通过体外、平面生物测定和高分辨率质谱法对来自食品接触材料的危险移民进行检测
Hazardous migrants from food contact materials by in vitro as well as planar bioassays and high-resolution mass spectrometry.
摘要(中文译文)
食品接触材料可能含有数千种化学物质，这些物质可迁移进入食品并被消费者吸收。当前的靶向分析忽视了缺乏任何毒理学数据的未知有害物质。因此，研究人员开发了非靶向效应导向策略，并将其应用于六种迁移物，以评估其对人类健康的潜在不良影响。采用体外和平面生物测定法，对四个外带咖啡杯和两个外带餐盒中的内分泌活性、细胞毒性、遗传毒性和二噁英类迁移物进行了分析。细胞毒性、遗传毒性和内分泌活性物质从聚乙烯涂层纤维素基外带咖啡杯中迁移而出，此外，二噁英类、遗传毒性和雌激素活性物质也从纤维素基外带餐盒中迁移而出。通过S9肝酶系统，观察到代谢活化和代谢失活两种现象。高效薄层色谱联用高分辨质谱，随后对候选物进行联合分析，确定了五个优先化合物区带，分别为雌激素活性的2,5-二羟基环己-2,5-二烯-1,4-二酮、4-辛基酚和邻苯二甲酸二丁酯，细胞毒性的（羟乙基）甲基丙烯酸酯，以及遗传毒性的1,6-己二醇二甲基丙烯酸酯。检测到的两种全氟调聚物关注度较低。
Abstract
Food contact materials may contain thousands of chemicals that can migrate into food and be absorbed by consumers. Current target analysis overlooks unknown hazardous substances without any toxicological data. Thus, non-target effect-directed strategies were developed and applied to six migrates for potentially adverse effects on human health. Four coffee-to-go cups and two meal-to-go boxes were analyzed for endocrine-active, cytotoxic, genotoxic, and dioxin-like migrants by in vitro and planar bioassays. Cytotoxic, genotoxic and endocrine-active substances migrated from the polyethylene-coated cellulose-based coffee-to-go cups, and additionally, dioxin-like, genotoxic and estrogenic substances from the cellulose-based meal-to-go boxes. Via the S9 liver enzyme system, both metabolic activation and deactivation were observed. High-performance thin-layer chromatography coupled with high-resolution mass spectrometry, followed by co-analysis of candidates, identified five prioritized compound zones to be the estrogenic 2,5-dihydroxycyclohexa-2,5-diene-1,4-dione, 4-octylphenol, and dibutyl phthalate, cytotoxic (hydroxyethyl) methacrylate, and genotoxic 1,6-hexanediol dimethacrylate. Two detected perfluorotelomers were of low concern.
如何引用
AMA
Anne E Ringelmann, Lina König, Andrea Dombrowski, Jörg Oehlmann, Sarah Johann, Jakob Pfefferle, et al. Hazardous migrants from food contact materials by in vitro as well as planar bioassays and high-resolution mass spectrometry.. Food chemistry. 2026; doi:10.1016/j.foodchem.2026.148659.
APA
Anne E Ringelmann, Lina König, Andrea Dombrowski, Jörg Oehlmann, Sarah Johann, Jakob Pfefferle, et al (2026). Hazardous migrants from food contact materials by in vitro as well as planar bioassays and high-resolution mass spectrometry.. Food chemistry. https://doi.org/10.1016/j.foodchem.2026.148659
GB/T 7714
Anne E Ringelmann, Lina König, Andrea Dombrowski, Jörg Oehlmann, Sarah Johann, Jakob Pfefferle, et al. Hazardous migrants from food contact materials by in vitro as well as planar bioassays and high-resolution mass spectrometry.[J]. Food chemistry, 2026 doi:10.1016/j.foodchem.2026.148659.
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