迷走神经亚回路差异性调控脓毒症诱导的疾病行为和焦虑相关行为
Vagal subcircuits differentially regulate sepsis-induced sickness and anxiety-related behaviors.
摘要(中文译文)
大脑通过迷走神经感觉神经元监测外周免疫活动，这些神经元的胞体位于结状神经节，并投射至脑干背侧迷走复合体。这一中继激活了介导感染相关行为变化（如疾病行为）的神经回路。在脓毒症等严重炎症中，这种信号传导可导致脑功能障碍，包括持续性焦虑。利用盲肠结扎穿刺的啮齿动物脓毒症模型，我们通过整合手术和化学遗传学功能获得与功能缺失方法，研究了迷走神经亚回路如何促成这些效应。激活背侧迷走复合体神经元加重了疾病行为并促进了持续性焦虑相关行为，而激活上游结状神经元则无此效应。结状神经节或脑干的暂时性抑制没有影响。然而，膈下迷走神经切断术减少了急性脑激活，并部分减轻了脓毒症存活者的焦虑症状。这些结果凸显了迷走-免疫-脑相互作用的复杂性，并强调了机制性见解对指导靶向治疗开发的重要性。
Abstract
The brain monitors peripheral immune activity via vagus nerve sensory neurons, whose cell bodies lie in the nodose ganglia and project to the brainstem dorsal vagal complex. This relay activates neural circuits mediating infection-related behavioral changes, such as sickness behavior. In severe inflammation like sepsis, this signaling can contribute to brain dysfunction, including persistent anxiety. Using the rodent sepsis model of cecal ligation and puncture, we investigated how vagal subcircuits contribute to these effects, by integrating surgical and chemogenetic gain- and loss-of-function approaches. Activating dorsal vagal complex neurons exacerbated sickness behavior and promoted lasting anxiety-related behavior, while activating upstream nodose neurons did not. Nodose or brainstem transient inhibition had no effect. However, subdiaphragmatic vagotomy reduced acute brain activation and partly attenuated anxiety symptoms in sepsis survivors. These results highlight the complex vagal-immune-brain interplay and emphasize the importance of mechanistic insights to guide the development of targeted therapies.
如何引用
AMA
Lena Bourhy, Carine Moigneu, Alice Dupin, Esteban Delelis, Jarod Levy, Pierre-Marie Lledo, et al. Vagal subcircuits differentially regulate sepsis-induced sickness and anxiety-related behaviors.. Cell reports. 2026; doi:10.1016/j.celrep.2026.117896.
APA
Lena Bourhy, Carine Moigneu, Alice Dupin, Esteban Delelis, Jarod Levy, Pierre-Marie Lledo, et al (2026). Vagal subcircuits differentially regulate sepsis-induced sickness and anxiety-related behaviors.. Cell reports. https://doi.org/10.1016/j.celrep.2026.117896
GB/T 7714
Lena Bourhy, Carine Moigneu, Alice Dupin, Esteban Delelis, Jarod Levy, Pierre-Marie Lledo, et al. Vagal subcircuits differentially regulate sepsis-induced sickness and anxiety-related behaviors.[J]. Cell reports, 2026 doi:10.1016/j.celrep.2026.117896.
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