脓毒症中的肠道菌群失调：机制及以肺和脑相互作用为重点的肠-器官轴
Gut microbiota dysbiosis in sepsis: mechanisms and the gut-organ axis with a focus on lung and brain interactions.
摘要(中文译文)
脓毒症是由宿主对感染反应失调所致的危及生命的器官功能障碍，其高死亡率与复杂的病理生理过程密切相关。近年来，肠道菌群作为人体最大的微生态系统，在脓毒症的发生、发展及预后中的关键作用日益受到关注。本叙述性综述总结了近期研究进展，重点聚焦于过去3年发表的文献，同时纳入部分早期研究以提供必要的机制背景。文章首先深入探讨脓毒症诱导肠道菌群失衡的病理生理机制，重点阐述肠道屏障破坏、免疫-菌群相互作用紊乱及微生物代谢产物改变等关键因素。随后，综述全面评估了以肠道菌群调控为中心的临床诊断生物标志物潜力及治疗策略，包括益生菌、益生元、粪菌移植及针对微生物代谢产物的靶向干预。最后，讨论了当前研究面临的挑战及未来转化方向，旨在为脓毒症的精准防治提供新的理论基础和策略启示。然而，大多数靶向菌群的治疗策略仍处于临床前或早期临床阶段，其在脓毒症中的有效性和安全性尚需进一步验证。
Abstract
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, with its high mortality closely linked to complex pathophysiological processes. In recent years, the gut microbiota, as the largest human micro-ecosystem, has garnered increasing attention for its critical role in the onset, progression, and prognosis of sepsis. This narrative review summarizes recent research advances, with a particular focus on studies published over the past 3 years, while incorporating selected earlier studies to provide essential mechanistic background. It first delves into the pathophysiological mechanisms underlying sepsis-induced gut microbiota imbalance, highlighting key factors such as intestinal barrier disruption, immune-microbiota interaction disturbances, and alterations in microbial metabolites. Subsequently, the review comprehensively evaluates clinical diagnostic biomarker potentials and therapeutic strategies centered on gut microbiota modulation, including probiotics, prebiotics, fecal microbiota transplantation, and targeted interventions on microbial metabolites. Finally, current research challenges and future translational directions are discussed, aiming to provide novel theoretical foundations and strategic insights for precise prevention and treatment of sepsis. However, most microbiota-targeted therapeutic strategies remain at the preclinical or early clinical stage, and their efficacy and safety in sepsis require further validation.
如何引用
AMA
Rui Liu, Junlong Wang. Gut microbiota dysbiosis in sepsis: mechanisms and the gut-organ axis with a focus on lung and brain interactions.. Frontiers in microbiology. 2026; doi:10.3389/fmicb.2026.1797486.
APA
Rui Liu, Junlong Wang (2026). Gut microbiota dysbiosis in sepsis: mechanisms and the gut-organ axis with a focus on lung and brain interactions.. Frontiers in microbiology. https://doi.org/10.3389/fmicb.2026.1797486
GB/T 7714
Rui Liu, Junlong Wang. Gut microbiota dysbiosis in sepsis: mechanisms and the gut-organ axis with a focus on lung and brain interactions.[J]. Frontiers in microbiology, 2026 doi:10.3389/fmicb.2026.1797486.
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