与间质性膀胱炎相关的信号通路
Signaling pathways related to interstitial cystitis.
摘要(中文译文)
间质性膀胱炎/膀胱疼痛综合征(IC/BPS)是一种慢性、非感染性膀胱炎症性疾病,主要影响女性。主要症状包括持续性盆腔疼痛、尿频和尿急,常伴有功能性躯体疼痛综合征和心理健康障碍。IC症状的严重程度显著损害患者的生活质量,凸显了对IC/BPS发病机制、进展及治疗进行研究的必要性。尽管IC的确切病因尚不明确,且尚无简单或明确的诊断方法,但目前临床治疗主要侧重于缓解症状而非治愈。近年来,针对IC病因学和病理生理学的大量实验研究已鉴定出众多参与疾病启动、进展及自我修复机制的信号通路。本研究聚焦于IC相关信号通路,分析关键分子信号在IC发生和进展中的作用。通过将临床症状和体征与分子生物学见解相结合,我们对IC的病因学和病理生理学活动进行了全面综述和比较分析。旨在为开发更高效的IC诊断工具、药物疗法、治疗评估及预防策略奠定理论基础。
Abstract
Interstitial cystitis/bladder pain syndrome (IC/BPS) represents a chronic, non-infectious inflammatory bladder disorder, predominantly affecting women. Primary symptoms include ongoing pelvic pain, frequent urination, and urgency, often accompanied by functional somatic pain syndromes and psychological health disturbances. The severity of IC symptoms significantly impairs patients' quality of life, highlighting the necessity for research on the pathogenesis, progression, and treatment of IC/BPS. Although the exact etiology of IC remains unclear, and there is no simple or definitive diagnostic method, current clinical treatments primarily focus on symptom relief rather than a cure. In recent years, extensive experimental studies on the etiology and pathophysiology of IC have identified a multitude of signaling pathways involved in the disease's initiation, progression, and self-repair mechanisms. This study focuses on IC-related signaling pathways, analyzing the role of key molecular signals in the onset and progression of IC. By integrating clinical symptoms and signs with molecular biology insights, we provide a comprehensive overview and comparative analysis of IC's etiology and pathophysiological activities. The goal is to establish a theoretical foundation for the development of more efficient diagnostic tools, drug therapies, treatment evaluations, and preventive strategies for IC.
如何引用
AMA
Haowen Wang, Shuang Liu, Yuan Sun, Lina Wang. Signaling pathways related to interstitial cystitis.. Frontiers in immunology. 2026; doi:10.3389/fimmu.2026.1774072.
APA
Haowen Wang, Shuang Liu, Yuan Sun, Lina Wang (2026). Signaling pathways related to interstitial cystitis.. Frontiers in immunology. https://doi.org/10.3389/fimmu.2026.1774072
GB/T 7714
Haowen Wang, Shuang Liu, Yuan Sun, Lina Wang. Signaling pathways related to interstitial cystitis.[J]. Frontiers in immunology, 2026 doi:10.3389/fimmu.2026.1774072.
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