具有与心丝虫相关呼吸道疾病相容的临床和血清学特征的猫的计算机断层扫描衍生支气管壁指数
Computed Tomography-Derived Bronchial Wall Indices in Cats with Clinical and Serological Features Compatible with Heartworm-Associated Respiratory Disease.
摘要(中文译文)
心虫相关呼吸系统疾病（HARD）是猫心丝虫病的早期表现，由未成熟虫体到达肺部并诱发明显的炎症性气道病变所致。本研究利用支气管壁与支气管比值（BW/B）及支气管壁与肺动脉比值（BW/A），对具有符合HARD的临床和血清学特征的猫进行CT衍生的支气管壁重塑定量分析。研究前瞻性纳入27只客户所有的猫：19只具有下气道临床症状且抗体血清阳性、被认为符合HARD的猫，以及8只因非心肺适应症接受CT检查的无症状血清阴性猫。所有猫均在标准化麻醉方案下接受胸部CT检查。于前部和后部肺区测量支气管腔直径、支气管总直径及肺动脉直径，并计算支气管壁厚度以得出BW/B和BW/A。符合HARD的猫在所有评估肺叶中均显示支气管壁厚度显著增加，BW/B和BW/A比值升高，支持弥漫性支气管重塑。BW/A是唯一显示显著区域与组别交互作用的指标，提示患病猫支气管壁重塑可能存在区域性分布模式。测量的重复性和再现性总体较高。CT衍生的支气管壁指标，尤其是BW/A，或可为描述具有符合HARD临床和血清学特征的猫的气道受累提供客观的补充工具。由于抗体血清阳性提示暴露而非确诊的活动性感染，且对照组样本量小、缺乏呼吸系统疾病对照、缺少组织病理学验证，这些发现应视为初步性和描述性结果。
Abstract
Heartworm-Associated Respiratory Disease (HARD) is an early manifestation of feline dirofilariosis caused by immature stages reaching the lungs and inducing marked inflammatory airway lesions. This study quantified computed tomography (CT)-derived bronchial wall remodeling in cats with clinical and serological features compatible with HARD using the bronchial wall-to-bronchus (BW/B) and bronchial wall-to-pulmonary artery (BW/A) ratios. Twenty-seven client-owned cats were prospectively included: 19 cats with lower-airway clinical signs and antibody seropositivity, considered compatible with HARD, and 8 asymptomatic seronegative cats that underwent CT for non-cardiorespiratory clinical indications. All underwent thoracic CT under a standardized anesthetic protocol. Bronchial lumen diameter, total bronchial diameter, and pulmonary artery diameter were measured in cranial and caudal lung regions, and bronchial wall thickness was calculated to derive BW/B and BW/A. Cats compatible with HARD showed significantly increased bronchial wall thickness and higher BW/B and BW/A ratios across all evaluated lung lobes, supporting diffuse bronchial remodeling. BW/A was the only index showing a significant area-by-group interaction, suggesting a possible regional distribution pattern of bronchial wall remodeling in affected cats. Measurement repeatability and reproducibility were high overall. CT-derived bronchial wall indices, particularly BW/A, may provide an objective complementary tool for characterizing airway involvement in cats with clinical and serological profiles compatible with HARD. Because antibody seropositivity indicates exposure rather than confirmed active infection, and because of the small control group, absence of respiratory disease comparators, and lack of histopathological validation, these findings should be considered preliminary and descriptive.
如何引用
AMA
Sara Nieves García-Rodríguez, Jorge Isidoro Matos, J Alberto Montoya-Alonso, Laín García-Guasch, Eva Mohr-Peraza, Elena Carretón. Computed Tomography-Derived Bronchial Wall Indices in Cats with Clinical and Serological Features Compatible with Heartworm-Associated Respiratory Disease.. Animals : an open access journal from MDPI. 2026; doi:10.3390/ani16111586.
APA
Sara Nieves García-Rodríguez, Jorge Isidoro Matos, J Alberto Montoya-Alonso, Laín García-Guasch, Eva Mohr-Peraza, Elena Carretón (2026). Computed Tomography-Derived Bronchial Wall Indices in Cats with Clinical and Serological Features Compatible with Heartworm-Associated Respiratory Disease.. Animals : an open access journal from MDPI. https://doi.org/10.3390/ani16111586
GB/T 7714
Sara Nieves García-Rodríguez, Jorge Isidoro Matos, J Alberto Montoya-Alonso, Laín García-Guasch, Eva Mohr-Peraza, Elena Carretón. Computed Tomography-Derived Bronchial Wall Indices in Cats with Clinical and Serological Features Compatible with Heartworm-Associated Respiratory Disease.[J]. Animals : an open access journal from MDPI, 2026 doi:10.3390/ani16111586.
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