遵循3R原则探索乙基纤维素-乙醇凝胶硬化疗法治疗血管畸形的特性与制备
Exploring the Properties and Preparation of Ethyl Cellulose-Ethanol Gel Sclerotherapy for the Treatment of Vascular Malformations following the 3R Principle.
摘要(中文译文)
血管畸形，包括动静脉畸形（AVMs）、静脉畸形（VMs）和淋巴管畸形（LMs），存在破裂、出血及显著致病风险。AVMs为高流量病变，与动静脉之间异常分流相关；而VMs和LMs为低流量畸形，以静脉或淋巴管扩张为特征。当前治疗选择有限，常导致心理健康问题及生活质量下降，尤其在年轻患者中。以乙醇为基础的硬化治疗是一种有效的微创治疗方法，尤其适用于低流量病变。含乙醇的可注射乙基纤维素基凝胶已成为硬化这些异常血管的潜在治疗手段；然而，其确切作用机制及在血管内的行为仍未被充分了解。全面了解其治疗机制对于优化临床应用和实现最佳治疗结果至关重要。本研究探索了乙醇基凝胶的生产工艺、稳定性及血管内行为，为临床实践和患者护理提供了重要信息。我们建立了一种注射模型，以阐明凝胶在体外流动条件下及卵内血管中的物理特性和动力学。结果表明，该注射方法有效且安全，不良反应有限。这些见解有助于推进可注射聚合物基凝胶制剂的研发，为治疗血管畸形提供改进的选择。
Abstract
Vascular malformations, including arteriovenous malformations (AVMs), venous malformations (VMs), and lymphatic malformations (LMs), carry a risk of rupture, bleeding, and significant morbidity. AVMs are high-flow lesions associated with abnormal shunting between arteries and veins, while VMs and LMs are low-flow malformations characterized by dilated venous or lymphatic channels. Current therapeutic options are limited, which often results in mental health issues and diminished quality of life, particularly in younger patients. Sclerotherapy with ethanol-based agents is an effective minimally invasive treatment, particularly for low-flow lesions. Injectable ethyl cellulose-based gels containing ethanol have emerged as a potential treatment for sclerosing these abnormal vessels; however, their exact mechanism of action and behavior within the vasculature remain inadequately understood. Comprehensive knowledge of the therapeutic mechanism is crucial for optimizing its clinical application and achieving the best treatment outcomes. In this study, we explored the production process, stability, and intravascular behavior of ethanol-based gels, providing essential information for clinical practice and patient care. We developed an injection model to elucidate the physical properties and dynamics of the gel under flow conditions in vitro and within blood vessels in ovo. Our results demonstrate an effective and safe injection, showing limited adverse effects. These insights contribute to advancing injectable polymer-based gel formulations, offering improved options for treating vascular malformations.
如何引用
AMA
David Schorr, Jens Schaefer, Marcus Bakowsky, Eduard Preis, Robert Mandic, Urban W Geisthoff, et al. Exploring the Properties and Preparation of Ethyl Cellulose-Ethanol Gel Sclerotherapy for the Treatment of Vascular Malformations following the 3R Principle.. ACS applied bio materials. 2026; doi:10.1021/acsabm.6c00523.
APA
David Schorr, Jens Schaefer, Marcus Bakowsky, Eduard Preis, Robert Mandic, Urban W Geisthoff, et al (2026). Exploring the Properties and Preparation of Ethyl Cellulose-Ethanol Gel Sclerotherapy for the Treatment of Vascular Malformations following the 3R Principle.. ACS applied bio materials. https://doi.org/10.1021/acsabm.6c00523
GB/T 7714
David Schorr, Jens Schaefer, Marcus Bakowsky, Eduard Preis, Robert Mandic, Urban W Geisthoff, et al. Exploring the Properties and Preparation of Ethyl Cellulose-Ethanol Gel Sclerotherapy for the Treatment of Vascular Malformations following the 3R Principle.[J]. ACS applied bio materials, 2026 doi:10.1021/acsabm.6c00523.
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