泛光症在癌症中的作用：双剑效应和靶向治疗
Role of PANoptosis in cancer: Double-edged sword effects and targeted therapies.
摘要(中文译文)
PANoptosis是一种近年来被认识到的程序性细胞死亡的炎症形式，由称为PANoptosome的细胞质多蛋白复合物介导，该复合物整合了焦亡、凋亡和坏死性凋亡。在癌症中，PANoptosis表现出显著的双刃剑特性。一方面，其慢性或失调的激活可能通过维持炎症、塑造免疫抑制微环境以及促进侵袭和转移来推动肿瘤进展。另一方面，强烈诱导PANoptosis可通过触发免疫原性细胞死亡、克服凋亡抵抗以及使肿瘤对化疗、放疗和免疫治疗敏感来抑制肿瘤生长。重要的是，这些相反效应并非PANoptosis的固定属性，而是由信号强度、分子激活模式、肿瘤分期和肿瘤异质性共同决定。本综述总结了PANoptosis的分子机制及其在癌症中的双重作用，特别强调了靶向PANoptosis的治疗策略。同时也指出了主要的转化挑战，包括临床前证据占主导、缺乏可靠的生物标志物以及炎症相关毒性的风险，所有这些都凸显了在癌症治疗中对PANoptosis进行更精确和情境依赖性调控的必要性。
Abstract
PANoptosis is a recently recognized inflammatory form of programmed cell death mediated by the cytoplasmic multiprotein complex termed the PANoptosome, which integrates pyroptosis, apoptosis, and necroptosis. In cancer, PANoptosis exhibits a marked double-edged sword nature. On the one hand, its chronic or dysregulated activation may promote tumor progression by sustaining inflammation, shaping an immunosuppressive microenvironment, and facilitating invasion and metastasis. On the other hand, robust induction of PANoptosis can suppress tumor growth by triggering immunogenic cell death, overcoming apoptotic resistance, and sensitizing tumors to chemotherapy, radiotherapy, and immunotherapy. Importantly, these opposing effects are not fixed properties of PANoptosis, but are jointly determined by signal strength, molecular activation patterns, tumor stage, and tumor heterogeneity. This review summarizes the molecular mechanisms of PANoptosis and its dual roles in cancer, with particular emphasis on therapeutic strategies targeting PANoptosis. Major translational challenges are also highlighted, including the predominance of preclinical evidence, the lack of robust biomarkers, and the risk of inflammation-related toxicity, all of which underscore the need for more precise and context-dependent regulation of PANoptosis in cancer therapy.
如何引用
AMA
Bai-Yu Chen, Lu Li, Wen-Qing Wang, Yan Kong, Xi Wang, Meng-Yao Liu, et al. Role of PANoptosis in cancer: Double-edged sword effects and targeted therapies.. International immunopharmacology. 2026; doi:10.1016/j.intimp.2026.116702.
APA
Bai-Yu Chen, Lu Li, Wen-Qing Wang, Yan Kong, Xi Wang, Meng-Yao Liu, et al (2026). Role of PANoptosis in cancer: Double-edged sword effects and targeted therapies.. International immunopharmacology. https://doi.org/10.1016/j.intimp.2026.116702
GB/T 7714
Bai-Yu Chen, Lu Li, Wen-Qing Wang, Yan Kong, Xi Wang, Meng-Yao Liu, et al. Role of PANoptosis in cancer: Double-edged sword effects and targeted therapies.[J]. International immunopharmacology, 2026 doi:10.1016/j.intimp.2026.116702.
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