LOX-A4塑造了乌拉尔图小麦基因库并贡献于多倍体小麦A亚基因组
LOX-A4 shapes Triticum urartu gene pools and contributions to the A subgenome of polyploid wheat.
摘要(中文译文)
脂氧合酶（LOXs）在植物生长和防御中发挥着重要作用。本研究通过基因组学和分子分析，发现了一个主要的LOX基因（LOX-A4），其在乌拉尔图小麦（Triticum urartu，Tu）中差异表达，乌拉尔图小麦是多倍体小麦A亚基因组的二倍体祖先。与携带野生型基因（LOX-A4）的Tu种质相比，携带突变等位基因（LOX-A4）的种质表现出更好的生长但较低的胁迫耐受性。这些差异与LOX-A4种质在新月沃地的地理分布比LOX-A4材料更广泛相一致。有趣的是，在全球3，516份四倍体和六倍体小麦品系中仅检测到突变型LOX-A4等位基因；在普通小麦中恢复LOX-A4表达会抑制生长但增强胁迫耐受性。此外，全基因组同态一致性分析揭示，多倍体小麦A亚基因组与13份LOX-A4 Tu种质中的A基因组关系更为密切。因此，我们的工作提供了证据，表明LOX基因变异通过调控生长-防御权衡塑造了植物基因库及其对多倍体基因组形成的贡献。
Abstract
Lipoxygenases (LOXs) play vital roles in plant growth and defense. In this study, through genomic and molecular analyses, we discover a major LOX gene (LOX-A4) differentially expressed in Triticum urartu (Tu), the diploid progenitor of A subgenome in polyploid wheat. Compared to Tu accessions carrying wild type gene (LOX-A4), those bearing mutant allele (LOX-A4) show better growth but lower stress tolerance. These differences concur with a wider geographical distribution of LOX-A4 accessions than LOX-A4 materials in the Fertile Crescent. Interestingly, only mutant LOX-A4 alleles are detected in 3,516 worldwide tetraploid and hexaploid wheat lines; restoring LOX-A4 expression in common wheat inhibits growth but enhances stress tolerance. Furthermore, genome-wide identity-by-state analysis reveals that polyploid wheat A subgenome is more related to the A genome in 13 LOX-A4 Tu accessions. Thus, our work provides evidence that LOX gene variation shapes plant gene pools and their contributions to polyploid genome formation via regulating growth-defense trade-offs.
如何引用
AMA
Bei Li, Zhiyong Wang, Lingli Dong, Zhenying Dong, Kunpu Zhang, Yanpeng Wang, et al. LOX-A4 shapes Triticum urartu gene pools and contributions to the A subgenome of polyploid wheat.. Nature communications. 2026; doi:10.1038/s41467-026-71539-0.
APA
Bei Li, Zhiyong Wang, Lingli Dong, Zhenying Dong, Kunpu Zhang, Yanpeng Wang, et al (2026). LOX-A4 shapes Triticum urartu gene pools and contributions to the A subgenome of polyploid wheat.. Nature communications. https://doi.org/10.1038/s41467-026-71539-0
GB/T 7714
Bei Li, Zhiyong Wang, Lingli Dong, Zhenying Dong, Kunpu Zhang, Yanpeng Wang, et al. LOX-A4 shapes Triticum urartu gene pools and contributions to the A subgenome of polyploid wheat.[J]. Nature communications, 2026 doi:10.1038/s41467-026-71539-0.
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