肝神经系统轴：通路、失调和翻译视角
Liver-nervous system axis: pathways, dysregulation, and translational perspectives.
摘要(中文译文)
肝脏与神经系统通过肝-神经轴形成动态的双向调控网络，对维持机体代谢稳态、免疫平衡及神经功能完整性至关重要。然而，肝脏与神经系统之间的具体调控通路及其在疾病发生发展中的机制尚未完全阐明，且血脑屏障在肝脏代谢物转运中的动态调控机制亦有待深入解析。为此，我们整合了近年来在肝脏神经支配、肝脏来源物质的神经调控效应以及炎症介质跨器官传导等领域的最新研究进展，并结合β受体阻滞剂、迷走神经刺激、肝移植等干预措施的临床转化证据，系统阐述了生理状态下肝脏与神经系统的协同调控规律，以及病理状态下二者交互紊乱的机制。旨在阐明肝脏与神经系统之间的相互作用及其在生理与病理过程中的意义，从而为未来相关研究提供理论依据和潜在治疗靶点。
Abstract
The liver and the nervous system form a dynamic bidirectional regulatory network through the liver-nervous system axis, which is crucial for maintaining metabolic homeostasis, immune balance, and the integrity of neural function in the body. However, the specific regulatory pathways between the liver and the nervous system, as well as their mechanisms in the development and progression of diseases, remain incompletely understood. Moreover, the dynamic regulatory mechanisms of the blood-brain barrier in the transport of liver metabolites are yet to be elucidated. Therefore, we have integrated the latest research advances in recent years in the fields of liver innervation, the neuroregulatory effects of liver-derived substances, and the trans-organ conduction of inflammatory mediators. Additionally, we incorporate clinical translational evidence from the application of β-blockers, vagus nerve stimulation, liver transplantation, and other interventions to systematically elucidate the coordinated regulatory patterns of the liver and the nervous system under physiological conditions, as well as the mechanisms of interactive disorders under pathological conditions. The aim is to clarify the interactions between the liver and the nervous system and their significance in physiological and pathological processes, thus providing a theoretical basis and potential therapeutic targets for future related research.
如何引用
AMA
Donglin Hao, Yuebo Hu, Wei Luo, Shihui Li, Yongmin Yan, Jing Zhou. Liver-nervous system axis: pathways, dysregulation, and translational perspectives.. Journal of neuroinflammation. 2026; doi:10.1186/s12974-026-03875-3.
APA
Donglin Hao, Yuebo Hu, Wei Luo, Shihui Li, Yongmin Yan, Jing Zhou (2026). Liver-nervous system axis: pathways, dysregulation, and translational perspectives.. Journal of neuroinflammation. https://doi.org/10.1186/s12974-026-03875-3
GB/T 7714
Donglin Hao, Yuebo Hu, Wei Luo, Shihui Li, Yongmin Yan, Jing Zhou. Liver-nervous system axis: pathways, dysregulation, and translational perspectives.[J]. Journal of neuroinflammation, 2026 doi:10.1186/s12974-026-03875-3.
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