated veterinary evaluations were analyzed from June 2025 through April 2026 within 10 minutes of collection. Blood glucose was measured with the h-PBGM and with the v-PBGM using equine, canine, and feline settings. Agreement was assessed by Bland-Altman analysis and at hypoglycemia thresholds of ≤ 60 and < 70 mg/dL. 24 client-owned domestic ferrets (Mustela putorius furo) were included. Mean blood glucose concentration by the reference analyzer was 90.8 mg/dL (range, 43 to 157 mg/dL). The h-PBGM had the greatest positive fixed bias. The v-PBGM canine and feline settings showed minimal fixed bias, but all glucometers had wide limits of agreement. At the ≤ 60-mg/dL threshold, simple classification agreement was 79% for the canine and feline settings, 75% for the equine setting, and 58% for the h-PBGM. The v-PBGM canine and feline settings agreed more closely with the reference analyzer than did the h-PBGM. However, agreement was insufficient to support diagnosis or management of hypoglycemia based solely on portable glucometer results in ferrets. Low, borderline, unexpected, or treatment-altering blood glucose results should be confirmed with a point-of-care or reference laboratory chemistry analyzer.
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4. Liposomal bupivacaine local analgesia reduces systemic inflammatory responses following equine laparoscopic surgery.
4. 脂质体布比卡因局部镇痛可减轻马腹腔镜手术后的全身炎症反应PMID:日期:2026-09-29Liposomal local anesthetics have been shown to extend analgesia duration and improve pain scores dose-dependently in horses. Our objective was to assess concurrent impact on systemic inflammatory markers. 18 mares (age, 2 to 20 years) with normal ovarian anatomy were enrolled. Laparoscopic bilateral ovariectomies were performed standing with sedation. Local analgesia was: 80 mL bupivacaine hydrochloride (BHCl; n = 6), 30 mL 0.75% BHCl + 20 mL (low-dose) liposomal bupivacaine (LB) expanded to 80 mL with saline (LB20, n = 6), or 30 mL 0.75% BHCl + 40 mL (high-dose) LB expanded to equal volume around incision sites and mesovarium prior to ovariectomy (LB40, n = 6). Whole blood samples were obtained (0, 0.5, 1, 2, 4, 8, 24, 48, and 72 hours), and plasma was separated. Serum amyloid A (SAA) and 23 cytokines were quantified via commercially available kits and multiplex immunoassay, respectively. SAA increased postoperatively from 24 to 72 hours (548.11 ± 726.84, 957.76 ± 1,006.62, and 841.18 ± 953.4, respectively). Serum amyloid A was lower in the LB40 group versus the LB20 group at 48 hours (303 ± 347.74 vs 773.17 ± 733.19) and 72 hours (439.67 ± 461.53 vs 951.6 ± 1,052.4). Cytokine concentrations were quantifiable for 14 cytokines; differences between groups were seen for eotaxin, granulocyte colony-stimulating factor, and IL-8. No group had consistently higher or lower values. High-dose LB suppressed the systemic inflammatory response, resulting in lower SAA postoperatively following ovariectomy. Infiltration of extended-duration local anesthetics decreased inflammatory responses postoperatively.
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5. Identification and evaluation of repurposing Food and Drug Administration-approved drugs targeting the pE165R protein of African swine fever virus.
5. 靶向非洲猪瘟病毒pE165R蛋白的FDA批准药物重定位的鉴定与评估PMID:日期:2026-09-28African swine fever is a devastating swine disease lacking effective vaccines or antiviral drugs. The African swine fever virus (ASFV) pE165R deoxyuridine triphosphatase (dUTPase), critical for viral replication, is a promising antiviral target. Therefore, identifying inhibitors that target the pE165R protein represents a potential antiviral strategy. The study computationally screened FDA-approved drugs against pE165R's crystal structure. Molecular dynamics simulations elucidated inhibitor-pE165R interactions, and in vitro enzymatic assays quantitatively assessed inhibitory effects. 4 candidates predominantly targeted pE165R's active pocket (Serine-72, Arginine-71, and Serine-73), suggesting competitive inhibition, with strong binding free energies (up to -40.5 kcal/mol) observed by molecular mechanics/Poisson-Boltzmann surface area. In vitro assays confirmed dideoxyinosine triphosphate (77.9%) potently inhibited pE165R activity at 0.1mM. Effective drugs against ASFV remain lacking. Based on a drug-repurposing strategy, this study screened the FDA-approved drug library for compounds targeting pE165R, a key protein involved in ASFV replication. Subsequent pharmacodynamic evaluation is expected to facilitate the identification of affordable and effective anti-ASFV therapeutics for clinical application, thereby providing a theoretical foundation for the effective prevention and control of African swine fever.
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6. Urine Molecular Fingerprinting: exploratory study of a promising technology for detecting cancer and nonneoplastic disease in dogs.
6. 尿液分子指纹图谱：一项用于检测犬类癌症和非肿瘤性疾病的前景广阔技术的探索性研究PMID:日期:2026-09-24To describe a novel technology, Urine Molecular Fingerprinting (UMF), for analyzing the composition of urine and its application for neoplastic/nonneoplastic diseases in dogs. Voided urine samples from clinically healthy Bernese Mountain Dogs (n = 263), Golden Retrievers (214), West Highland White Terriers (79), German Shepherd Dogs (21), and other breeds (245). Samples were analyzed using Raman spectroscopy and computational statistics. To illustrate the clinical relevance of UMF, samples from dogs with cancer (n = 142) or nonneoplastic diseases (19) were analyzed and compared with reference UMF databases of clinically healthy dogs. Breed-associated differences in UMFs were present in samples from clinically healthy Bernese Mountain Dogs, Golden Retrievers, German Shepherd Dogs, and West Highland White Terriers. The UMFs of purebred dogs were different from those of a cohort of mixed breed/other purebred dogs. There were no UMF differences associated with age, sex, or neutering status in Bernese Mountain Dogs. The Raman intensity profiles of UMFs from dogs with cancer or nonneoplastic diseases were different from UMFs of clinically healthy dogs. Preliminary, exploratory studies indicate that UMF is a promising technology for detecting cancer and nonneoplastic disease in dogs. Urine Molecular Fingerprinting may be useful in the detection of cancer and nonneoplastic diseases in dogs. This technology could be adapted for testing in clinics, supplementing clinical, laboratory, and imaging information used for health assessments. The use of liquid biopsy technology, such as UMF, in canine cancer detection is addressed in the companion Currents in One Health by Robertson et al, JAVMA, June 2026.
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7. Feasibility of the ForeSight tissue oximetry system for estimating cerebral and renal tissue oxygen saturation in anesthetized dogs during hyperoxia, normoxia, and hypoxia.
7. ForeSight组织血氧测量系统在高氧、常氧和低氧条件下估计麻醉犬脑组织和肾组织氧饱和度的可行性PMID:日期:2026-09-24To evaluate the feasibility of the ForeSight tissue oximetry system for assessing regional cerebral and renal tissue oxygen saturation in anesthetized dogs across 3 oxygenation states. 6 anesthetized Beagles were included. ForeSight tissue oximetry sensors were applied to the cranium and left lateral abdomen to estimate regional cerebral oxygen saturation (rScO2) and regional renal oxygen saturation (rSrO2). The left dorsal pedal artery, right femoral vein, and right jugular vein were cannulated for arterial and venous blood sampling. The distal tips of the jugular and femoral venous catheters were positioned in the renal vein and the most cranial aspect of the internal jugular vein. During hyperoxia, normoxia, and hypoxia, 1-mL blood samples were collected simultaneously from all 3 sites and analyzed using a blood gas analyzer. Weighted reference oxygenation values (REF-CXB) were calculated. Correlation and agreement between REF-CXB and rScO2 or rSrO2 were assessed using repeated-measures correlation and Bland-Altman analyses. rScO2 demonstrated moderate correlation with cerebral REF-CXB (r = 0.70; P < .01) but poor agreement. In contrast, rSrO2 showed no correlation with renal REF-CXB (r = 0.09; P = .62) and poor agreement. rScO2 demonstrated moderate correlation with the blood gas-derived cerebral oxygen saturation reference estimate in anesthetized dogs, whereas rSrO2 did not reliably reflect the corresponding renal oxygen saturation reference estimate. Trend monitoring of cerebral oxygenation with the ForeSight system may provide an adjunctive tool for real-time assessment of cerebral oxygenation in dogs undergoing general anesthesia.
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8. Hemoadsorption with the Cytosorb adsorber can effectively reduce cell-free hemoglobin from porcine blood in vitro.
8. 使用Cytosorb吸附器进行血液吸附可以有效降低体外猪血中的无细胞血红蛋白PMID:日期:2026-09-24The aim of this study was to investigate the maximum capacity of the Cytosorb adsorber for clearance of cell-free hemoglobin (cfHb) in a porcine cfHb solution in vitro. Anticoagulated porcine blood was centrifuged to separate plasma from RBCs. Red blood cell concentrate was stored in the freezer, thawed, and mixed with distilled water to achieve complete hemolysis. The cfHb solution was divided into 12 aliquots of 1,000 mL each. Six test runs were performed in a circular setup with the Cytosorb adsorber. Samples were collected before and after adsorber. After 20 L of processed cfHb solution, the storage bottle was exchanged, and a new storage bottle with 1,000 mL of the cfHb solution with the initial cfHb concentration was processed for another 10 L. The initial median cfHb concentration of the porcine cfHb solution of 4.13 mmol/L (4.03 to 4.22 mmol/L) decreased to 2.70 mmol/L (2.54 to 2.79 mmol/L) after processing 20 L of cfHb solution. This corresponds to a median cfHb reduction of 22.1 g (21.9 to 27.1 g), which was primarily achieved during the first 10.0 L of processed cfHb solution. In the second storage bottle, no further relevant cfHb concentration decrease was achieved. Hemoadsorption using the Cytosorb adsorber effectively reduced cfHb concentration from a porcine cfHb solution in vitro. The maximum adsorption capacity of the Cytosorb adsorber for this experimental setup was about 22.1 g. The Cytosorb adsorber might be a promising tool for removal of cfHb from the circulation in vivo.
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9. Lipopolysaccharide induces a delayed iron-handling transcript pattern in primary bovine macrophages.
9. 脂多糖在原代牛巨噬细胞中诱导延迟的铁处理转录模式PMID:日期:2026-09-23To characterize the timing and between-cow consistency of iron-handling transcript changes after lipopolysaccharide (LPS) exposure in primary bovine monocyte-derived macrophages. Macrophages from 5 adult Holstein donor cows were exposed to Escherichia coli LPS or PBS and profiled by RNA sequencing at 30 minutes and 6 hours in a paired design. The LPS-versus-PBS effects were estimated with cow-blocked negative-binomial models. Per-cow direction was examined, and 4 focal transcripts were compared directionally with a separate published cohort of 8 cattle sampled 48 hours after LPS exposure. A treatment-by-time interaction was detected for 5,461 genes. At 6 hours, transferrin receptor, STEAP3 metalloreductase, and solute carrier 11A2 transcripts increased by 2.61, 1.46, and 2.47 log2 fold, respectively, whereas solute carrier 40A1 decreased by 2.24 log2 fold. All 4 changes had the same direction in each of the 5 cows. The separate cohort showed the same direction for all 4 transcripts (transferrin receptor in 7 of 8 animals; the other genes in 8 of 8); its different protocol precluded kinetic replication. LPS exposure was associated with a later, cow-consistent pattern of increased iron acquisition-associated transcripts and decreased ferroportin transcript abundance. The study does not establish protein abundance, cellular iron movement, or hepcidin dependence. These transcript-level measures provide an ex vivo framework for studying variation in bovine macrophage iron-handling responses.
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10. Scientific influence on the rise: 2025 impact factors for JAVMA and AJVR.
PMID:日期:2026-09-21该文献暂无摘要。