植物来源的分子作为慢性疾病中NF-κB、PI3K/Akt、MAPK和AMPK/mTOR信号传导的多靶点调节剂
Plant-derived molecules as multitarget modulators of NF-κB, PI3K/Akt, MAPK, and AMPK/mTOR signaling in chronic diseases.
摘要(中文译文)
细胞信号通路调控包括炎症、氧化应激、增殖、凋亡、代谢和免疫稳态在内的基本细胞过程。NF-κB、MAPK、PI3K/Akt、Nrf2/ARE、JAK/STAT、AMPK/mTOR和Wnt/β-catenin等相互关联通路的失调，在癌症、糖尿病、心血管疾病、神经退行性疾病和炎症性疾病等慢性疾病中起重要作用。越来越多的证据表明，植物来源的植物化学物作为多靶点调节剂，能够通过同时调控多个分子网络来恢复信号平衡。本综述对植物化学物介导的慢性疾病相关主要信号通路调控进行了更新和整合性概述，强调机制性交叉对话和转化相关性。采用PubMed、SciFinder和Google Scholar进行了全面的文献调查，以收集植物化学物调控信号通路的实验和临床证据。姜黄素、白藜芦醇、槲皮素、小檗碱、表没食子儿茶素没食子酸酯、芹菜素和人参皂苷等主要植物化学物可抑制NF-κB、PI3K/Akt、MAPK和JAK/STAT信号传导，同时激活Nrf2介导的抗氧化防御、AMPK信号传导、自噬和凋亡。这些化合物还调控代谢性炎症、神经炎症、线粒体功能障碍和癌症相关信号网络。与以往聚焦于孤立通路或单个化合物的综述不同，本综述整合了多种慢性疾病中的信号交叉对话和多靶点植物化学物作用。尽管具有有前景的治疗潜力，但由于生物利用度差、药代动力学变异性、缺乏标准化以及大规模临床验证不足，临床转化仍然受限。
Abstract
Cell signaling pathways regulate essential cellular processes including inflammation, oxidative stress, proliferation, apoptosis, metabolism, and immune homeostasis. Dysregulation of interconnected pathways such as NF-κB, MAPK, PI3K/Akt, Nrf2/ARE, JAK/STAT, AMPK/mTOR, and Wnt/β-catenin contributes significantly to chronic diseases including cancer, diabetes, cardiovascular disorders, neurodegenerative diseases, and inflammatory conditions. Increasing evidence indicates that plant-derived phytochemicals act as multitarget modulators capable of restoring signaling balance through simultaneous regulation of multiple molecular networks. This review provides an updated and integrative overview of phytochemical-mediated modulation of major signaling pathways involved in chronic diseases, emphasizing mechanistic cross-talk and translational relevance. A comprehensive literature survey was conducted using PubMed, SciFinder, and Google Scholar to collect experimental and clinical evidence on phytochemical regulation of signaling pathways. Major phytochemicals including curcumin, resveratrol, quercetin, berberine, epigallocatechin gallate, apigenin, and ginsenosides suppress NF-κB, PI3K/Akt, MAPK, and JAK/STAT signaling while activating Nrf2-mediated antioxidant defense, AMPK signaling, autophagy, and apoptosis. These compounds also regulate metabolic inflammation, neuroinflammation, mitochondrial dysfunction, and cancer-associated signaling networks. Unlike previous reviews focused on isolated pathways or individual compounds, this review integrates signaling cross-talk and multitarget phytochemical actions across diverse chronic diseases. Despite promising therapeutic potential, clinical translation remains limited by poor bioavailability, pharmacokinetic variability, lack of standardization, and insufficient large-scale clinical validation.
如何引用
AMA
Kaushik Modak, Arup Dey, Krishna Kumar Bharti, Manish Kumar Gautam, Sandip Mondal, Partha Pratim Dutta, et al. Plant-derived molecules as multitarget modulators of NF-κB, PI3K/Akt, MAPK, and AMPK/mTOR signaling in chronic diseases.. Biochemical and biophysical research communications. 2026; doi:10.1016/j.bbrc.2026.154097.
APA
Kaushik Modak, Arup Dey, Krishna Kumar Bharti, Manish Kumar Gautam, Sandip Mondal, Partha Pratim Dutta, et al (2026). Plant-derived molecules as multitarget modulators of NF-κB, PI3K/Akt, MAPK, and AMPK/mTOR signaling in chronic diseases.. Biochemical and biophysical research communications. https://doi.org/10.1016/j.bbrc.2026.154097
GB/T 7714
Kaushik Modak, Arup Dey, Krishna Kumar Bharti, Manish Kumar Gautam, Sandip Mondal, Partha Pratim Dutta, et al. Plant-derived molecules as multitarget modulators of NF-κB, PI3K/Akt, MAPK, and AMPK/mTOR signaling in chronic diseases.[J]. Biochemical and biophysical research communications, 2026 doi:10.1016/j.bbrc.2026.154097.
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