杨梅素通过法尼醇X受体（FXR）抑制炎症反应和铁下垂，减轻小鼠肝脏缺血再灌注损伤
Myricetin alleviates hepatic ischemia-reperfusion injury in mice by inhibiting the inflammatory response and ferroptosis through farnesoid X receptor (FXR).
摘要(中文译文)
杨梅素是一种来源于杨梅果实的关键黄酮类单体，具有抗氧化和抗菌活性。然而，其在肝脏缺血再灌注损伤（HIRI）中的作用尚不清楚。在本研究中，我们发现杨梅素可抑制促炎细胞因子的表达，减少脂质过氧化和线粒体损伤从而抑制铁死亡，并减轻HIRI。RNA测序显示，杨梅素可能通过FXR信号通路调节炎症反应和铁死亡而发挥保护作用。分子对接显示杨梅素与FXR之间具有稳定的结合，且其可促进FXR的表达和激活。在FXR敲除小鼠中，FXR缺失减弱了杨梅素对HIRI小鼠肝脏炎症反应和铁死亡的抑制作用，并削弱了其对肝损伤的减轻效果。总之，这些发现确立了杨梅素作为一种通过激活FXR对抗HIRI的新型保护剂，为其在HIRI相关疾病中的潜在治疗应用提供了实验证据。
Abstract
Myricetin, a key flavonoid monomer derived from bayberry fruit, exhibits antioxidant and antibacterial activities. However, its role in hepatic ischemia-reperfusion injury (HIRI) is unclear. In the present study, we found that myricetin inhibited the expression of pro-inflammatory cytokines, reduced lipid peroxidation and mitochondrial damage to inhibit ferroptosis, and alleviated HIRI. RNA sequencing showed that myricetin may be protective by regulating inflammatory responses and ferroptosis through FXR signalling. Molecular docking showed a stable binding between myricetin and FXR, and it could promote the expression and activation of FXR. In FXR knockout mice, FXR deletion attenuated the inhibitory effect of myricetin on hepatic inflammatory response and ferroptosis in mice with HIRI, and weakened its mitigating effect on hepatic injury. Collectively, these findings establish myricetin as a novel protective agent against HIRI by activating the FXR, providing experimental evidence for its potential therapeutic application in HIRI-related diseases.
如何引用
AMA
Dandan Zhang, Leiming Yang, Shuang Guo, Yijun Pang, Weijia Zhang, Mi Chen, et al. Myricetin alleviates hepatic ischemia-reperfusion injury in mice by inhibiting the inflammatory response and ferroptosis through farnesoid X receptor (FXR).. International immunopharmacology. 2026; doi:10.1016/j.intimp.2026.116829.
APA
Dandan Zhang, Leiming Yang, Shuang Guo, Yijun Pang, Weijia Zhang, Mi Chen, et al (2026). Myricetin alleviates hepatic ischemia-reperfusion injury in mice by inhibiting the inflammatory response and ferroptosis through farnesoid X receptor (FXR).. International immunopharmacology. https://doi.org/10.1016/j.intimp.2026.116829
GB/T 7714
Dandan Zhang, Leiming Yang, Shuang Guo, Yijun Pang, Weijia Zhang, Mi Chen, et al. Myricetin alleviates hepatic ischemia-reperfusion injury in mice by inhibiting the inflammatory response and ferroptosis through farnesoid X receptor (FXR).[J]. International immunopharmacology, 2026 doi:10.1016/j.intimp.2026.116829.
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