一种具有多功能特性的葡萄糖响应性水凝胶，用于加速糖尿病伤口愈合

摘要(中文译文)

糖尿病伤口的特点是在持续高血糖条件下存在氧化应激、慢性炎症和组织再生受损。在此，我们报道一种由苯硼酸功能化氧化海藻酸钠与没食子酸偶联壳聚糖制备的可注射双动态共价水凝胶。该水凝胶通过可逆的席夫碱键和硼酸酯键交联，表现出优异的可注射性、自愈合能力和结构稳定性。在高血糖条件下，竞争性葡萄糖结合可调节硼酸酯平衡，并诱导含没食子酰基物质的葡萄糖响应性释放。这些葡萄糖响应性释放行为有助于水凝胶的抗氧化、抗菌和免疫调节活性。体外和体内结果表明，该水凝胶促进巨噬细胞向抗炎M2表型极化，减轻炎症反应，增强血管生成，并加速皮肤再生。总体而言，苯硼酸功能化氧化海藻酸钠与没食子酸偶联壳聚糖水凝胶是一种多功能葡萄糖响应性生物材料，在糖尿病伤口治疗方面具有相当大的潜力。

Abstract

Diabetic wounds are characterized by oxidative stress, chronic inflammation, and impaired tissue regeneration under persistent hyperglycemic conditions. Herein, we report an injectable dual-dynamic covalent hydrogel fabricated from phenylboronic-acid-functionalized oxidized sodium alginate and gallic-acid-conjugated chitosan. Crosslinked via reversible Schiff base and boronate ester bonds, the hydrogel exhibits excellent injectability, self-healing capability, and structural stability. Under hyperglycemic conditions, competitive glucose binding modulates the boronate ester equilibrium and induces glucose-responsive release of galloyl-containing species. These glucose-responsive release behaviors contribute to the antioxidant, antibacterial, and immunoregulatory activities of the hydrogel. In vitro and in vivo results demonstrate that the hydrogel promotes macrophage polarization toward the anti-inflammatory M2 phenotype, alleviates inflammatory responses, enhances angiogenesis, and accelerates skin regeneration. Collectively, the phenylboronic-acid-functionalized oxidized sodium alginate and gallic-acid-conjugated chitosan hydrogel represents a multifunctional glucose-responsive biomaterial with considerable potential for diabetic wound therapy.

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