具有侧化胆碱能调节的爪转换
Paw switching with lateralized cholinergic modulation.
摘要(中文译文)
运动偏好（如利手）反映了脊椎动物大脑功能的不对称性。尽管这些手或爪偏好通常较为稳定，但可通过经验或训练加以重塑；然而，这种转换的神经基础尚不清楚。本研究表明，小鼠中由经验驱动的爪偏好转变源于两半球之间不对称的胆碱能调制。采用旨在诱导爪偏好转换的行为范式，我们发现一部分动物在训练后形成了稳定的偏好改变。选择性激活或抑制大脑一侧的胆碱能神经元足以影响这种转换行为。在偏侧化运动过程中，两半球之间出现内源性胆碱能活动失衡，提示半球间胆碱能不对称使运动灵活性得以实现。这些发现揭示了一种此前未被认识到的机制，即胆碱能信号动态调控偏侧化运动控制，为半球间失衡如何塑造持久的个体运动偏好提供了见解。
Abstract
Motor preferences, such as handedness, reflect asymmetries in brain function across vertebrates. Although generally stable, these hand or paw preferences can be reshaped through experience or training; however, the neural basis of such switching remains unclear. Here we show that experience-driven shifts in paw preference in mice arise from asymmetric cholinergic modulation between the two hemispheres. Using a behavioral paradigm designed to induce paw switching, we found that a subset of animals developed a stable change in preference following training. Selective activation or inhibition of cholinergic neurons on one side of the brain was sufficient to bias this switching behavior. During lateralized movements, an endogenous imbalance in cholinergic activity emerges between the hemispheres, suggesting that interhemispheric cholinergic asymmetry enables motor flexibility. These findings identify a previously unrecognized mechanism by which cholinergic signaling dynamically regulates lateralized motor control, providing insight into how hemispheric imbalances may shape persistent individual motor preferences.
如何引用
AMA
Kazuki Okamoto, Yasuhiro R Tanaka, Shigeki Kato, Shu Xie, Guochuan Li, Kazuto Kobayashi, et al. Paw switching with lateralized cholinergic modulation.. Cell reports. 2026; doi:10.1016/j.celrep.2026.117734.
APA
Kazuki Okamoto, Yasuhiro R Tanaka, Shigeki Kato, Shu Xie, Guochuan Li, Kazuto Kobayashi, et al (2026). Paw switching with lateralized cholinergic modulation.. Cell reports. https://doi.org/10.1016/j.celrep.2026.117734
GB/T 7714
Kazuki Okamoto, Yasuhiro R Tanaka, Shigeki Kato, Shu Xie, Guochuan Li, Kazuto Kobayashi, et al. Paw switching with lateralized cholinergic modulation.[J]. Cell reports, 2026 doi:10.1016/j.celrep.2026.117734.
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