m6A修饰与代谢重编程在结直肠癌中的交叉对话：从免疫微环境到临床应用
{"_":"Crosstalk between mA modification and metabolic reprogramming in colorectal cancer: from the immune microenvironment to clinical applications.","sup":["6"]}
摘要(中文译文)
N6-甲基腺苷（mA）修饰是真核生物mRNA中最常见的表观遗传改变，通过动态调控RNA代谢过程，显著影响结直肠癌（CRC）的代谢重编程和肿瘤微环境（TME）。近期研究表明，mA修饰与CRC代谢重编程相互作用，促进免疫抑制性TME的形成。具体而言，mA修饰通过调控葡萄糖、脂质和氨基酸代谢促进CRC进展，同时抑制抗肿瘤免疫细胞（如T细胞、自然杀伤细胞和巨噬细胞）的活性，并激活肿瘤免疫抑制细胞（包括肿瘤相关巨噬细胞、髓源性抑制细胞、调节性T细胞、肿瘤相关中性粒细胞和癌相关成纤维细胞）。本文系统综述了mA修饰通过代谢调控驱动CRC恶性进展的分子机制，阐明了涉及mA修饰的代谢网络及其在塑造TME中的作用，并探讨了靶向mA修饰和/或代谢途径的临床潜力，为CRC治疗提供了新的研究方向。
Abstract
N6-methyladenosine (mA) modification is the most common epigenetic alteration in eukaryotic mRNA, significantly impacting metabolic reprogramming and the tumor microenvironment (TME) of colorectal cancer (CRC) by dynamically regulating RNA metabolic processes. Recent studies indicate that mA modification interacts with CRC metabolic reprogramming, fostering an immunosuppressive TME. Specifically, mA modification promotes CRC progression by regulating glucose, lipid, and amino acid metabolism while inhibiting the activity of antitumor immune cells (such as T cells, natural killer cells, and macrophages) and activating tumor immunosuppressive cells (including tumor-associated macrophages, myeloid-derived suppressor cells, regulatory T cells, tumor-associated neutrophils, and cancer-associated fibroblasts). This article systematically reviews the molecular mechanisms through which mA modification drives the malignant progression of CRC via metabolic regulation, elucidates the metabolic network involving mA modification and its role in shaping TME, and discusses the clinical potential of targeting mA modification and/or metabolic pathways, offering novel research avenues for CRC treatment.
如何引用
AMA
Liang Zhao, Zhitao Yin, Chenchun Ji, Yan Wu, Hongjian Gao, Hexue Yuan. {"_":"Crosstalk between mA modification and metabolic reprogramming in colorectal cancer: from the immune microenvironment to clinical applications.","sup":["6"]}. Frontiers in immunology. 2026; doi:10.3389/fimmu.2026.1911067.
APA
Liang Zhao, Zhitao Yin, Chenchun Ji, Yan Wu, Hongjian Gao, Hexue Yuan (2026). {"_":"Crosstalk between mA modification and metabolic reprogramming in colorectal cancer: from the immune microenvironment to clinical applications.","sup":["6"]}. Frontiers in immunology. https://doi.org/10.3389/fimmu.2026.1911067
GB/T 7714
Liang Zhao, Zhitao Yin, Chenchun Ji, Yan Wu, Hongjian Gao, Hexue Yuan. {"_":"Crosstalk between mA modification and metabolic reprogramming in colorectal cancer: from the immune microenvironment to clinical applications.","sup":["6"]}[J]. Frontiers in immunology, 2026 doi:10.3389/fimmu.2026.1911067.
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