[非编码RNA介导的PI3K/AKT/mTOR信号通路调节参与三阴性乳腺癌症发病和进展的最新进展]
[Recent advances in non-coding RNA-mediated PI3K/AKT/mTOR signaling pathway regulation involved in triple-negative breast cancer pathogenesis and progression].
摘要(中文译文)
三阴性乳腺癌（TNBC）具有高侵袭、高转移、预后差和高死亡率的特点，是乳腺癌中最具侵袭性的形式。目前，TNBC仍缺乏有效的治疗靶点。磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（AKT）/哺乳动物雷帕霉素靶蛋白（mTOR）通路的异常激活在TNBC中普遍存在，导致化疗药物耐药性增加和预后不良。非编码RNA（ncRNA），包括微小RNA（miRNA）、长链非编码RNA（lncRNA）和环状RNA（circRNA），参与多种生物学过程，可作为癌基因或抑癌基因调控PI3K/AKT/mTOR通路，从而促进或抑制TNBC的发生发展。本文综述了一些重要的miRNA、lncRNA、circRNA及其在TNBC中调控PI3K/AKT/mTOR通路的靶点和分子机制，以期开辟TNBC研究的新途径，最终推动TNBC精准有效治疗的发展。
Abstract
Triple-negative breast cancer (TNBC) is characterized by high invasion and metastasis, poor prognosis, and high mortality, making it the most aggressive form of breast cancer. Currently, there is still a lack of effective therapeutic targets for TNBC. Aberrant activation of phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway is prevalent in TNBC, leading to increased resistance to chemotherapeutic agents and poor prognosis. Non-coding RNA (ncRNA), including microRNA (miRNA), long non-coding RNA (lncRNA) and circular RNA (circRNA), are involved in a variety of biological processes and can be used as oncogenes or tumor suppressor genes to regulate the PI3K/AKT/mTOR pathway to promote or inhibit the occurrence and development of TNBC. This article reviews some important miRNA, lncRNA, circRNA, and their targets and molecular mechanisms that regulate the PI3K/AKT/mTOR pathway in TNBC, hoping to open up new avenues for the research of TNBC and ultimately promote the development of precise and effective treatments for TNBC.
如何引用
AMA
Zhu Huang, Wen-Jing Li, Zi-Juan Song, Si-Yi Huang, Zi-Qing Yang, Ya-Ya Chu, et al. [Recent advances in non-coding RNA-mediated PI3K/AKT/mTOR signaling pathway regulation involved in triple-negative breast cancer pathogenesis and progression].. Sheng li xue bao : [Acta physiologica Sinica]. 2026; doi:10.13294/j.aps.2025.0109.
APA
Zhu Huang, Wen-Jing Li, Zi-Juan Song, Si-Yi Huang, Zi-Qing Yang, Ya-Ya Chu, et al (2026). [Recent advances in non-coding RNA-mediated PI3K/AKT/mTOR signaling pathway regulation involved in triple-negative breast cancer pathogenesis and progression].. Sheng li xue bao : [Acta physiologica Sinica]. https://doi.org/10.13294/j.aps.2025.0109
GB/T 7714
Zhu Huang, Wen-Jing Li, Zi-Juan Song, Si-Yi Huang, Zi-Qing Yang, Ya-Ya Chu, et al. [Recent advances in non-coding RNA-mediated PI3K/AKT/mTOR signaling pathway regulation involved in triple-negative breast cancer pathogenesis and progression].[J]. Sheng li xue bao : [Acta physiologica Sinica], 2026 doi:10.13294/j.aps.2025.0109.
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