富氢果冻减轻了喂食SAMP8小鼠的高脂肪/高糖饮食中的脂肪组织炎症和代谢功能障碍
Hydrogen-rich jelly attenuates adipose tissue inflammation and metabolic dysfunction in high-fat/high-sucrose diet-fed SAMP8 mice.
摘要(中文译文)
分子氢已被报道具有抗氧化和抗炎作用；然而，其在衰老相关代谢应激下对炎症和肠道菌群的影响仍不清楚。本研究在喂食高脂/高蔗糖饮食（HFHSD）的衰老加速小鼠倾向-8（SAMP8）小鼠中，研究了富氢果冻（HRJ）的作用。HFHSD喂养诱导了脂肪组织炎症、代谢紊乱以及肠道菌群组成的改变。HRJ处理抑制了巨噬细胞向脂肪组织的浸润，降低了炎性细胞因子水平，并恢复了脂联素水平。HRJ还部分改善了葡萄糖耐量和代谢参数。肠道菌群分析显示，基于β多样性分析，HFHSD与微生物群落结构的差异相关，而HRJ处理与特定细菌分类群及预测微生物功能的探索性变化相关，尽管这些变化在FDR校正后未保持显著。这些发现表明，分子氢主要通过抑制脂肪炎症来减轻HFHSD诱导的代谢紊乱。尽管观察到肠道微生物组成的探索性变化，但其生物学意义仍不清楚，需要进一步研究。
Abstract
Molecular hydrogen has been reported to exert antioxidant and anti-inflammatory effects; however, its impact on inflammation and gut microbiota under aging-associated metabolic stress remains unclear. In this study, we investigated the effects of hydrogen-rich jelly (HRJ) in senescence-accelerated mouse prone-8 (SAMP8) mice fed a high-fat/high-sucrose diet (HFHSD). HFHSD feeding induced adipose tissue inflammation, metabolic disturbances, and alterations in gut microbiota composition. Treatment with HRJ suppressed macrophage infiltration into adipose tissue, reduced inflammatory cytokine levels, and restored adiponectin levels. HRJ also partially improved glucose tolerance and metabolic parameters. Gut microbiota analysis revealed that HFHSD was associated with differences in microbial community structure based on beta diversity analysis, whereas HRJ treatment was associated with exploratory changes in specific bacterial taxa and predicted microbial functions, although these changes did not remain significant after FDR correction. These findings suggest that molecular hydrogen attenuates HFHSD-induced metabolic disturbances primarily through suppression of adipose inflammation. Although exploratory changes in gut microbial composition were observed, their biological significance remains unclear and requires further investigation.
如何引用
AMA
Sayaka Takahashi, Keiichi Nakagawa, Tooru Takeda, Toshiaki Ishizuka. Hydrogen-rich jelly attenuates adipose tissue inflammation and metabolic dysfunction in high-fat/high-sucrose diet-fed SAMP8 mice.. Biochemical and biophysical research communications. 2026; doi:10.1016/j.bbrc.2026.154243.
APA
Sayaka Takahashi, Keiichi Nakagawa, Tooru Takeda, Toshiaki Ishizuka (2026). Hydrogen-rich jelly attenuates adipose tissue inflammation and metabolic dysfunction in high-fat/high-sucrose diet-fed SAMP8 mice.. Biochemical and biophysical research communications. https://doi.org/10.1016/j.bbrc.2026.154243
GB/T 7714
Sayaka Takahashi, Keiichi Nakagawa, Tooru Takeda, Toshiaki Ishizuka. Hydrogen-rich jelly attenuates adipose tissue inflammation and metabolic dysfunction in high-fat/high-sucrose diet-fed SAMP8 mice.[J]. Biochemical and biophysical research communications, 2026 doi:10.1016/j.bbrc.2026.154243.
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