妊娠早期（<20周）甘油三酯-葡萄糖指数与妊娠并发症及不良妊娠结局的相关性：一项系统综述和荟萃分析
The correlation between triglyceride-glucose index in early pregnancy (<20 weeks) and pregnancy complications and adverse pregnancy outcomes: a systematic review and meta-analysis.
摘要(中文译文)
早孕期胰岛素抵抗可独立导致妊娠期糖尿病及不良妊娠结局的发生。采用meta分析方法评估早孕期甘油三酯-葡萄糖（TyG）指数与妊娠并发症及不良妊娠结局之间的关系。检索中国知网、万方数据库、维普数据库、中国生物医学文献数据库、PubMed、Embase、Web of Science及Cochrane Library。检索时间范围为各数据库建库至2025年12月28日。由两名研究者采用纽卡斯尔-渥太华量表评估纳入研究的质量并提取数据。采用RevMan 5.4和Stata 17.0进行统计分析。共纳入23项研究，涉及220 985名参与者，其中暴露个体61 774名。Meta分析显示，与早孕期低TyG指数相比，高TyG指数与妊娠期糖尿病、妊娠期高血压、子痫前期、早产、大于胎龄儿及巨大儿的发生风险增加显著相关（P<0.05）。早孕期高TyG指数与妊娠期糖尿病、妊娠期高血压、子痫前期、早产、大于胎龄儿及巨大儿的发生呈显著正相关。TyG指数可作为孕妇高危妊娠早期诊断的简便可靠指标，有助于医疗保健人员及时进行临床干预，以降低妊娠并发症及不良妊娠结局的发生率。https://www.crd.york.ac.uk/PROSPERO/view/CRD420261293271，注册号CRD420261293271。
Abstract
Insulin resistance in the early pregnancy stage can independently lead to the occurrence of gestational diabetes mellitus and adverse pregnancy outcomes. To evaluate the relationship between the Triglyceride-Glucose (TyG) index in early pregnancy and pregnancy complications and adverse pregnancy outcomes using meta-analysis. Search the CNKI, Wanfang, VIP, China Biomedical Literature database, PubMed, Embase, Web of Science, and the Cochrane Library. The search covered the period from the establishment of each database to December 28, 2025. Two researchers using the Newcastle-Ottawa Scale to assess the quality of the included studies and extracted data. Statistical analysis was performed using RevMan 5.4 and Stata 17.0. Twenty-three studies were included, involving 220,985 participants with 61,774 exposed individuals. Meta-analysis revealed that compared with low TyG index in early pregnancy, high TyG index was significantly associated with increased risks of gestational diabetes mellitus, gestational hypertension, preeclampsia, preterm birth, large for gestational age, and macrosomia ( < 0.05). A high TyG index in early pregnancy is significantly positively associated with the occurrence of gestational diabetes, gestational hypertension, preeclampsia, preterm birth, large for gestational age, and macrosomia. The TyG index can serve as a simple and reliable indicator for the early diagnosis of high-risk pregnancies in pregnant women, facilitating timely clinical intervention by healthcare providers to reduce the incidence of pregnancy complications and adverse pregnancy outcomes. https://www.crd.york.ac.uk/PROSPERO/view/CRD420261293271, Identifier CRD420261293271.
如何引用
AMA
Wenli Zhang, Junzhi Wang, Liangliang Chu, Xinyu Pi, Guochun Zhang. The correlation between triglyceride-glucose index in early pregnancy (<20 weeks) and pregnancy complications and adverse pregnancy outcomes: a systematic review and meta-analysis.. Frontiers in medicine. 2026; doi:10.3389/fmed.2026.1811358.
APA
Wenli Zhang, Junzhi Wang, Liangliang Chu, Xinyu Pi, Guochun Zhang (2026). The correlation between triglyceride-glucose index in early pregnancy (<20 weeks) and pregnancy complications and adverse pregnancy outcomes: a systematic review and meta-analysis.. Frontiers in medicine. https://doi.org/10.3389/fmed.2026.1811358
GB/T 7714
Wenli Zhang, Junzhi Wang, Liangliang Chu, Xinyu Pi, Guochun Zhang. The correlation between triglyceride-glucose index in early pregnancy (<20 weeks) and pregnancy complications and adverse pregnancy outcomes: a systematic review and meta-analysis.[J]. Frontiers in medicine, 2026 doi:10.3389/fmed.2026.1811358.
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