OSR2的泛癌分析，重点关注肺腺癌的潜在机制和治疗意义
Pan-cancer analysis of OSR2 with a focus on underlying mechanisms and therapeutic implications in lung adenocarcinoma.
摘要(中文译文)
转录因子Odd-skipped相关蛋白2（OSR2）参与多种生理过程，但其在癌症发病机制中的作用在很大程度上仍未明确。初步研究表明，OSR2可能促进多种实体瘤的侵袭和转移。然而，其在肿瘤微环境中的功能、预后价值以及预测不同癌种免疫治疗反应的潜力仍未被充分探索，值得进行全面系统的分析。我们利用TCGA和GEO的数据对OSR2进行了整合性泛癌分析。我们的分析系统评估了OSR2的表达模式、预后意义及其与肿瘤突变负荷（TMB）、微卫星不稳定性（MSI）、免疫浸润和免疫检查点基因表达的相关性。我们采用基因集富集分析对泛癌bulk RNA-seq和LUAD单细胞转录组数据进行了通路富集分析。OSR2在LUAD中的功能作用通过实验进一步验证。OSR2的表达在多种癌症中表现出显著的异质性，其表达水平升高与多种恶性肿瘤的不良预后相关。免疫浸润相关性分析和泛癌单细胞转录组分析揭示，OSR2表达与肿瘤微环境（TME）中的癌症相关成纤维细胞（CAFs）之间存在强关联。功能富集分析提示，OSR2可能通过诱导上皮-间质转化（EMT）促进肿瘤进展。此外，敲低OSR2可减弱CAFs的促肿瘤效应，从而抑制LUAD细胞的增殖和迁移。总之，我们的研究结果凸显了OSR2在肿瘤生物学和肿瘤微环境调控中的关键作用。OSR2有望成为人类癌症的预后生物标志物和潜在治疗靶点；此外，它可能作为LUAD免疫治疗反应的可靠预测指标。
Abstract
The transcription factor Odd-skipped related 2 (OSR2) is involved in multiple physiological processes, yet its role in cancer pathogenesis remains largely undefined. Preliminary studies have suggested that OSR2 may contribute to the invasion and metastasis of several solid tumors. However, its function in the tumor microenvironment, its prognostic value and potential in predicting responses to immunotherapy across different cancer types are still inadequately explored and warrant a comprehensive systematic analysis. We performed an integrated pan-cancer analysis of OSR2 utilizing data from TCGA and GEO. Our analysis systematically evaluated OSR2 expression patterns, prognostic significance, and its correlations with tumor mutational burden (TMB), microsatellite instability (MSI), immune infiltration and immune checkpoint gene expression. Gene set enrichment analysis was employed for pathway enrichment analysis in both the pan-cancer bulk RNA-seq and LUAD single-cell transcriptomic data. The functional roles of OSR2 in LUAD were further validated through experiments. OSR2 expression exhibited considerable heterogeneity across cancers, with elevated expression levels correlating with poor prognosis in several malignancies. Immune infiltration correlation and pan-cancer single-cell transcriptomics analysis revealed a strong association between OSR2 expression and cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TME). Functional enrichment analysis suggested that OSR2 may promote tumor progression through induction of epithelial-mesenchymal transition (EMT). Furthermore, OSR2 knockdown attenuated the tumor-promoting effects of CAFs, resulting in suppressed proliferation and migration of LUAD cells Collectively, our findings highlight the key role of OSR2 in tumor biology and tumor microenvironment regulation. OSR2 emerges as a promising prognostic biomarker and potential therapeutic target for human cancers; additionally, it may act as a reliable predictor of immunotherapy response in LUAD.
如何引用
AMA
Shijie Liu, Xuan Xiang, Siyu Liu, Wenbei Peng, Zihao Wang, Linlin Ye, et al. Pan-cancer analysis of OSR2 with a focus on underlying mechanisms and therapeutic implications in lung adenocarcinoma.. Frontiers in immunology. 2026; doi:10.3389/fimmu.2026.1769446.
APA
Shijie Liu, Xuan Xiang, Siyu Liu, Wenbei Peng, Zihao Wang, Linlin Ye, et al (2026). Pan-cancer analysis of OSR2 with a focus on underlying mechanisms and therapeutic implications in lung adenocarcinoma.. Frontiers in immunology. https://doi.org/10.3389/fimmu.2026.1769446
GB/T 7714
Shijie Liu, Xuan Xiang, Siyu Liu, Wenbei Peng, Zihao Wang, Linlin Ye, et al. Pan-cancer analysis of OSR2 with a focus on underlying mechanisms and therapeutic implications in lung adenocarcinoma.[J]. Frontiers in immunology, 2026 doi:10.3389/fimmu.2026.1769446.
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