成人肥胖和2型糖尿病表型的hs-CRP/HDL比值：一项横断面研究
hs-CRP/HDL Ratio Across Obesity and Type 2 Diabetes Mellitus Phenotypes in Adults: A Cross-Sectional Study.
摘要(中文译文)
慢性低度炎症和脂质代谢在肥胖及2型糖尿病（T2DM）的发生发展中发挥重要作用。高敏C反应蛋白与高密度脂蛋白胆固醇比值（hs-CRP/HDL-C）整合了上述通路，已被提出作为一种新型代谢风险生物标志物。然而，关于其与肥胖及T2DM关联的证据仍然有限。本回顾性横断面研究纳入413名成人的数据，包括251例T2DM患者和162例非T2DM个体。肥胖状态依据BMI分类单独评估。将hs-CRP/HDL-C比值按四分位数分组，以最低四分位数作为参照组。采用多因素logistic回归和限制性立方样条分析评估其与肥胖及T2DM的关联。通过亚组分析评估这些关联在不同人群亚组中的一致性。结果显示，hs-CRP/HDL-C比值与T2DM患病率呈显著正相关。与最低四分位数个体相比，hs-CRP/HDL-C比值较高四分位数个体的T2DM患病风险显著升高。在完全校正模型中，hs-CRP/HDL-C比值每增加一个单位，T2DM风险升高（OR = 1.59，95% CI：1.14-2.20，P = 0.006），而与肥胖的关联在完全校正后减弱并失去统计学显著性。限制性立方样条分析证实hs-CRP/HDL-C比值与T2DM风险之间存在显著的总体关联（P-总体 = 0.034）。尽管hs-CRP/HDL-C比值在粗模型中与肥胖相关（OR = 1.40，95% CI：1.05-1.70，P = 0.019），但校正后该关联不显著（OR = 1.18，95% CI：0.90-1.56，P = 0.229）。在本研究中，hs-CRP/HDL-C比值升高与T2DM患病率显著相关，可能代表一种与代谢性炎症相关的标志物，尤其在糖代谢紊乱个体中。
Abstract
Chronic low-grade inflammation and lipid metabolism play an important role in the development of obesity and type 2 diabetes mellitus (T2DM). The ratio of high-sensitivity C-reactive protein to high-density lipoprotein cholesterol (hs-CRP/HDL-C) integrates these pathways and it has been proposed as a novel biomarker of metabolic risk. However, evidence regarding its association with obesity and T2DM remains limited. This retrospective cross-sectional study included data from 413 adults, comprising 251 individuals with T2DM and 162 individuals without T2DM. Obesity status was assessed separately according to BMI categories. The hs-CRP/HDL-C ratio was divided into quartiles, with the lowest quartile used as the reference category. Its associations with obesity and T2DM were evaluated using multivariable logistic regression and restricted cubic spline analysis. Subgroup analyses were conducted to evaluate the consistency of these associations across different population subgroups. A significantly positive association was noted between the hs-CRP/HDL-C ratio and the presence of T2DM. Compared with individuals in the lowest quartile, those in the higher quartiles of the hs-CRP/HDL-C ratio had significantly higher odds of T2DM. In the fully adjusted model, each unit increase in the hs-CRP/HDL-C ratio was associated with higher odds of T2DM (OR = 1.59, 95% CI: 1.14-2.20, = 0.006), whereas the association with obesity was attenuated and lost statistical significance after full adjustment. RCS analysis confirmed a significant overall association between the hs-CRP/HDL-C ratio and T2DM risk (-overall = 0.034). Although the hs-CRP/HDL-C ratio was associated with obesity in the crude model (OR = 1.40, 95% CI: 1.05-1.70, = 0.019), the association was not significant after adjustment (OR = 1.18, 95% CI: 0.90-1.56, = 0.229). In our study, an elevated hs-CRP/HDL-C ratio was significantly associated with the presence of T2DM and may represent a marker associated with metabolic inflammation, particularly in individuals with glycometabolic disorders.
如何引用
AMA
Crina Cristina Solomon, Nastaca Alina Palade, Felicia Gabriela Gligor, Alina Liliana Pintea, Claudiu Morgovan, Adina Frum, et al. hs-CRP/HDL Ratio Across Obesity and Type 2 Diabetes Mellitus Phenotypes in Adults: A Cross-Sectional Study.. Diagnostics (Basel, Switzerland). 2026; doi:10.3390/diagnostics16132013.
APA
Crina Cristina Solomon, Nastaca Alina Palade, Felicia Gabriela Gligor, Alina Liliana Pintea, Claudiu Morgovan, Adina Frum, et al (2026). hs-CRP/HDL Ratio Across Obesity and Type 2 Diabetes Mellitus Phenotypes in Adults: A Cross-Sectional Study.. Diagnostics (Basel, Switzerland). https://doi.org/10.3390/diagnostics16132013
GB/T 7714
Crina Cristina Solomon, Nastaca Alina Palade, Felicia Gabriela Gligor, Alina Liliana Pintea, Claudiu Morgovan, Adina Frum, et al. hs-CRP/HDL Ratio Across Obesity and Type 2 Diabetes Mellitus Phenotypes in Adults: A Cross-Sectional Study.[J]. Diagnostics (Basel, Switzerland), 2026 doi:10.3390/diagnostics16132013.
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