一种黏附性水凝胶实现脐带外泌体的时空递送，通过免疫调节和细胞外基质重塑促进无瘢痕皮肤再生
An adhesive hydrogel enabling spatiotemporal delivery of umbilical cord exosomes for scarless skin regeneration through immunomodulation and ECM remodeling.
摘要(中文译文)
全层皮肤缺损的再生修复仍是临床上的重大挑战，常导致病理性瘢痕形成，因为传统敷料缺乏在牢固黏附与力学顺应性之间取得平衡并主动引导组织再生的功能。为解决这一问题，我们提出了一种黏附性双网络水凝胶（GelMA-PBA/HANB/HepMA），通过动态硼酸酯键与光触发亚胺交联的协同整合构建，同时作为智能储库持续递送脐带来源外泌体（uExos）。该系统通过极化巨噬细胞向促愈合表型并增强内皮血管生成，营造促再生微环境，从而在小鼠全层缺损模型中加速伤口闭合与再上皮化。关键在于，在严格的兔耳增生性瘢痕模型中，该治疗显著降低了瘢痕隆起指数（SEI）并恢复了生理性胶原结构，表现为Col III/I比值升高和隆起角度减小。重要的是，uExos通过参与细胞外基质重塑和平衡胶原沉积促进无瘢痕愈合。通过将智能黏附材料与无细胞外泌体治疗策略性结合，本研究为再生性伤口愈合和瘢痕预防提供了一种有前景的策略。
Abstract
The regenerative repair of full-thickness skin defects remains a formidable clinical challenge, often culminating in pathological scarring because conventional dressings lack the functionality to balance robust adhesion with mechanical compliance and actively direct tissue regeneration. To address this, we propose an adhesive dual-network hydrogel (GelMA-PBA/HANB/HepMA) via the synergistic integration of dynamic boronic ester bonds and photo-triggered imine crosslinking, while serving as a smart depot for sustained delivery of umbilical cord-derived exosomes (uExos). This system orchestrates a pro-regenerative niche by polarizing macrophages to a pro-healing phenotype and enhancing endothelial angiogenesis, thereby accelerating wound closure and re-epithelialization in a mouse full-thickness defect model. Crucially, in a rigorous rabbit ear hypertrophic scar model, treatment significantly reduces the Scar Elevation Index (SEI) and restores a physiological collagen architecture, evidenced by an increased Col III/I ratio and reduced bulge angle. Importantly, uExos promote scarless healing involved in extracellular matrix remodeling and balanced collagen deposition. By strategically combining smart adhesive materials with cell-free exosome therapy, this study offers a promising strategy for regenerative wound healing and scar prevention.
如何引用
AMA
Yiqiu Zhang, Jia Xie, Jianghan Li, Fupeng Li, Zheng Ci, Jian Wang, et al. An adhesive hydrogel enabling spatiotemporal delivery of umbilical cord exosomes for scarless skin regeneration through immunomodulation and ECM remodeling.. Bioactive materials. 2027; doi:10.1016/j.bioactmat.2026.08.033.
APA
Yiqiu Zhang, Jia Xie, Jianghan Li, Fupeng Li, Zheng Ci, Jian Wang, et al (2027). An adhesive hydrogel enabling spatiotemporal delivery of umbilical cord exosomes for scarless skin regeneration through immunomodulation and ECM remodeling.. Bioactive materials. https://doi.org/10.1016/j.bioactmat.2026.08.033
GB/T 7714
Yiqiu Zhang, Jia Xie, Jianghan Li, Fupeng Li, Zheng Ci, Jian Wang, et al. An adhesive hydrogel enabling spatiotemporal delivery of umbilical cord exosomes for scarless skin regeneration through immunomodulation and ECM remodeling.[J]. Bioactive materials, 2027 doi:10.1016/j.bioactmat.2026.08.033.
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