碳纳米管-蛋白质-纤维素导电复合水凝胶：通过光热疗法体内治疗糖尿病伤口并通过光声成像跟踪实时伤口评估
Conductive Hybrid Hydrogel of Carbon Nanotubes-Protein-Cellulose: In Vivo Treatment of Diabetic Wound via Photothermal Therapy and Tracking Real-Time Wound Assessment via Photoacoustic Imaging.
摘要(中文译文)
糖尿病创面因愈合缓慢且易感染，给医疗保健带来了重大挑战，并导致严重并发症。在本研究中，我们开发了一种基于碳纳米管的导电蛋白-纤维素水凝胶，旨在通过光热疗法促进创面愈合。该水凝胶的独特性质，包括高导电性和生物相容性，已在体外通过细胞活力、溶血和组织学评估进行了评价。在糖尿病大鼠体内研究中显示，该水凝胶显著改善了创面愈合，创面闭合速率更快。免疫组织化学分析观察到炎症标志物明显减少和血管形成增强，支持了上述结果。此外，光声成像提供了血流和组织氧水平的实时数据，显示出愈合过程中的积极趋势。总体而言，这些发现表明这种导电水凝胶，尤其是与光热疗法联合应用时，有望成为糖尿病创面的有效治疗方法，为创面护理策略提供了有前景的可能性。
Abstract
Diabetic wounds pose significant challenges in healthcare due to their slow healing rates and susceptibility to infections, leading to severe complications. In this study, we developed a carbon nanotube-based conductive protein-cellulose hydrogel designed to enhance wound healing through photothermal therapy. The hydrogel's unique properties, including high electrical conductivity and biocompatibility, were assessed in vitro for cell viability, hemolysis, and histological evaluations. In vivo studies on diabetic rats revealed that the hydrogel significantly improved wound healing, with faster wound closure rates. These results were supported by noticeable reductions in inflammatory markers and enhanced blood vessel formation, as observed through immunohistochemical analysis. Additionally, photoacoustic imaging offered real-time data on blood flow and tissue oxygen levels, showing positive trends in the healing process. Overall, these findings point to the potential of this conductive hydrogel, especially when paired with photothermal therapy, to serve as an effective treatment for diabetic wounds, offering promising possibilities in wound care strategies.
如何引用
AMA
Kaustubh Naik, Shikha Tripathi, Rahul Ranjan, Somesh Agrawal, Shweta Singh, Prodyut Dhar, et al. Conductive Hybrid Hydrogel of Carbon Nanotubes-Protein-Cellulose: In Vivo Treatment of Diabetic Wound via Photothermal Therapy and Tracking Real-Time Wound Assessment via Photoacoustic Imaging.. ACS applied bio materials. 2025; doi:10.1021/acsabm.4c01755.
APA
Kaustubh Naik, Shikha Tripathi, Rahul Ranjan, Somesh Agrawal, Shweta Singh, Prodyut Dhar, et al (2025). Conductive Hybrid Hydrogel of Carbon Nanotubes-Protein-Cellulose: In Vivo Treatment of Diabetic Wound via Photothermal Therapy and Tracking Real-Time Wound Assessment via Photoacoustic Imaging.. ACS applied bio materials. https://doi.org/10.1021/acsabm.4c01755
GB/T 7714
Kaustubh Naik, Shikha Tripathi, Rahul Ranjan, Somesh Agrawal, Shweta Singh, Prodyut Dhar, et al. Conductive Hybrid Hydrogel of Carbon Nanotubes-Protein-Cellulose: In Vivo Treatment of Diabetic Wound via Photothermal Therapy and Tracking Real-Time Wound Assessment via Photoacoustic Imaging.[J]. ACS applied bio materials, 2025 doi:10.1021/acsabm.4c01755.
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