免疫活性水凝胶工程补充了胶质母细胞瘤治疗的肿瘤治疗领域
Engineering of Immunoactive Hydrogels Complements Tumor-Treating Fields for Glioblastoma Therapy.
摘要(中文译文)
多形性胶质母细胞瘤（GBM）作为最常见的原发性恶性脑肿瘤，手术切除后几乎普遍复发。肿瘤治疗电场（TTF）是一种有前景且已用于临床的GBM治疗方法，越来越多的证据表明其可能激发抗肿瘤免疫。在此，我们通过单细胞RNA测序分辨率揭示了TTF在GBM中经由鞘脂代谢相关通路介导的内质网应激所触发的免疫原性细胞死亡（ICD）。进一步，我们设计了一种ATP响应性水凝胶佐剂（Ha），与TTF协同实现抗原和CpG的时空可控释放，重新激活髓系细胞相互作用网络并增强持续性抗肿瘤反应。Ha补充的TTF疗法（HaTTF）能有效抑制GBM荷瘤大鼠的肿瘤生长，优于仅能延缓进展的TTF疗法。本研究建立了一个整合TTF的佐剂增强型杀瘤免疫平台，具有应用于多种恶性实体瘤的潜力。
Abstract
Glioblastoma multiforme (GBM) as the most prevalent primary malignant brain tumor shows nearly universal recurrence following surgical resection. Tumor-treating fields (TTF), a promising and clinical therapy for GBM, may trigger antitumor immunity, as suggested by growing evidence. Herein, we uncover the TTF-triggered immunogenic cell death (ICD) at single-cell RNA sequencing resolution in GBM through sphingolipid-metabolism-associated pathway-mediated endoplasmic reticulum stress. Further, an ATP-responsive hydrogel adjuvant (Ha) was designed to synergize with TTF for spatiotemporally controlled release of antigens and CpG, reactivating myeloid cell interaction networks and augmenting sustained antitumor responses. The Ha-complemented TTF therapy (HaTTF) could effectively suppress tumor growth in GBM-bearing rats, outperforming TTF therapy, which merely delayed progression. This study establishes an adjuvant-enhanced tumoricidal immunity platform integrating TTF, with potential applications across various malignant solid tumors.
如何引用
AMA
Yingzhao Shao, Dongchen Li, Zide Wang, Xin Yang, Zehan Shang, Jinming Han, et al. Engineering of Immunoactive Hydrogels Complements Tumor-Treating Fields for Glioblastoma Therapy.. ACS nano. 2026; doi:10.1021/acsnano.6c00361.
APA
Yingzhao Shao, Dongchen Li, Zide Wang, Xin Yang, Zehan Shang, Jinming Han, et al (2026). Engineering of Immunoactive Hydrogels Complements Tumor-Treating Fields for Glioblastoma Therapy.. ACS nano. https://doi.org/10.1021/acsnano.6c00361
GB/T 7714
Yingzhao Shao, Dongchen Li, Zide Wang, Xin Yang, Zehan Shang, Jinming Han, et al. Engineering of Immunoactive Hydrogels Complements Tumor-Treating Fields for Glioblastoma Therapy.[J]. ACS nano, 2026 doi:10.1021/acsnano.6c00361.
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