T2哮喘的新兴免疫网络和靶向策略
Emerging immune networks and targeted strategies in T2 asthma.
摘要(中文译文)
哮喘是一种高度异质的慢性气道炎症性疾病，其中Th2高型哮喘是最常见的內型。2型（T2）哮喘（由2型炎症驱动）的发病机制涉及一个复杂的免疫网络，该网络由多种效应细胞群的协同作用所编排，包括Th2细胞、2型固有淋巴细胞（ILC2s）和2型细胞毒性T（Tc2）细胞。上皮来源的警报素，特别是白细胞介素-33（IL-33）和胸腺基质淋巴细胞生成素（TSLP），作为连接固有免疫和适应性免疫的关键上游启动因子发挥作用。此外，多层调控机制——包括遗传易感性、代谢重编程和泛素化——共同调控Th2驱动炎症的起始和进展。随着对这些机制理解的深入，治疗策略已逐步从靶向下游效应分子转向靶向上游警报素，从而为精准医学提供了新方向。本综述系统总结了T2哮喘免疫发病机制和靶向治疗的最新进展，为基于精准的临床干预提供了概念框架。
Abstract
Asthma is a highly heterogeneous chronic inflammatory disease of the airways, among which Th2-high asthma represents the most prevalent endotype. The pathogenesis of Type 2 (T2) asthma (driven by type 2 inflammation) involves a complex immune network orchestrated by the coordinated actions of multiple effector cell populations, including Th2 cells, group 2 innate lymphoid cells (ILC2s), and type 2 cytotoxic T (Tc2) cells. Epithelial-derived alarmins, particularly interleukin-33 (IL-33) and thymic stromal lymphopoietin (TSLP), function as key upstream initiators that bridge innate and adaptive immunity. In addition, multilayered regulatory mechanisms-including genetic susceptibility, metabolic reprogramming, and ubiquitination-collectively govern the initiation and progression of Th2-driven inflammation. With the deepening understanding of these mechanisms, therapeutic strategies have progressively shifted from targeting downstream effector molecules to upstream alarmins, thereby providing new directions for precision medicine. This review systematically summarizes recent advances in the immunopathogenesis and targeted therapies of T2 asthma, offering a conceptual framework for precision-based clinical interventions.
如何引用
AMA
Tianye Xi, Tingting Zu, Xinru Pang, Fuling Wu. Emerging immune networks and targeted strategies in T2 asthma.. Frontiers in immunology. 2026; doi:10.3389/fimmu.2026.1868787.
APA
Tianye Xi, Tingting Zu, Xinru Pang, Fuling Wu (2026). Emerging immune networks and targeted strategies in T2 asthma.. Frontiers in immunology. https://doi.org/10.3389/fimmu.2026.1868787
GB/T 7714
Tianye Xi, Tingting Zu, Xinru Pang, Fuling Wu. Emerging immune networks and targeted strategies in T2 asthma.[J]. Frontiers in immunology, 2026 doi:10.3389/fimmu.2026.1868787.
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