类器官技术在垂体神经内分泌肿瘤研究中的发展和应用
Development and application of organoid technology in pituitary neuroendocrine tumor research.
摘要(中文译文)
本文综述了类器官技术的发展及其在垂体神经内分泌肿瘤研究中的最新进展。作为三维体外培养模型，类器官能够再现原生器官的结构和功能特征，为研究垂体神经内分泌肿瘤的疾病机制、开展药物筛选和制定个性化治疗策略提供了创新平台。文章首先概述了类器官技术的历史演进，随后重点阐述其在垂体神经内分泌肿瘤研究中的具体应用，包括疾病建模、药物检测以及再生医学中的潜在用途。最后，文章探讨了该领域当前面临的挑战，并展望了未来的研究方向和潜在的临床应用前景。
Abstract
This review examines the development of organoid technology and its recent advances in the study of pituitary neuroendocrine tumors. As three-dimensional in vitro culture models, organoids can recapitulate the structural and functional characteristics of native organs, providing an innovative platform for investigating disease mechanisms, conducting drug screening, and developing personalized treatment strategies for pituitary neuroendocrine tumors. The article begins with an overview of the historical progression of organoid technology and then focuses on its specific applications in pituitary neuroendocrine tumor research, including disease modeling, drug testing, and potential uses in regenerative medicine. Finally, it addresses current challenges in the field and outlines future research directions and potential clinical applications.
如何引用
AMA
Qing Rao, Jun Shen, Zeyu Lin, Zhang Xiong, Xiaochun Jiang, Yonghong Zhu, et al. Development and application of organoid technology in pituitary neuroendocrine tumor research.. The Journal of international medical research. 2026; doi:10.1177/03000605261467834.
APA
Qing Rao, Jun Shen, Zeyu Lin, Zhang Xiong, Xiaochun Jiang, Yonghong Zhu, et al (2026). Development and application of organoid technology in pituitary neuroendocrine tumor research.. The Journal of international medical research. https://doi.org/10.1177/03000605261467834
GB/T 7714
Qing Rao, Jun Shen, Zeyu Lin, Zhang Xiong, Xiaochun Jiang, Yonghong Zhu, et al. Development and application of organoid technology in pituitary neuroendocrine tumor research.[J]. The Journal of international medical research, 2026 doi:10.1177/03000605261467834.
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