老年人的营养不良、虚弱和高跌倒风险：在一项横断面研究中检查它们的相互作用
Malnutrition, Frailty, and High Fall Risk in Older Adults: Examining Their Interactive Effects in a Cross-Sectional Study.
摘要(中文译文)
跌倒已成为老年人重要的公共卫生问题，对健康造成显著影响。衰弱和营养不良是备受关注且与跌倒风险密切相关的变量。尽管这些因素与跌倒风险的独立关联已被认识，但其联合效应及定量关系仍知之甚少。本研究旨在探讨营养不良与衰弱对老年人跌倒风险的交互作用。本研究招募了来自10个社区的13，970名老年人，采用衰弱评分、微型营养评估量表及STEADI工具进行评估。通过logistic回归计算乘法交互作用，采用相对超额危险度（RERI）、归因比（AP）和协同指数（SI）评估加法交互作用。24.1%的参与者被判定为高跌倒风险。衰弱和营养不良各自独立与跌倒风险相关。与非衰弱且营养良好的参与者相比，衰弱与营养不良共存者的高跌倒风险比值显著升高（OR = 15.83，95% CI：11.77-21.28）。衰弱与营养不良之间存在显著的乘法交互作用（OR = 1.064，95% CI：1.047-1.082）。同时发现显著的阳性加法交互作用：RERI = 1.58（95% CI：0.19-2.96），AP = 0.10（95% CI：0.01-0.19），SI = 1.18（95% CI：1.02-1.36）。衰弱与营养不良与老年人高跌倒风险相关，两者之间存在适度的阳性交互作用，为制定综合性跌倒预防与管理策略提供了实证依据。
Abstract
Falls are a major public health concern for older adults, impacting health. Frailty and malnutrition are widely studied variables closely linked to fall risk. While the individual links of these factors with fall risk are known, their combined effects and quantitative relationships remain poorly understood. This study aimed to explore the interactive effects of malnutrition and frailty on fall risk among older adults. This study involved the recruitment of 13,970 older adults from 10 communities, who were assessed using the frailty score, the Mini-Nutritional Assessment Scale, and the STEADI tool. Multiplicative interactions were calculated through logistic regression. Additive interactions were evaluated using the relative excess risk (RERI), attribution ratio (AP), and synergy index (SI). 24.1% of participants were identified as having high fall risk. Frailty and malnutrition each independently correlate with fall risk. Compared with participants who were non-frail and well-nourished, those with coexisting frailty and malnutrition had significantly higher odds of high fall risk (OR = 15.83, 95% CI: 11.77-21.28). A significant multiplicative interaction between frailty and malnutrition was confirmed (OR = 1.064, 95% CI: 1.047-1.082). Significant positive additive interaction was also identified: RERI = 1.58 (95% CI: 0.19-2.96), AP = 0.10 (95% CI: 0.01-0.19), and SI = 1.18 (95% CI: 1.02-1.36). Frailty and malnutrition are correlated with high fall risk in older adults, with a modest positive interaction observed between the two conditions, offering empirical support for the development of comprehensive fall prevention and management strategies.
如何引用
AMA
Honghong Wen, Heting Liang, Qingyun Mao, Shaoting Yang, Xiaoli Yuan. Malnutrition, Frailty, and High Fall Risk in Older Adults: Examining Their Interactive Effects in a Cross-Sectional Study.. Clinical interventions in aging. 2026; doi:10.2147/CIA.S609884.
APA
Honghong Wen, Heting Liang, Qingyun Mao, Shaoting Yang, Xiaoli Yuan (2026). Malnutrition, Frailty, and High Fall Risk in Older Adults: Examining Their Interactive Effects in a Cross-Sectional Study.. Clinical interventions in aging. https://doi.org/10.2147/CIA.S609884
GB/T 7714
Honghong Wen, Heting Liang, Qingyun Mao, Shaoting Yang, Xiaoli Yuan. Malnutrition, Frailty, and High Fall Risk in Older Adults: Examining Their Interactive Effects in a Cross-Sectional Study.[J]. Clinical interventions in aging, 2026 doi:10.2147/CIA.S609884.
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