中国哮喘、鼻炎、过敏性多发病率和多药敏反应的趋势：CARRAD研究
Trends in Asthma-Rhinitis Allergic Multimorbidity and Polysensitization in China: The CARRAD Study.
摘要(中文译文)
中国环境变化继发的过敏性共病趋势尚不明确。本研究旨在明确过去十年间哮喘和/或鼻炎患者过敏性共病及多过敏原致敏的变化情况。我们评估了两个具有全国代表性的横断面数据集，分别来自2008—2009年和2018—2019年，各纳入2322例和2353例患者。在本研究的10年期间，2018—2019年队列中多过敏原致敏患者的过敏症状患病率和过敏原敏感率显著高于2008—2009年队列，尤其是尘螨、花粉和动物过敏原。2018—2019年队列中哮喘、过敏性鼻炎、结膜炎和湿疹的共病率显著升高。该队列中，IgE多过敏原致敏与哮喘和鼻炎共存显著相关，IgE反应性过敏原数量与多重共病数量显著相关。家中使用空调、铺设地毯以及饲养宠物与多过敏原致敏风险相关。我们的研究结果提示，中国过敏性疾病的共病率和多重共病多过敏原致敏表型呈增加趋势。两个队列中，哮喘更多以合并过敏性疾病的形式出现，而非作为单一疾病存在。
Abstract
The trends in allergic comorbidities secondary to the environmental variations in China remain unclear. We aimed to determine the variation of allergic comorbidities and polysensitization among asthma and/or rhinitis patients in the past decade. We assessed two nationally representative cross-sectional datasets from 2008 to 2009 and 2018 to 2019, which enrolled 2322 and 2353 patients, respectively. Over the present 10-year study period, the prevalence of allergic symptoms and allergen sensitivity among patients with multiple sensitivities in the 2018-2019 cohort was significantly higher than that in the 2008-2009 cohort, especially for mites, pollen, and animal allergens. The comorbidity rates of asthma, allergic rhinitis, conjunctivitis, and eczema were significantly increased in the 2018-2019 cohort. Also in that cohort, IgE polysensitization was significantly associated with the coexistence of asthma and rhinitis, and the number of IgE-reactive allergens was significantly associated with the number of multimorbidities. Use of an air-conditioner and carpet in the home, and keeping pet were linked to the risk of polysensitization. Our findings suggest an increase in the comorbidity rate and multimorbid polysensitized phenotype of allergic diseases in China. Asthma occurred in both cohorts more frequently with coexisting allergies than as a single entity.
如何引用
AMA
Wanjun Wang, Jianhong Wang, Guihua Song, Hua Xie, Rongfei Zhu, Yong He, et al. Trends in Asthma-Rhinitis Allergic Multimorbidity and Polysensitization in China: The CARRAD Study.. MedComm. 2026; doi:10.1002/mco2.70762.
APA
Wanjun Wang, Jianhong Wang, Guihua Song, Hua Xie, Rongfei Zhu, Yong He, et al (2026). Trends in Asthma-Rhinitis Allergic Multimorbidity and Polysensitization in China: The CARRAD Study.. MedComm. https://doi.org/10.1002/mco2.70762
GB/T 7714
Wanjun Wang, Jianhong Wang, Guihua Song, Hua Xie, Rongfei Zhu, Yong He, et al. Trends in Asthma-Rhinitis Allergic Multimorbidity and Polysensitization in China: The CARRAD Study.[J]. MedComm, 2026 doi:10.1002/mco2.70762.
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