HIF-1α/BNIP3通路调控线粒体自噬在肾小管间质纤维化中的机制及治疗前景
The mechanism and therapeutic prospect of HIF-1 α/BNIP3 pathway in regulating mitophagy in tubulointerstitial fibrosis.
摘要(中文译文)
肾小管间质纤维化(tubulointerstitial fibrosis，TIF)是终末期肾病(end-stage renal disease，ESRD)的关键病理标志和主要决定因素。TIF的机制尚不清楚，目前尚无特异性药物可延缓或逆转其进展。值得注意的是，由于肾脏独特的结构，肾功能障碍的病程与缺氧密切相关。缺氧诱导因子1α(hypoxia-inducible factor 1α，HIF-1α)及其下游靶基因B细胞淋巴瘤-2/腺病毒E1B 19-kDa相互作用蛋白(B-cell lymphoma-2/adenovirus E1B 19-kDa interacting protein，BNIP3)所形成的信号通路在肾脏缺氧过程中发挥关键作用。该通路介导线粒体自噬，抑制细胞凋亡和炎症反应，维持细胞能量平衡，从而深刻影响TIF的进展。本文聚焦于HIF-1α/BNIP3通路调控线粒体自噬并影响TIF的分子机制，并深入探讨其在细胞焦亡、氧化应激和缺血再灌注损伤中的作用机制，旨在为开发TIF新型治疗策略奠定理论基础并提供潜在干预靶点。
Abstract
Tubulointerstitial fibrosis (TIF) is a key pathological hallmark and a major determinant of end-stage renal disease (ESRD). The mechanisms of TIF remain unclear, and there are currently no specific drugs to slow or reverse its progression. Notably, due to the kidney's unique structure, the course of renal dysfunction is intimately connected with hypoxia. The signaling pathway formed by hypoxia-inducible factor 1α (HIF-1α) and its downstream target gene, B-cell lymphoma-2/adenovirus E1B 19-kDa interacting protein (BNIP3), exerts a pivotal effect during renal hypoxia. This pathway mediates mitophagy, inhibits apoptosis and inflammatory responses, maintains cellular energy balance, and thus profoundly influences the progression of TIF. This article focuses on the molecular mechanism by which the HIF-1α/BNIP3 pathway regulates mitophagy and affects TIF, and delves into its mechanisms in pyroptosis, oxidative stress, and ischemia-reperfusion injury, This work endeavors to establish a theoretical foundation and potential intervention targets for developing novel treatment strategies for TIF.
如何引用
AMA
Xinru Wang, Zhaoan Guo. The mechanism and therapeutic prospect of HIF-1 α/BNIP3 pathway in regulating mitophagy in tubulointerstitial fibrosis.. Renal failure. 2026; doi:10.1080/0886022X.2026.2667684.
APA
Xinru Wang, Zhaoan Guo (2026). The mechanism and therapeutic prospect of HIF-1 α/BNIP3 pathway in regulating mitophagy in tubulointerstitial fibrosis.. Renal failure. https://doi.org/10.1080/0886022X.2026.2667684
GB/T 7714
Xinru Wang, Zhaoan Guo. The mechanism and therapeutic prospect of HIF-1 α/BNIP3 pathway in regulating mitophagy in tubulointerstitial fibrosis.[J]. Renal failure, 2026 doi:10.1080/0886022X.2026.2667684.
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