{"_":"Age and hypoalbuminemia independently predict pulmonary consolidation in children with 23S rRNA A2063G-mutant pneumonia: a retrospective single-center study.","i":["Mycoplasma pneumoniae"]}
肺炎支原体肺炎（MPP）伴23S rRNA A2063G突变的患儿易出现进行性肺实变。本研究旨在探讨此类患儿肺实变的临床特征及独立危险因素。对2023年1月至2024年12月期间某三级甲等综合医院收治的MPP患儿临床资料进行回顾性单中心分析。依据靶向下一代测序（tNGS）结果，将患儿分为A2063G突变阳性组和阴性组。突变阳性患儿进一步分为肺实变亚组和非实变亚组。采用多因素logistic回归分析识别A2063G突变阳性MPP患儿肺实变的独立危险因素。共纳入347例患儿。与无A2063G突变的患儿相比，携带该突变的患儿年龄较大，入院前咳嗽及肺实变发生率较高，球蛋白（GLB）、中性粒细胞与淋巴细胞比值（NLR）、单核细胞与淋巴细胞比值（MLR）、血小板与淋巴细胞比值（PLR）、泛免疫炎症值（PIV）及系统性免疫炎症指数（SII）水平升高；同时，其淋巴细胞（LYM）和白蛋白（ALB）水平显著降低（均< 0.05）。在携带A2063G突变的患儿中，合并肺实变者较未合并肺实变者发热持续时间更长、最高体温更高、住院时间更长、重症肺炎发生率更高、C反应蛋白与淋巴细胞比值（CLR）更高，但双肺炎症发生率、ALB及尿酸（UA）水平更低（均< 0.05）。多因素logistic回归分析确定年龄和ALB为A2063G突变阳性MPP患儿肺实变的独立危险因素（OR = 1.010和0.875，均< 0.05）。年龄较大和ALB水平较低与A2063G突变MPP患儿肺实变风险较高相关，提示宿主炎症免疫反应增强促进了肺实变的发生。
pneumonia (MPP) with 23S rRNA A2063G mutation is prone to progressive pulmonary consolidation. This study aimed to explore the clinical characteristics and independent risk factors of pulmonary consolidation among such children. A retrospective, single-center analysis was conducted on the clinical data of children with MPP admitted to a Grade A tertiary general hospital between January 2023 and December 2024. Based on targeted next-generation sequencing (tNGS), children were divided into A2063G mutation-positive and -negative groups. Mutation-positive children were further classified into pulmonary consolidation and non-consolidation subgroups. Multivariate logistic regression was used to identify independent risk factors for pulmonary consolidation in A2063G mutation-positive MPP children. A total of 347 children were included in the study. Compared with children without the A2063G mutation, children with the mutation presented older age, higher rates of pre-admission cough and pulmonary consolidation, as well as elevated globulin (GLB), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), pan-immune-inflammation value (PIV) and systemic immune-inflammation index (SII) levels; meanwhile, their lymphocytes (LYM) and albumin (ALB) levels were significantly lower (all < 0.05). Within children with the A2063G mutation, those with pulmonary consolidation had higher duration of fever, maximum body temperature, length of hospital stay, severe pneumonia rate, and C-reactive protein-to-lymphocyte ratio (CLR), but lower rate of bilateral lung inflammation, ALB, and uric acid (UA) than those without pulmonary consolidation (all < 0.05). Multivariate logistic regression analysis identified age and ALB as independent risk factors for pulmonary consolidation in A2063G mutation-positive MPP children (OR = 1.010 and 0.875, respectively; both < 0.05). Older age and lower ALB levels are associated with a higher risk of pulmonary consolidation in children with A2063G-mutant MPP, suggesting that an enhanced host inflammatory immune response contributes to the development of pulmonary consolidation.
Haiwen Guo, Xin Zhang, Lirong Luo. {"_":"Age and hypoalbuminemia independently predict pulmonary consolidation in children with 23S rRNA A2063G-mutant pneumonia: a retrospective single-center study.","i":["Mycoplasma pneumoniae"]}. Frontiers in pediatrics. 2026; doi:10.3389/fped.2026.1773231.
Haiwen Guo, Xin Zhang, Lirong Luo (2026). {"_":"Age and hypoalbuminemia independently predict pulmonary consolidation in children with 23S rRNA A2063G-mutant pneumonia: a retrospective single-center study.","i":["Mycoplasma pneumoniae"]}. Frontiers in pediatrics. https://doi.org/10.3389/fped.2026.1773231
Haiwen Guo, Xin Zhang, Lirong Luo. {"_":"Age and hypoalbuminemia independently predict pulmonary consolidation in children with 23S rRNA A2063G-mutant pneumonia: a retrospective single-center study.","i":["Mycoplasma pneumoniae"]}[J]. Frontiers in pediatrics, 2026 doi:10.3389/fped.2026.1773231.
翻译全文 · AI 文献问答 · PDF 原文下载 · 引用导出