基于美国食品药品监督管理局不良事件报告系统数据库的真实数据，对肺部手术后的药物进行探索性研究
Exploratory research on drugs after lung surgery based on real-world data from the FDA adverse event reporting system database.
摘要(中文译文)
肺手术是胸外科最常见的手术，但术后呼吸困难、咳嗽、心悸和胸痛严重影响患者的生活质量，并阻碍其术后康复。为揭示药物与不良事件之间的潜在相关性，我们采用不相称性分析，分别计算了报告病例数排名前30位的呼吸困难、咳嗽、心悸和胸痛相关药物的ROR值和PRR值。此外，我们通过生成韦恩图定义了肺术后高ROR信号药物和中ROR信号药物，并计算了所有用于治疗肺动脉高压的药物的PRR，以探讨肺动脉高压药物与这四种症状之间的相关性。我们确定了与呼吸困难、咳嗽、心悸和胸痛最相关的前30位药物，并定义了4种肺术后高ROR信号药物和10种肺术后中ROR信号药物。其中，3种高ROR信号药物为治疗肺动脉高压（PH）的药物。随后，进一步分析揭示，正是治疗PH这一基本药物属性容易导致肺术后这四种常见症状。我们的研究为肺手术术后患者提供了高ROR信号药物和中ROR信号药物清单，并阐明了治疗肺动脉高压药物的属性与呼吸困难、咳嗽、心悸和胸痛之间的潜在相关性，为术后患者的用药提供了理论依据。
Abstract
Lung surgery is the most common surgery in thoracic surgery, but postoperative dyspnea, cough, palpitations, and chest pain seriously affect the quality of life of patients and hinder their postoperative recovery. To reveal the potential correlation between drugs and adverse events, we used disproportionation analysis to calculate the ROR and PRR values of the top 30 reported cases of dyspnea, cough, palpitations, and chest pain, respectively. In addition, we defined high and medium ROR signaling drugs after lung surgery by generating Venn diagram and calculated the PRR of all drugs used to treat pulmonary hypertension to explore the correlation between pulmonary arterial hypertension drugs and these four symptoms. We identified the top 30 drugs that are most related to dyspnea, cough, palpitations, and chest pain, and defined 4 high ROR signaling drugs after lung surgery, and 10 medium ROR signaling drugs after lung surgery. Among them, 3 high ROR signaling drugs are drugs for treating pulmonary hypertension (PH). Subsequently, further analysis revealed that it is the basic drug attribute of treating PH that can easily cause these four common symptoms after lung surgery. Our study provides a list of high and medium ROR signaling drugs drugs for postoperative patients with lung surgery and clarifies the potential correlation between the properties of drugs for treating pulmonary arterial hypertension and dyspnea, cough, palpitations, and chest pain, providing a theoretical basis for the medication of postoperative patients.
如何引用
AMA
Qiaoling Pan, Hang Chen, Hanbo Pan, Zeyang Hu, Keyue Qiu, Jiaheng Zhang, et al. Exploratory research on drugs after lung surgery based on real-world data from the FDA adverse event reporting system database.. PloS one. 2026; doi:10.1371/journal.pone.0346792.
APA
Qiaoling Pan, Hang Chen, Hanbo Pan, Zeyang Hu, Keyue Qiu, Jiaheng Zhang, et al (2026). Exploratory research on drugs after lung surgery based on real-world data from the FDA adverse event reporting system database.. PloS one. https://doi.org/10.1371/journal.pone.0346792
GB/T 7714
Qiaoling Pan, Hang Chen, Hanbo Pan, Zeyang Hu, Keyue Qiu, Jiaheng Zhang, et al. Exploratory research on drugs after lung surgery based on real-world data from the FDA adverse event reporting system database.[J]. PloS one, 2026 doi:10.1371/journal.pone.0346792.
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