产前非甾体抗炎药暴露与儿童肾病：系统综述和荟萃分析
Prenatal NSAIDs exposure and childhood kidney disease: a systematic review and meta-analysis.
摘要(中文译文)
研究表明，产前非甾体抗炎药（NSAIDs）暴露与儿童肾脏疾病之间存在关联；然而，尚缺乏共识。因此，我们开展了一项荟萃分析，以评估母亲产前NSAIDs暴露及其与儿童肾脏疾病风险的关系。我们系统检索了PubMed、Cochrane Library、Embase和Web of Science，并辅以手动检索参考文献，以筛选相关观察性研究纳入分析。数据提取和质量评价由两名研究者独立完成。采用随机效应荟萃分析估计合并比值比（OR）及相应的95%置信区间（CI）。共纳入7项研究，包含4，159，617名参与者。分析表明，产前NSAIDs暴露与儿童肾脏疾病风险之间存在关联（OR 1.36 [1.14-1.62]）。经校正分析（OR 2.40 [1.84-3.13]）和未校正分析（OR 1.10 [1.05-1.15]）后，妊娠期使用NSAIDs与儿童肾脏疾病风险相关。妊娠中晚期使用NSAIDs与儿童肾脏疾病风险相关（妊娠中期OR 1.17 [1.09-1.26]，妊娠晚期OR 1.10 [1.09-1.11]）。敏感性分析支持上述发现。通过本荟萃分析，我们为产前NSAIDs暴露与儿童肾脏疾病之间的关联提供了证据，但未能解决有关其他危险因素潜在混杂的因果推断问题。尚需更多高质量研究以确定与NSAIDs的关联是否具有因果性。
Abstract
Studies have shown a link between prenatal NSAIDs exposure and childhood kidney disease; however, consensus is lacking. Therefore, we conducted a meta-analysis to assess maternal prenatal exposure to NSAIDs and its relationship with the kidney disease risk in children. A systematic search of PubMed, Cochrane Library, Embase, and Web of Science was performed, supplemented by a manual search of references, to identify relevant observational studies for our analysis. Data extraction and quality assessment were independently conducted by two investigators. A random effects meta-analysis was conducted to estimate the summary odds ratio (ORs) and the corresponding 95% confidence interval (CIs). Seven studies including 4,159,617 participants were selected. The analysis indicated that there was an association between prenatal NSAIDs exposure and kidney disease risk in children (OR 1.36 [1.14-1.62]). After adjusted (OR 2.40 [1.84-3.13]) and unadjusted (OR 1.10 [1.05-1.15]) analyses, the use of NSAIDs during pregnancy was associated with the kidney disease risk in children. Use of NSAIDs in the second and third trimesters of pregnancy is associated with the kidney disease risk in children (second-trimester OR 1.17 [1.09-1.26] and third-trimester OR 1.10 [1.09-1.11]). Sensitivity analysis supported these findings. With our meta-analysis, we provide evidence for an association between prenatal NSAIDs exposure and kidney diseases in children but do not solve the causality issues concerning potential confounding by other risk factors. More high-quality studies are needed to establish whether the association with NSAIDs is causal.
如何引用
AMA
Xinping Cui, Rong Feng, Bin Song, Qian Zhou, Yan Zeng. Prenatal NSAIDs exposure and childhood kidney disease: a systematic review and meta-analysis.. Frontiers in pediatrics. 2026; doi:10.3389/fped.2026.1808919.
APA
Xinping Cui, Rong Feng, Bin Song, Qian Zhou, Yan Zeng (2026). Prenatal NSAIDs exposure and childhood kidney disease: a systematic review and meta-analysis.. Frontiers in pediatrics. https://doi.org/10.3389/fped.2026.1808919
GB/T 7714
Xinping Cui, Rong Feng, Bin Song, Qian Zhou, Yan Zeng. Prenatal NSAIDs exposure and childhood kidney disease: a systematic review and meta-analysis.[J]. Frontiers in pediatrics, 2026 doi:10.3389/fped.2026.1808919.
在 PubMed增强版 阅读全文
翻译全文 · AI 文献问答 · PDF 原文下载 · 引用导出