健康和疾病中的淋巴管内皮细胞
Lymphatic Endothelial Cells in Health and Disease.
摘要(中文译文)
淋巴管内皮细胞（LECs）衬覆于淋巴管系统，支持组织间液引流、脂质转运及免疫细胞运输。除这些经典功能外，近期研究已认识到LECs是异质性、空间组织化的内皮调节细胞，在维持淋巴管身份的同时呈现组织特异性、节段特异性及疾病相关状态。谱系追踪、多组学、功能成像及扰动研究的进展，现已将LEC异质性与引流控制、免疫监视、抗原处理、代谢稳态及组织修复联系起来。尽管取得了这些进展，目前仍缺乏一个统一框架来解释发育起源、组织微环境及情境依赖性状态转换如何共同塑造LECs在生理和疾病中的功能。在本综述中，我们总结了LEC状态的发育起源、身份维持机制及在淋巴管网络中的解剖学分布。随后，我们讨论了特化LEC状态在稳态下如何协调淋巴运输、免疫监视及外周耐受。我们进一步审视了情境依赖性LEC重编程如何参与淋巴管疾病、炎症与自身免疫、癌症、心血管代谢疾病及中枢神经系统功能障碍。最后，我们强调了靶向LEC转化治疗所面临的挑战与机遇。总之，这一以状态为中心的框架将LECs重新定位为组织稳态和疾病进展的可干预调节者，为精准淋巴医学提供了概念基础。
Abstract
Lymphatic endothelial cells (LECs) line the lymphatic vasculature and support interstitial fluid drainage, lipid transport, and immune-cell trafficking. Beyond these classical functions, recent studies now recognize LECs as heterogeneous, spatially organized endothelial regulators that maintain lymphatic identity while adopting tissue-, segment-, and disease-associated states. Advances in lineage tracing, multiomics, functional imaging, and perturbation studies now link LEC heterogeneity to drainage control, immune surveillance, antigen handling, metabolic homeostasis, and tissue repair. Despite these advances, a unified framework explaining how developmental origin, tissue niche, and context-dependent state transitions collectively shape LEC function across physiology and disease remains lacking. In this review, we summarize the developmental origins, identity-maintenance mechanisms, and anatomical deployment of LEC states across the lymphatic network. We then discuss how specialized LEC states coordinate lymphatic transport, immune surveillance, and peripheral tolerance under homeostasis. We further examine how context-dependent LEC reprogramming contributes to lymphatic disorders, inflammation and autoimmunity, cancer, cardiometabolic disease, and central nervous system dysfunction. Finally, we highlight challenges and opportunities for translational LEC-targeted therapy. Together, this state-centered framework reframes LECs as actionable regulators of tissue homeostasis and disease progression, providing a conceptual foundation for precision lymphatic medicine.
如何引用
AMA
Du Tang, Wang Lin, Hengyang Liu, Jixin Zhong, Shiliang Li, Xiaoquan Rao. Lymphatic Endothelial Cells in Health and Disease.. MedComm. 2026; doi:10.1002/mco2.70891.
APA
Du Tang, Wang Lin, Hengyang Liu, Jixin Zhong, Shiliang Li, Xiaoquan Rao (2026). Lymphatic Endothelial Cells in Health and Disease.. MedComm. https://doi.org/10.1002/mco2.70891
GB/T 7714
Du Tang, Wang Lin, Hengyang Liu, Jixin Zhong, Shiliang Li, Xiaoquan Rao. Lymphatic Endothelial Cells in Health and Disease.[J]. MedComm, 2026 doi:10.1002/mco2.70891.
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