胶质细胞释放的血清素驱动秀丽隐杆线虫的鼻触反应
Glia-released serotonin drives nose touch responses in Caenorhabditis elegans.
摘要(中文译文)
触觉对生存至关重要，它引导个体与环境的互动，并构成社会与情感联系的基础。虽然触觉感知由神经元和胶质细胞组成的机械感受器介导，但胶质细胞在机械感觉中的作用仍知之甚少。在此，我们发现了胶质细胞来源的血清素在秀丽隐杆线虫中调控触觉敏感性的一个此前未被认识的功能。利用活体钙和血清素成像、荧光显微镜以及行为学实验，我们证明头感器鞘（amphid sheath，AMsh）胶质细胞通过致密核心囊泡释放血清素。这种血清素激活神经元受体SER-5以使ASH神经元产生反应，同时作用于胶质细胞MOD-1自身受体以提供反馈控制。我们进一步鉴定了一种浓度依赖性机制，该机制通过cAMP依赖性和Ca依赖性通路精细调节感觉敏感性。结合此前关于胶质细胞释放GABA的证据，我们的发现确立了胶质细胞作为触觉主动调节者的地位，通过平衡兴奋与抑制来维持机械感觉功能。
Abstract
Touch is essential for survival, guiding interactions with the environment and forming the basis of social and emotional connection. While touch perception is mediated by mechanoreceptors composed of neurons and glia, the role of glia in mechanosensation remains poorly understood. Here, we uncover a previously unrecognized function for glia-derived serotonin in regulating touch sensitivity in Caenorhabditis elegans. Using in vivo Ca and serotonin imaging, fluorescence microscopy, and behavioral assays, we show that amphid sheath (AMsh) glia release serotonin via dense core vesicles. This serotonin activates the neuronal receptor SER-5 to enable ASH neuron responses, while simultaneously engaging glial MOD-1 autoreceptors to provide feedback control. We further identify a concentration-dependent mechanism that fine-tunes sensory sensitivity through cAMP- and Ca-dependent pathways. Together with prior evidence of glial GABA release, our findings establish glia as active regulators of touch, balancing excitation and inhibition to maintain mechanosensory function.
如何引用
AMA
David R Logan, Carlos D Oliva, Lei Wang, Melisa L Lamberti, Isabella L Gay, Olivia R White, et al. Glia-released serotonin drives nose touch responses in Caenorhabditis elegans.. Cell reports. 2026; doi:10.1016/j.celrep.2026.117553.
APA
David R Logan, Carlos D Oliva, Lei Wang, Melisa L Lamberti, Isabella L Gay, Olivia R White, et al (2026). Glia-released serotonin drives nose touch responses in Caenorhabditis elegans.. Cell reports. https://doi.org/10.1016/j.celrep.2026.117553
GB/T 7714
David R Logan, Carlos D Oliva, Lei Wang, Melisa L Lamberti, Isabella L Gay, Olivia R White, et al. Glia-released serotonin drives nose touch responses in Caenorhabditis elegans.[J]. Cell reports, 2026 doi:10.1016/j.celrep.2026.117553.
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