当骨骼使主动脉变形时：青少年骨质疏松症继发的长期血管重塑
When Bone Deforms the Aorta: Long-Term Vascular Remodeling Secondary to Juvenile Osteoporosis.
摘要(中文译文)
妊娠期及青少年相关骨质疏松症是一种罕见疾病，可能导致病理性骨折及终生严重的椎体畸形。本文报告一例84岁女性患者，既往有骨质疏松症病史，于首次妊娠期间经双能X线吸收测定法（DXA）确诊。在超过六十年的时间里，她发生了T12、L1和L3椎体的多次骨质疏松性椎体压缩性骨折，导致进行性脊柱后侧凸和显著的身高丢失。在慢性阻塞性肺疾病的常规随访期间，呼吸科申请进行的计算机断层扫描显示，继发于 underlying 脊柱畸形的胸腹主动脉明显延长和偏移。鉴于上述发现，患者被转诊至血管科进行进一步评估。本病例突出了长期肌肉骨骼畸形与血管解剖结构之间一种罕见描述的相互作用，尤其涉及主动脉等大血管的移位和重塑。这些发现强调了横断面成像和多学科方法在评估涉及多系统的复杂慢性疾病中的重要性。
Abstract
Pregnancy- and juvenile-associated osteoporosis is a rare condition that may lead to pathological fractures and severe vertebral deformities throughout life. We present the case of an 84-year-old female with a history of osteoporosis, diagnosed by dual-energy X-ray absorptiometry (DXA) during her first pregnancy. Over a period of more than six decades, she sustained multiple osteoporotic vertebral compression fractures of the T12, L1, and L3 vertebral bodies, leading to progressive kyphoscoliosis and significant loss of height. During routine follow-up for chronic obstructive pulmonary disease, a computed tomography scan requested by the Pulmonology Department revealed marked elongation and deviation of the thoracoabdominal aorta secondary to the underlying spinal deformity. Given these findings, the patient was referred to the Angiology Department for further evaluation. This case highlights a rarely described interaction between long-standing musculoskeletal deformities and vascular anatomy, particularly involving displacement and remodeling of major vessels such as the aorta. These findings emphasize the importance of cross-sectional imaging and a multidisciplinary approach in the assessment of complex chronic conditions with multisystem involvement.
如何引用
AMA
José Miguel Zermeño, Deneisy H Trinidad Cruz, Gloria Jimena Coello, Diana V Jimenez Peña, Eva Brittania Delgado. When Bone Deforms the Aorta: Long-Term Vascular Remodeling Secondary to Juvenile Osteoporosis.. Cureus. 2026; doi:10.7759/cureus.110979.
APA
José Miguel Zermeño, Deneisy H Trinidad Cruz, Gloria Jimena Coello, Diana V Jimenez Peña, Eva Brittania Delgado (2026). When Bone Deforms the Aorta: Long-Term Vascular Remodeling Secondary to Juvenile Osteoporosis.. Cureus. https://doi.org/10.7759/cureus.110979
GB/T 7714
José Miguel Zermeño, Deneisy H Trinidad Cruz, Gloria Jimena Coello, Diana V Jimenez Peña, Eva Brittania Delgado. When Bone Deforms the Aorta: Long-Term Vascular Remodeling Secondary to Juvenile Osteoporosis.[J]. Cureus, 2026 doi:10.7759/cureus.110979.
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