【肠脑轴与帕金森病：肠脑相互作用的研究进展】

摘要(中文译文)

帕金森病（PD）是一种以运动功能障碍为特征的进行性神经退行性疾病。其主要病理表现为黑质神经元中α-突触核蛋白（α-Syn）的异常积聚以及多巴胺能神经元（DAn）的丢失。胃肠道（GI）症状是PD常见的非运动症状之一。已知大脑与肠道通过副交感神经和肠神经系统（ENS）进行交流，形成称为肠-脑轴的双向通路。肠道菌群失调可能是PD起源和病理进展的关键驱动因素，在病理性α-Syn向中枢神经系统（CNS）传播中发挥重要作用，从而促进PD的进展。本文综述了肠道菌群失调在PD发病和进展中的作用机制，包括其对肠道屏障完整性、神经炎症及病理性α-Syn传播的影响，并讨论了针对肠-脑轴的诊断和治疗策略，包括菌群移植、迷走神经刺激、Toll样受体4（TLR4）拮抗剂、运动训练等，为PD的诊断和治疗提供新的思路。

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by motor dysfunction. The main pathological manifestations are abnormal accumulation of α-synuclein (α-Syn) in substantia nigra neurons and loss of dopaminergic neurons (DAn). Gastrointestinal (GI) symptom is one of the common non-motor symptoms in PD. It is known that the brain and gut communicate via the parasympathetic nerves and the enteric nervous system (ENS), forming a bidirectional pathway called the gut-brain axis. Dysbiosis of the gut microbiota may be a key driver in the origin and pathological progression of PD, playing an important role in the spread of pathological α-Syn to the central nervous system (CNS) and thereby promoting the progression of PD. This article reviews the mechanism of gut microbiota dysbiosis in the pathogenesis and progression of PD, including its effects on intestinal barrier integrity, neuroinflammation, and pathological α-Syn transmission, and discusses the diagnosis and therapeutic strategies targeting the gut-brain axis, including microbiota transplantation, vagus nerve stimulation, Toll-like receptor 4 (TLR4) antagonists, exercise training, ., providing new insights for the diagnosis and treatment of PD.

如何引用

Sheng li xue bao : [Acta physiologica Sinica] 的其他文献

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