SGLT2抑制剂治疗糖尿病肾病的文献计量学分析
Bibliometric analysis of SGLT2 inhibitor treatment for diabetic kidney disease.
摘要(中文译文)
钠-葡萄糖共转运蛋白2（SGLT2）抑制剂对糖尿病肾病展现出显著的肾脏保护潜力，而该领域的全面文献计量学分析尚属匮乏。本研究填补了这一空白，通过系统文献计量学分析，从Web of Science核心合集检索2013至2025年的相关文献，并运用CiteSpace和VOSviewer进行分析。共纳入2，415篇文献，年发文量呈指数增长。美国在发文量和被引频次方面均居首位；格罗宁根大学（167篇）为发文量最高的机构，已形成以核心学者为主导的成熟研究团队和合作网络。（163篇）为发文量最多的期刊。共被引分析识别出7个 distinct 聚类（自噬、酮症酸中毒、肾脏生长、非奈利酮、缺氧、肾小球滤过率、钠-葡萄糖共转运蛋白2）及两大核心方向：药物作用机制与临床治疗策略。突现关键词和关键词分析显示，研究焦点已从临床试验设计转向心肾保护机制，近期又转向精准疾病管理和联合治疗。未来研究应加强国际合作，探索SGLT2抑制剂与盐皮质激素受体拮抗剂的协同作用，并设计具有区域特异性终点的创新性临床试验。
Abstract
Sodium-glucose co-transporter 2 (SGLT2) inhibitors show significant renoprotective potential for diabetic kidney disease, while comprehensive bibliometric analyses in this field are scarce. This study addressed this gap a systematic bibliometric analysis, retrieving 2013-2025 relevant articles from the Web of Science Core Collection and analyzing them with CiteSpace and VOSviewer. A total of 2,415 articles were included, with annual publications growing exponentially. The United States led in publication volume and citations; the University of Groningen (167 papers) was the top institution, and a mature core-scholar-led research team and collaboration network has formed. (163 publications) was the most prolific journal. Co-citation analysis identified 7 distinct clusters (autophagy, ketoacidosis, renal growth, finerenone, hypoxia, glomerular filtration rate, sodium-glucose cotransporter 2) and two core directions: drug action mechanisms and clinical treatment strategies. Burst keyword and keyword analyses revealed the research focus shifted from clinical trial design to cardiorenal protective mechanisms, and recently to precision disease management and combination therapies. Future research should strengthen international collaboration, explore SGLT2 inhibitor-mineralocorticoid receptor antagonist synergies, and design innovative clinical trials with region-specific endpoints.
如何引用
AMA
Dan Hu, Liangmei Chen, Ruolan Mai, Tingmin Gao, Baozhang Guan. Bibliometric analysis of SGLT2 inhibitor treatment for diabetic kidney disease.. Renal failure. 2026; doi:10.1080/0886022X.2026.2667611.
APA
Dan Hu, Liangmei Chen, Ruolan Mai, Tingmin Gao, Baozhang Guan (2026). Bibliometric analysis of SGLT2 inhibitor treatment for diabetic kidney disease.. Renal failure. https://doi.org/10.1080/0886022X.2026.2667611
GB/T 7714
Dan Hu, Liangmei Chen, Ruolan Mai, Tingmin Gao, Baozhang Guan. Bibliometric analysis of SGLT2 inhibitor treatment for diabetic kidney disease.[J]. Renal failure, 2026 doi:10.1080/0886022X.2026.2667611.
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