特发性肺纤维化定量肺超声参数与肺功能的相关性分析：一项观察性研究
Correlation analysis between quantitative lung ultrasound parameters and pulmonary function in idiopathic pulmonary fibrosis: an observational study.
摘要(中文译文)
特发性肺纤维化（IPF）是一种进行性且致命的间质性肺病（ILD），监测手段有限。肺超声（LUS）作为一种有前景的无辐射替代方法已经出现，但其在IPF中的临床实用性仍需进一步验证。本研究旨在全面评估IPF患者定量LUS参数与已确定的疾病严重程度标志物之间的相关性。在符合条件的IPF患者中开展了一项观察性研究。参与者接受了综合评估，包括临床问卷、肺功能检查、血清KL-6测定、高分辨率计算机断层扫描（HRCT）以及标准化LUS方案。采用相关性和多元线性回归分析来检验LUS指标与常规严重程度标志物之间的关系。分析纳入47例IPF患者，按DLCO占预计值百分比分层（≥60%为轻度，<60%为中重度）。中重度组的B线计数、B线评分、胸膜评分、膈肌厚度显著更高，而膈肌增厚分数更低（0.05）。B线计数、B线评分、胸膜评分和膈肌厚度均与DLCO占预计值百分比呈显著负相关（分别为r = -0.84，0.01；r = -0.87，0.01；r = -0.80，0.01；r = -0.58，0.05）。相反，膈肌增厚分数与DLCO占预计值百分比呈显著正相关（r = 0.44，0.05）。多变量回归分析确定DLCO占预计值百分比是B线计数（= -0.604，0.001）、B线评分（= -0.846，0.001）和胸膜评分（= -0.860，0.001）的显著负向指标。SGRQ评分与B线计数（= 0.308，= 0.019）和B线评分（= 0.336，= 0.012）均呈正相关。Warrick评分与B线计数呈正相关（= 0.240，= 0.015），但与胸膜评分呈负相关（= -0.295，= 0.011）。BMI也与胸膜评分呈负相关（= -0.233，= 0.016）。定量LUS参数与IPF严重程度的临床、功能、血清学和影像学标志物显示出强且一致的相关性。这些发现支持LUS作为IPF患者多维疾病评估的综合性、无创性工具的潜在用途。
Abstract
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease (ILD) with limited monitoring tools. Lung ultrasound (LUS) has emerged as a promising radiation-free alternative, but its clinical utility in IPF requires further validation. This study aimed to comprehensively evaluate the correlation between quantitative LUS parameters and established disease severity markers in IPF patients. An observational study was conducted in eligible IPF patients. Participants underwent comprehensive assessment including clinical questionnaires, pulmonary function tests, serum KL-6 measurement, high-resolution computed tomography (HRCT), and a standardized LUS protocol. Correlation and multiple linear regression analyses were performed to examine the relationships between LUS indices and conventional severity markers. The analysis included 47 IPF patients stratified by DLCO% predicted (≥60% mild, <60% moderate-severe). The moderate-severe group showed significantly higher B-line counts, B-line scores, pleural scores, diaphragm thickness and lower diaphragm thickening fraction ( 0.05). B-line count, B-line score, pleural score, and diaphragmatic thickness all exhibited significant negative correlations with DLCO% predicted (r = -0.84, 0.01; r = -0.87, 0.01; r = -0.80, 0.01; and r = -0.58, 0.05, respectively). Conversely, the diaphragmatic thickening fraction showed a significant positive correlation with DLCO% predicted (r = 0.44, 0.05). Multivariable regression analyses identified DLCO% predicted as a significant negative indicator of B-line count ( = -0.604, 0.001), B-line score ( = -0.846, 0.001), and pleural score ( = -0.860, 0.001). SGRQ score was positively associated with both B-line count ( = 0.308, = 0.019) and B-line score ( = 0.336, = 0.012). Warrick score exhibited a positive association with B-line count ( = 0.240, = 0.015) but a negative association with pleural score ( = -0.295, = 0.011). BMI also showed a negative association with pleural score ( = -0.233, = 0.016). Quantitative LUS parameters show strong and consistent correlations with clinical, functional, serological, and radiographic markers of IPF severity. These findings support the potential utility of LUS as a comprehensive, non-invasive tool for multidimensional disease assessment in IPF patients.
如何引用
AMA
Ting Zhou, Xing He, Xueming Ju, Chun Zhang, Hui Fang, Yang Liu, et al. Correlation analysis between quantitative lung ultrasound parameters and pulmonary function in idiopathic pulmonary fibrosis: an observational study.. Frontiers in medicine. 2026; doi:10.3389/fmed.2026.1821397.
APA
Ting Zhou, Xing He, Xueming Ju, Chun Zhang, Hui Fang, Yang Liu, et al (2026). Correlation analysis between quantitative lung ultrasound parameters and pulmonary function in idiopathic pulmonary fibrosis: an observational study.. Frontiers in medicine. https://doi.org/10.3389/fmed.2026.1821397
GB/T 7714
Ting Zhou, Xing He, Xueming Ju, Chun Zhang, Hui Fang, Yang Liu, et al. Correlation analysis between quantitative lung ultrasound parameters and pulmonary function in idiopathic pulmonary fibrosis: an observational study.[J]. Frontiers in medicine, 2026 doi:10.3389/fmed.2026.1821397.
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