不同致动脉粥样硬化和胰岛素抵抗指数与多囊卵巢综合征患者不孕之间的关联
Association between different atherogenic and insulin resistance indices and infertility in polycystic ovary syndrome patients.
摘要(中文译文)
本研究旨在评估多种致动脉粥样硬化及胰岛素抵抗指标——包括TyG、TyG-BMI、AIP、TG-HDL和METS-IR——与多囊卵巢综合征（PCOS）女性不孕症之间的关联，并评价其临床实用性。在这项横断面研究中，我们分析了669名年龄在18至45岁之间、性活跃、在伊朗一家三级中心接受治疗的PCOS女性的数据（2021—2023年）。我们将PCOS不孕女性（≥12个月未成功受孕，n=274）与PCOS已生育女性（n=395）进行了比较。采用逻辑回归、限制性立方样条和受试者工作特征（ROC）分析来评估关联及预测效能。不孕女性在所有指标上均表现出显著更差的代谢特征（P<0.001）。AIP的关联点估计值最大（校正OR=9.065，95%CI：1.722-47.721）。TG-HDL呈现显著的非线性关系，其OR值在比值升至约2.5之前急剧上升。预测能力中等，AUC范围为0.598（TyG-BMI）至0.625（AIP、TG-HDL）。多种代谢指标，尤其是AIP，与PCOS女性不孕症相关，但其单独预测的实用性仍然有限。
Abstract
This study aimed to assess the association between multiple atherogenic and insulin resistance indices-including TyG, TyG-BMI, AIP, TG-HDL, and METS-IR-and infertility in women with PCOS, and to evaluate their clinical utility. In this cross-sectional study, we analyzed data from 669 sexually active women aged 18-45 with PCOS treated at a tertiary center in Iran (2021-2023). We compared infertile women with PCOS (≥12 months unsuccessful conception, n = 274) to fertile women with PCOS (n = 395). Logistic regression, restricted cubic spline, and receiver operating characteristic (ROC) analysis were used to assess associations and predictive performance. Infertile women had significantly worse metabolic profiles across all indices (P < 0.001). AIP showed the largest point estimate of association (adjusted OR = 9.065, 95% CI: 1.722-47.721). TG-HDL showed a significant non-linear relationship, with ORs rising steeply up to a ratio of ~2.5. Predictive ability was modest, with AUCs ranging from 0.598 (TyG-BMI) to 0.625 (AIP, TG-HDL). Several metabolic indices, particularly AIP, are associated with infertility in women with PCOS, though their standalone predictive utility remains limited.
如何引用
AMA
Kasra Jafari, Nazanin Azmi-Naei, Nooshan Tajik, Ashraf Moini, Amene Abiri. Association between different atherogenic and insulin resistance indices and infertility in polycystic ovary syndrome patients.. PloS one. 2026; doi:10.1371/journal.pone.0343783.
APA
Kasra Jafari, Nazanin Azmi-Naei, Nooshan Tajik, Ashraf Moini, Amene Abiri (2026). Association between different atherogenic and insulin resistance indices and infertility in polycystic ovary syndrome patients.. PloS one. https://doi.org/10.1371/journal.pone.0343783
GB/T 7714
Kasra Jafari, Nazanin Azmi-Naei, Nooshan Tajik, Ashraf Moini, Amene Abiri. Association between different atherogenic and insulin resistance indices and infertility in polycystic ovary syndrome patients.[J]. PloS one, 2026 doi:10.1371/journal.pone.0343783.
在 PubMed增强版 阅读全文
翻译全文 · AI 文献问答 · PDF 原文下载 · 引用导出