在电极上跳舞：用于日常糖尿病肾病管理的可穿戴连续多路监测
Dancing on Electrodes: Wearable Continuous Multiplexed Monitoring for Daily Diabetic Nephropathy Management.
摘要(中文译文)
糖尿病肾病已成为严重的公共卫生问题，然而现有的连续葡萄糖监测设备无法为糖尿病肾病患者提供全面的洞察。在此，我们开发了一种连续多重监测（CMM）系统，用于同时监测三种关键生物标志物：pH、葡萄糖（Glu）和尿酸（UA）。我们提出了“W-C-W”电极复用策略：沉积聚苯胺（PANI）纳米纤维构建pH传感器（“W”模式），然后将该电极重新用作Glu和UA传感器的对电极（“C”模式）。该策略使Glu和UA传感器能够进行约五次pH校准。传感器表现出优异的传感性能（pH、Glu和UA传感器的灵敏度分别为69.7 mV/pH、5.71 nA/mM和163 nA/mM）以及优异的体外和体内生物相容性。我们在SD大鼠中验证了系统的pH自校准功能以及对Glu和UA的长期监测能力。结果表明，检测误差降低，且与商用临床设备高度相关，表明其在糖尿病肾病患者日常健康管理中具有显著的应用潜力。
Abstract
Diabetic nephropathy has become a serious public health issue, yet current continuous glucose monitoring devices fail to provide comprehensive insights for DN patients. Here, we develop a continuous multiplexed monitoring (CMM) system for the simultaneous monitoring of three key biomarkers: pH, glucose (Glu), and uric acid (UA). We propose the "W-C-W" electrode multiplexing strategy: depositing polyaniline (PANI) nanofiber to construct a pH sensor ("W" mode), then reusing this electrode as the counter electrode for Glu and UA sensors ("C" mode). This strategy enables approximately five pH calibration times for Glu and UA sensors. The sensors exhibit excellent sensing performance (sensitivities of the pH, Glu, and UA sensors are 69.7 mV/pH, 5.71 nA/mM, and 163 nA/mM, respectively) and excellent in vitro and in vivo biocompatibility. We validated the system's pH self-calibration function and long-term monitoring for Glu and UA in SD rats. The results showed the detection error decreased and a high correlation with the commercial clinical-use devices, indicating significant potential for application in daily health management for DN patients.
如何引用
AMA
Zhiqi Li, Zijie Li, Yongmei Chen, Zhengkun Liu, Chenfei Liu, Yuying Lin, et al. Dancing on Electrodes: Wearable Continuous Multiplexed Monitoring for Daily Diabetic Nephropathy Management.. ACS nano. 2026; doi:10.1021/acsnano.6c04744.
APA
Zhiqi Li, Zijie Li, Yongmei Chen, Zhengkun Liu, Chenfei Liu, Yuying Lin, et al (2026). Dancing on Electrodes: Wearable Continuous Multiplexed Monitoring for Daily Diabetic Nephropathy Management.. ACS nano. https://doi.org/10.1021/acsnano.6c04744
GB/T 7714
Zhiqi Li, Zijie Li, Yongmei Chen, Zhengkun Liu, Chenfei Liu, Yuying Lin, et al. Dancing on Electrodes: Wearable Continuous Multiplexed Monitoring for Daily Diabetic Nephropathy Management.[J]. ACS nano, 2026 doi:10.1021/acsnano.6c04744.
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