延胡索（Corydalis yanhusuo W. T. Wang）干燥块茎的传统应用、化学成分、药理作用、质量控制及临床应用
Traditional application, Chemical composition, Pharmacological effects, Quality control and Clinical application of Corydalis yanhusuo W. T. Wang dried Rhizome.
摘要(中文译文)
在中国，延胡索（Corydalis yanhusuo W.T. Wang）被列为重要的民族药，具有活血止痛的功效。由于其显著的镇痛和抗炎药理特性，其在世界范围内被广泛用于疼痛治疗和中药复方中。其临床疗效确切，药理活性明确，在我国多民族医学实践中应用广泛。系统阐明了延胡索传统应用、化学成分、药理作用及质量控制的研究进展，为延胡索的进一步开发利用、质量提升和产业化发展提供了坚实的科学支撑。本研究全面查阅了《中华本草》《中国民族药辞典》等经典著作，并以“延胡索”“传统研究”“化学成分”“药理作用”“质量控制”等关键词检索了PubMed、Web of Science、CNKI和万方数据库，系统总结了延胡索在民族药记载、物质基础、作用机制及质量控制等方面的研究进展，为延胡索的深入开发和临床应用提供科学依据。四氢帕马丁（tetrahydropalmatine）、脱氢紫堇碱（dehydrocorydaline）等生物碱是核心活性成分，是其发挥镇痛、抗炎和镇静作用的物质基础。传统上用于治疗气滞血瘀所致疼痛证候。现代研究证实其具有多靶点、多通路调控的特点，醋制可显著增强其镇痛作用。质量控制多以高效液相色谱为主要技术手段。现有证据支持延胡索为一种具有显著镇痛潜力的民族药。未来研究应优先开展针对痛经和心绞痛的疾病特异性验证；对关键通路（包括PI3K/Akt-eNOS/NO、MAPK-NF-κB-iNOS、NLRP3-IL-1β、cAMP/cGMP及SUCNR1信号通路）进行机制确证；并建立整合DNA标记、多成分指纹图谱、质量标志物（Q-marker）和生物活性测定的质量控制体系，以阐明化学变异与疗效之间的关系。
Abstract
In China, Corydalis yanhusuo W.T. Wang is listed as an important ethnic medicine for promoting blood circulation and relieving pain. Because of its significant analgesic and anti-inflammatory pharmacological properties, it is widely used in pain treatment and traditional Chinese medicine compound in the world. Its clinical efficacy is definite, pharmacological activity is clear, and it is widely used in multi-ethnic medical practice in China. The research progress of traditional application, chemical composition, pharmacological effect and quality control of CY were systematically elucidated, which provided solid scientific support for further development and utilization, quality improvement and industrialization development of CY. This study comprehensively reviewed classical texts such as "Chinese Materia Medica" and "China Ethnic Medicine Dictionary", and searched PubMed, Web of Science, CNKI, and Wanfang databases using keywords including "Yanhusuo", "traditional research", "chemical constituents", "pharmacological effects", and "quality control". It systematically summarized the research progress on its ethnic medicine records, material basis, mechanism of action, and quality control, providing a scientific basis for the in-depth development and clinical application of Yanhusuo. Alkaloids such as tetrahydropalmatine and dehydrocorydaline are the core active components, which are the material basis for their analgesic, anti-inflammatory and sedative effects. Traditionally, it is used to treat pain syndromes of qi stagnation and blood stasis. Modern research has confirmed that it has the characteristics of multi-target and multi-pathway regulation, and vinegar processing can significantly enhance its analgesic effect. Quality control is mostly based on high performance liquid chromatography as the main technical means. Current evidence supports CY as an ethnomedicinal herb with notable analgesic potential. Future studies should prioritize disease-specific validation in dysmenorrhea and angina pectoris; mechanistic confirmation of key pathways, including PI3K/Akt-eNOS/NO, MAPK-NF-κB-iNOS, NLRP3-IL-1β, cAMP/cGMP, and SUCNR1 signaling; and an integrated quality-control system using DNA markers, multi-component fingerprints, Q-markers, and bioactivity assays to clarify the relationship between chemical variation and therapeutic efficacy.
如何引用
AMA
Zhengyang Yu, Jinyi Wu, Xing Yang, Ningyu Cheng, Jia Tian, Jinsong Su, et al. Traditional application, Chemical composition, Pharmacological effects, Quality control and Clinical application of Corydalis yanhusuo W. T. Wang dried Rhizome.. Journal of ethnopharmacology. 2027; doi:10.1016/j.jep.2026.122156.
APA
Zhengyang Yu, Jinyi Wu, Xing Yang, Ningyu Cheng, Jia Tian, Jinsong Su, et al (2027). Traditional application, Chemical composition, Pharmacological effects, Quality control and Clinical application of Corydalis yanhusuo W. T. Wang dried Rhizome.. Journal of ethnopharmacology. https://doi.org/10.1016/j.jep.2026.122156
GB/T 7714
Zhengyang Yu, Jinyi Wu, Xing Yang, Ningyu Cheng, Jia Tian, Jinsong Su, et al. Traditional application, Chemical composition, Pharmacological effects, Quality control and Clinical application of Corydalis yanhusuo W. T. Wang dried Rhizome.[J]. Journal of ethnopharmacology, 2027 doi:10.1016/j.jep.2026.122156.
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