高总胆固醇与高密度脂蛋白胆固醇比值与高血压患者高尿酸血症之间的关联：乌干达中部的一项横断面研究
Association between a high total cholesterol-to-high-density lipoprotein cholesterol ratio and hyperuricemia among patients with hypertension: A cross-sectional study from central Uganda.
摘要(中文译文)
背景：高尿酸血症是高血压患者中的一种心血管代谢危险因素。总胆固醇与高密度脂蛋白胆固醇比值升高反映致动脉粥样硬化性血脂失衡和胰岛素抵抗。本研究探讨了乌干达心脏研究所高血压患者中总胆固醇与高密度脂蛋白胆固醇高比值与高尿酸血症之间的关联。方法：我们在乌干达心脏研究所开展了一项横断面研究，于2025年8月4日至2025年10月20日连续招募了277例年龄≥18岁的高血压患者。高尿酸血症定义为男性血清尿酸水平≥7 mg/dL、女性≥6 mg/dL，而总胆固醇与高密度脂蛋白胆固醇高比值定义为≥5。结果：在277例参与者中，89例患有高尿酸血症，比例为32.1%（95%置信区间：26.9-37.9）。总胆固醇与高密度脂蛋白胆固醇比值≥5的参与者中高尿酸血症的发生率（53.8%）显著高于比值<5者（25.5%）（p < 0.001）。调整混杂因素后，总胆固醇与高密度脂蛋白胆固醇高比值仍与高尿酸血症独立相关（调整后比值比 = 2.83，95%置信区间：1.31-6.09，p = 0.008）。总胆固醇与高密度脂蛋白胆固醇比值对高尿酸血症表现出中等预测能力，最佳截断值为4.33（敏感性58%；特异性71%），曲线下面积为0.68（95%置信区间：0.61-0.75）。结论：高尿酸血症在高血压患者中较为普遍。总胆固醇与高密度脂蛋白胆固醇高比值是该人群高尿酸血症的潜在预测指标。
Abstract
BackgroundHyperuricemia is a cardiometabolic risk factor among patients with hypertension. A high total cholesterol-to-high-density lipoprotein cholesterol ratio reflects atherogenic lipid imbalance and insulin resistance. This study investigated the association between a high total cholesterol-to-high-density lipoprotein cholesterol ratio and hyperuricemia among patients with hypertension at Uganda Heart Institute.MethodsWe conducted a cross-sectional study among 277 consecutively recruited patients with hypertension aged ≥18 years from 4 August 2025 to 20 October 2025 at Uganda Heart Institute. Hyperuricemia was defined as a serum uric acid level of ≥7 mg/dL in men and ≥6 mg/dL in women, whereas a high total cholesterol-to-high-density lipoprotein cholesterol ratio was defined as ≥5.ResultsAmong 277 participants, 89 had hyperuricemia, giving a proportion of 32.1% (95% confidence interval: 26.9-37.9). Hyperuricemia was significantly more common in participants with a total cholesterol-to-high-density lipoprotein cholesterol ratio of ≥5 (53.8%) than in those with a ratio of <5 (25.5%) (p < 0.001). After adjustment for confounders, a high total cholesterol-to-high-density lipoprotein cholesterol ratio remained independently associated with hyperuricemia (adjusted odds ratio = 2.83, 95% confidence interval: 1.31-6.09, p = 0.008). The total cholesterol-to-high-density lipoprotein cholesterol ratio demonstrated moderate predictive ability for hyperuricemia, with an optimal cutoff value of 4.33 (sensitivity, 58%; specificity, 71%) and an area under the curve of 0.68 (95% confidence interval: 0.61-0.75).ConclusionHyperuricemia is prevalent among patients with hypertension. A high total cholesterol-to-high-density lipoprotein cholesterol ratio is a potential predictor of hyperuricemia in this population.
如何引用
AMA
Blendar Ainebyoona, James Emorut, Samuel Emuru, Simon Nuwatuha, Joe Omara, Carol Nantongo, et al. Association between a high total cholesterol-to-high-density lipoprotein cholesterol ratio and hyperuricemia among patients with hypertension: A cross-sectional study from central Uganda.. The Journal of international medical research. 2026; doi:10.1177/03000605261462032.
APA
Blendar Ainebyoona, James Emorut, Samuel Emuru, Simon Nuwatuha, Joe Omara, Carol Nantongo, et al (2026). Association between a high total cholesterol-to-high-density lipoprotein cholesterol ratio and hyperuricemia among patients with hypertension: A cross-sectional study from central Uganda.. The Journal of international medical research. https://doi.org/10.1177/03000605261462032
GB/T 7714
Blendar Ainebyoona, James Emorut, Samuel Emuru, Simon Nuwatuha, Joe Omara, Carol Nantongo, et al. Association between a high total cholesterol-to-high-density lipoprotein cholesterol ratio and hyperuricemia among patients with hypertension: A cross-sectional study from central Uganda.[J]. The Journal of international medical research, 2026 doi:10.1177/03000605261462032.
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