评估子痫前期和健康孕妇纤维蛋白原与白蛋白比值与疾病严重程度之间的关系
Evaluation of the Relationship between Fibrinogen-to-Albumin Ratio and Disease Severity in Preeclamptic and Healthy Pregnant Women.
摘要(中文译文)
本研究旨在确定纤维蛋白原与白蛋白比值（FAR）及血尿素氮与白蛋白比值（BAR）对妊娠早期并发子痫前期的预测价值。此外，本研究还评估了上述指标与疾病严重程度及围产期复合不良结局（CAPO）之间的关系。本回顾性横断面研究纳入144例孕周在20至39周之间的孕妇，分为三组：轻度子痫前期组（n=48）、重度子痫前期组（n=48）及血压正常的健康对照组（n=48）。采用妊娠早期血样计算FAR和BAR值。对各组进行比较，并评估这些指标与疾病严重程度及CAPO的关系。与对照组相比，轻度和重度子痫前期队列的FAR和BAR值均显著升高（p < 0.001）。然而，轻度与重度子痫前期亚组之间的FAR和BAR值差异无统计学意义（p > 0.05）。ROC分析显示，这两种标志物对子痫前期的检测具有中等至较高的诊断效能。然而，FAR和BAR与围产期复合不良结局（CAPO）的发生均无统计学显著性（p > 0.05）。FAR和BAR被认为是可能有助于妊娠早期及时诊断子痫前期的生物标志物。然而，由于这些标志物在预测疾病严重程度或围产期不良结局方面未显示出显著优势，仍需在更大规模的前瞻性队列中进一步研究。
Abstract
The aim of this study was to determine the predictive value of fibrinogen-to-albumin ratio (FAR) and blood urea nitrogen-to-albumin ratio (BAR) in pregnancies complicated by preeclampsia in the first trimester. Furthermore, the study evaluated their relationship with disease severity and composite perinatal adverse outcomes (CAPO). The present retrospective cross-sectional study comprised 144 pregnant women with gestational ages between 20 and 39 weeks, who were divided into three groups: mild preeclampsia (n = 48), severe preeclampsia (n = 48), and a normotensive healthy control group (n = 48). The first trimester blood samples were utilized to calculate the FAR and BAR values. Comparisons were made between the groups, and the relationship of these indices with disease severity and CAPO was evaluated. FAR and BAR values were considerably elevated in both the mild and severe preeclampsia cohorts in comparison to the control group (p < 0.001). However, there were no statistically significant differences in FAR and BAR values between the mild and severe preeclampsia subgroups (p > 0.05). ROC analysis yielded moderate to high diagnostic performance for both markers in the detection of preeclampsia. Nevertheless, both FAR and BAR exhibited a lack of statistical significance in relation to the occurrence of composite perinatal adverse outcomes (CAPO), with p > 0.05. FAR and BAR have been identified as biomarkers that may facilitate the timely diagnosis of preeclampsia in the first trimester of pregnancy. However, since these markers do not demonstrate significant benefits in predicting the severity of the disease or adverse perinatal outcomes, further research is required in larger prospective cohorts.
如何引用
AMA
Özge Öztürk, R Taha Ağaoğlu, A Çiğdem Bayrak, Gülten Çirkin-Tekeş, Dinçer Sümer, Figen Günday, et al. Evaluation of the Relationship between Fibrinogen-to-Albumin Ratio and Disease Severity in Preeclamptic and Healthy Pregnant Women.. Clinical laboratory. 2026; doi:10.7754/Clin.Lab.2025.250826.
APA
Özge Öztürk, R Taha Ağaoğlu, A Çiğdem Bayrak, Gülten Çirkin-Tekeş, Dinçer Sümer, Figen Günday, et al (2026). Evaluation of the Relationship between Fibrinogen-to-Albumin Ratio and Disease Severity in Preeclamptic and Healthy Pregnant Women.. Clinical laboratory. https://doi.org/10.7754/Clin.Lab.2025.250826
GB/T 7714
Özge Öztürk, R Taha Ağaoğlu, A Çiğdem Bayrak, Gülten Çirkin-Tekeş, Dinçer Sümer, Figen Günday, et al. Evaluation of the Relationship between Fibrinogen-to-Albumin Ratio and Disease Severity in Preeclamptic and Healthy Pregnant Women.[J]. Clinical laboratory, 2026 doi:10.7754/Clin.Lab.2025.250826.
在 PubMed增强版 阅读全文
翻译全文 · AI 文献问答 · PDF 原文下载 · 引用导出