一种具有抗菌和抗氧化性能的多功能粘附水凝胶用于生物界面应用
A Multifunctional Adhesive Hydrogel with Antibacterial and Antioxidant Properties for Biointerface Applications.
摘要(中文译文)
聚硫辛酸（PLA）在生理环境中往往稳定性差、黏附性有限，这限制了其实际应用。为解决这些问题，本研究通过将硫辛酸钠（LANa）和单宁酸（TA）引入体系，构建了一种多组分黏附水凝胶。LANa有助于调节网络的亲水性，而富含酚羟基的TA与聚二硫键链形成广泛的氢键相互作用。这些协同作用有效抑制了二硫键的断裂，增强了材料的整体稳定性。同时，结晶区的破坏使结构更加无定形，赋予水凝胶 improved 透明度、自愈合行为以及抗反复形变能力。随着TA中儿茶酚/邻苯三酚基团的引入，该水凝胶在湿润条件下表现出强黏附性（在猪皮上可达289 kPa），并能黏附于多种基底。它还展现出显著的生物功能性，包括高效的活性氧清除能力（约92%）、高抗菌活性（>98%）以及低溶血率（0.77%）。此外，稳定的离子电导率和机械柔韧性使其可用作监测人体运动的应变传感器。总体而言，本研究为增强PLA基水凝胶的稳定性和功能性提供了一种可行策略，表明其在生物医学黏合剂和柔性电子器件中具有应用潜力。
Abstract
Poly(lipoic acid) (PLA) often suffers from poor stability in physiological environments and limited adhesion, which restricts its practical use. To address these issues, a multicomponent adhesive hydrogel was constructed by integrating sodium lipoate (LANa) and tannic acid (TA) into the system. LANa helps adjust the hydrophilicity of the network, while TA, with abundant phenolic groups, establishes extensive hydrogen-bonding interactions with the polydisulfide chains. These combined effects effectively inhibit disulfide bond cleavage and enhance the overall stability of the material. At the same time, the disruption of crystalline domains leads to a more amorphous structure, giving the hydrogel improved transparency, self-healing behavior, and resistance to repeated deformation. With the introduction of catechol/pyrogallol groups from TA, the hydrogel shows strong adhesion under wet conditions (up to 289 kPa on porcine skin) and can bond to a wide range of substrates. It also demonstrates notable biofunctionality, including efficient ROS scavenging (∼92%), high antibacterial activity (>98%), and low hemolysis (0.77%). In addition, the stable ionic conductivity and mechanical flexibility enable its use as a strain sensor for monitoring human motion. Overall, this study provides a feasible strategy for enhancing the stability and functionality of PLA-based hydrogels, suggesting their applicability in biomedical adhesives and flexible electronic devices.
如何引用
AMA
Ming Gao, Jiancheng Liu, Xiaoyang Li, Kunyan Sui, Weidong Gu. A Multifunctional Adhesive Hydrogel with Antibacterial and Antioxidant Properties for Biointerface Applications.. ACS applied bio materials. 2026; doi:10.1021/acsabm.6c00808.
APA
Ming Gao, Jiancheng Liu, Xiaoyang Li, Kunyan Sui, Weidong Gu (2026). A Multifunctional Adhesive Hydrogel with Antibacterial and Antioxidant Properties for Biointerface Applications.. ACS applied bio materials. https://doi.org/10.1021/acsabm.6c00808
GB/T 7714
Ming Gao, Jiancheng Liu, Xiaoyang Li, Kunyan Sui, Weidong Gu. A Multifunctional Adhesive Hydrogel with Antibacterial and Antioxidant Properties for Biointerface Applications.[J]. ACS applied bio materials, 2026 doi:10.1021/acsabm.6c00808.
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