LPs-1a：一种来自柠檬皮的降血糖果胶多糖——分离、结构表征和活性评估
LPs-1a: A hypoglycemic pectic polysaccharide from lemon peel - isolation, structural characterization, and activity evaluation.
摘要(中文译文)
为应对全球对可持续、天然功能性食品成分用于2型糖尿病（T2DM）管理的迫切需求，本研究系统探讨了从工业柠檬皮废弃物中纯化得到的一种新型果胶多糖（LPs-1a）的降血糖潜力及其潜在机制。通过全面的结构表征，LPs-1a被鉴定为一种低甲氧基、富含RG-I的果胶类群，具有中等分子量（195.26 kDa）和分支结构，其特征为关键的1→3、1→4和1→5糖苷键连接，符合生物活性多糖的特征。在高糖诱导的Min6胰腺β细胞损伤模型中，200 μg/mL的LPs-1a显著增强了葡萄糖摄取和胰岛素分泌。进一步的代谢组学分析表明，LPs-1a发挥多通路调控作用，其中组氨酸代谢在其细胞修复功能中起核心作用。这些发现不仅阐明了柠檬皮来源多糖的特定构效关系，还凸显了LPs-1a作为一种有科学依据的天然候选物，可用于开发旨在支持血糖控制的功能性食品、膳食补充剂或营养保健品。本研究为农业副产物的高值化利用提供了有价值的策略，有助于健康创新和可持续资源管理。
Abstract
In response to the urgent global need for sustainable, natural functional food ingredients for type 2 diabetes (T2DM) management, this study systematically investigates the hypoglycemic potential and underlying mechanisms of a novel pectic polysaccharide (LPs-1a) purified from industrial lemon peel waste. Through comprehensive structural characterization, LPs-1a was identified as a low-methoxyl RG-I-rich pectin groups with a moderate molecular weight (195.26 kDa) and a branched architecture featuring key 1 → 3, 1 → 4, and 1 → 5 glycosidic linkages, consistent with bioactive polysaccharide features. In a high-glucose-induced Min6 pancreatic β-cell injury model, LPs-1a at 200 μg/mL significantly enhanced glucose uptake and insulin secretion. Further metabolomic analysis demonstrated that LPs-1a exerts multi-pathway regulatory effects, with histidine metabolism playing a central role in its cellular repair function. These findings not only elucidate the specific structure-activity relationship of lemon peel-derived polysaccharides but also highlight LPs-1a as a scientifically grounded, natural candidate for the development of functional foods, dietary supplements, or nutraceuticals aimed at supporting glycemic control. This work provides a valuable strategy for the high-value utilization of agricultural by-products, contributing to both health innovation and sustainable resource management.
如何引用
AMA
Meng Xi, Yakun Hou, Zhonggui Jiang, Di Li, Pan He, Jie Yan, et al. LPs-1a: A hypoglycemic pectic polysaccharide from lemon peel - isolation, structural characterization, and activity evaluation.. International journal of biological macromolecules. 2026; doi:10.1016/j.ijbiomac.2026.152020.
APA
Meng Xi, Yakun Hou, Zhonggui Jiang, Di Li, Pan He, Jie Yan, et al (2026). LPs-1a: A hypoglycemic pectic polysaccharide from lemon peel - isolation, structural characterization, and activity evaluation.. International journal of biological macromolecules. https://doi.org/10.1016/j.ijbiomac.2026.152020
GB/T 7714
Meng Xi, Yakun Hou, Zhonggui Jiang, Di Li, Pan He, Jie Yan, et al. LPs-1a: A hypoglycemic pectic polysaccharide from lemon peel - isolation, structural characterization, and activity evaluation.[J]. International journal of biological macromolecules, 2026 doi:10.1016/j.ijbiomac.2026.152020.
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