儿童肛周脓肿的年龄分层管理：整合“发育愈合轴”的拟议框架
Age-stratified management of pediatric perianal abscesses: a proposed framework integrating the "Developmental Healing Axis".
摘要(中文译文)
儿童肛周脓肿是一种常见但尚未被充分认识的疾病，由于组织脆弱及年龄相关的愈合动力学差异，其诊断和治疗面临挑战。本综述综合了当前关于儿童肛周脓肿的流行病学、病理生理学及管理方面的证据，为临床决策提供概念性基础。手术干预如切开引流可迅速缓解症状，但可能增加瘘管形成的风险，尤其是在年长儿童中。相比之下，包括抗生素治疗和观察在内的保守策略在婴幼儿中通常有效，反映了其较强的再生能力。免疫反应、微生物群组成及腺体解剖结构方面的年龄相关差异导致了疾病进展和愈合结局的不同。通过整合近期研究和临床指南的数据，本综述强调了个体化、年龄特异性管理对优化康复、减少复发及预防瘘管形成的重要性。此外，本综述指出了当前证据的不足，并强调需要标准化治疗方案以及未来对影响疾病病程的预测因素和微生物组相关因素进行研究。
Abstract
Pediatric perianal abscesses represent a frequent yet underrecognized condition that poses diagnostic and therapeutic challenges due to tissue fragility and age-dependent healing dynamics. This review synthesizes current evidence on the epidemiology, pathophysiology, and management of pediatric perianal abscesses to provide a conceptual basis for clinical decision-making. Surgical interventions such as incision and drainage offer rapid symptom relief but may increase the risk of fistula formation, particularly in older children. In contrast, conservative strategies including antibiotic therapy and observation are often effective in infants and young children, reflecting their superior regenerative capacity. Age-related differences in immune response, microbiota composition, and glandular anatomy contribute to variations in disease progression and healing outcomes. By integrating data from recent studies and clinical guidelines, this review highlights the importance of individualized, age-specific management to optimize recovery, minimize recurrence, and prevent fistula development. Furthermore, it identifies gaps in current evidence and underscores the need for standardized treatment protocols and future research into predictive and microbiome-related factors influencing disease course.
如何引用
AMA
He-Xue Yuan, Zhi-Tao Yin, Li-Hua Wang, Lin Ma, Yang Liu, Yu-Lin Ju, et al. Age-stratified management of pediatric perianal abscesses: a proposed framework integrating the "Developmental Healing Axis".. Frontiers in pediatrics. 2026; doi:10.3389/fped.2026.1789225.
APA
He-Xue Yuan, Zhi-Tao Yin, Li-Hua Wang, Lin Ma, Yang Liu, Yu-Lin Ju, et al (2026). Age-stratified management of pediatric perianal abscesses: a proposed framework integrating the "Developmental Healing Axis".. Frontiers in pediatrics. https://doi.org/10.3389/fped.2026.1789225
GB/T 7714
He-Xue Yuan, Zhi-Tao Yin, Li-Hua Wang, Lin Ma, Yang Liu, Yu-Lin Ju, et al. Age-stratified management of pediatric perianal abscesses: a proposed framework integrating the "Developmental Healing Axis".[J]. Frontiers in pediatrics, 2026 doi:10.3389/fped.2026.1789225.
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