中国男性酒精依赖患者在语言流畅性任务中的额颞皮质活动：一项功能性近红外光谱研究
Frontotemporal cortical activity in Chinese male alcohol-dependent patients during a verbal fluency task: a functional near-infrared spectroscopy study.
摘要(中文译文)
酒精依赖与前额叶皮层功能的改变有关；然而，既往使用词语流畅性任务的功能性近红外光谱研究结果并不一致。本研究考察了中国男性酒精依赖患者与健康对照者在任务相关皮层激活方面的差异。31名右利手男性酒精依赖住院患者和31名健康男性对照者完成了一项普通话词语流畅性任务。使用52通道功能性近红外光谱系统测量任务相关的氧合血红蛋白浓度变化。采用独立样本t检验比较两组间各通道的Δβ值，并进行了多重比较校正。两组在年龄或受教育年限上无显著差异。与健康对照者相比，酒精依赖患者在通道23表现出更强的氧合血红蛋白激活，该通道主要覆盖右侧背外侧前额叶皮层，并与右侧额下回部分重叠（t = 3.315，FDR校正q = 0.104）。其他通道未观察到显著的组间差异。右侧背外侧前额叶皮层和右侧额下回激活增强可能反映了神经资源的代偿性募集，或认知控制与情绪调节系统参与程度的增加。功能性近红外光谱可能是评估酒精依赖患者皮层功能的有用工具，但仍需更大规模、包含不同性别及跨语言的研究来验证这些发现。
Abstract
Alcohol dependence is associated with alterations in prefrontal cortical function; however, previous functional near-infrared spectroscopy studies using verbal fluency tasks have produced inconsistent findings. This study examined differences in task-related cortical activation between Chinese male patients with alcohol dependence and healthy controls. Thirty-one right-handed male inpatients with alcohol dependence and 31 healthy male controls completed a Mandarin verbal fluency task. A 52-channel functional near-infrared spectroscopy system was used to measure task-related changes in oxygenated hemoglobin concentrations. Channel-wise Δβ values were compared between the groups using independentsamples t-tests with correction for multiple comparisons. The groups did not differ significantly in age or years of education. Compared with healthy controls, patients with alcohol dependence exhibited greater oxygenated hemoglobin activation in channel 23, which primarily covered the right dorsolateral prefrontal cortex and partially overlapped with the right inferior frontal gyrus (t = 3.315, FDR-adjusted q = 0.104). No significant between-group differences were observed in the other channels. Increased activation in the right dorsolateral prefrontal cortex and right inferior frontal gyrus may reflect compensatory recruitment of neural resources or increased engagement of cognitive-control and emotion-regulation systems. Functional near-infrared spectroscopy may be a useful tool for assessing cortical function in alcohol dependence, although larger, mixed-sex, and cross-linguistic studies are required to validate these findings.
如何引用
AMA
Suilin Jia, Jie Liu, Jiaqi Zheng, Meizhi Zheng, Lijun Wang, Wei Jin, et al. Frontotemporal cortical activity in Chinese male alcohol-dependent patients during a verbal fluency task: a functional near-infrared spectroscopy study.. Frontiers in psychiatry. 2026; doi:10.3389/fpsyt.2026.1827350.
APA
Suilin Jia, Jie Liu, Jiaqi Zheng, Meizhi Zheng, Lijun Wang, Wei Jin, et al (2026). Frontotemporal cortical activity in Chinese male alcohol-dependent patients during a verbal fluency task: a functional near-infrared spectroscopy study.. Frontiers in psychiatry. https://doi.org/10.3389/fpsyt.2026.1827350
GB/T 7714
Suilin Jia, Jie Liu, Jiaqi Zheng, Meizhi Zheng, Lijun Wang, Wei Jin, et al. Frontotemporal cortical activity in Chinese male alcohol-dependent patients during a verbal fluency task: a functional near-infrared spectroscopy study.[J]. Frontiers in psychiatry, 2026 doi:10.3389/fpsyt.2026.1827350.
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